Protein Alignment Sec24AB and SEC24A

DIOPT Version :10

• Sequence 1: NP_610531.1
• Gene: Sec24AB / 36025
• FlyBaseID: FBgn0033460
• Length: 1184
• Species: Drosophila melanogaster
• Sequence 2: NP_068817.1
• Gene: SEC24A / 10802
• HGNCID: 10703
• Length: 1093
• Species: Homo sapiens
• Alignment Length: 1200
• Identity: 502/1200 - (41%)
• Similarity: 680/1200 - (56%)
• Gaps: 190/1200 - (15%)

  Fly    62 PGAGAPGNVPPPQQFNSGIT-NQFLPPTSGAATPLQ----------------QLPPSTLPPHLRP 109
            ||..|.|..|...|..:|.. ....|.|:|   |:|                |||.|.  ||  |
Human     4 PGIPASGGAPASLQAQNGAALASGSPYTNG---PVQNALLSSQESVSQGYNFQLPGSY--PH--P 61

  Fly   110 -PAANGPPLTNGSNGASSANSSRTASPRPVGAAPQYAQGPIAAALNNPPLASGLRP-SPQPTHQS 172
             ||....|::..||...|..|.:|.:..||      |..|:     .|.|.||..| .|.|..|:
Human    62 IPAKTLNPVSGQSNYGGSQGSGQTLNRPPV------ASNPV-----TPSLHSGPAPRMPLPASQN 115

  Fly   173 LANL----TSNLENLNLNTTRANGGTSILPQP-QTQQQYAPTVTQKDGRGVASAQTGPPQFNDAN 232
            .|..    :|.|...|            ||.| ..|..|..|.:|.:....||:|
Human   116 PATTPMPSSSFLPEAN------------LPPPLNWQYNYPSTASQTNHCPRASSQ---------- 158

  Fly   233 SLLAASGVAAALVPNAMATPFSGQKPPNLAPNPAKMFGSASMAGRPTPAGQRIPYGVPPPTNPEQ 297
                                      |.::       |:.|:    |...|.:..|.|
Human   159 --------------------------PTVS-------GNTSL----TTNHQYVSSGYP------- 179

  Fly   298 QSQQNNNLQNAPP-PPRVGAVWPPSLPNVAAPGAQPMMPPA-------QQTPQTYPYSQVYQP-- 352
             |.||:.:::.|. ||.|.    |.||....|||....|||       ..||.|..|..|.||
Human   180 -SLQNSFIKSGPSVPPLVN----PPLPTTFQPGAPHGPPPAGGPPPVRALTPLTSSYRDVPQPLF 239

  Fly   353 ----------------------------------GPQ---QQPPPPQS---AVQPPPPGMFGTQP 377
                                              .||   :.|...:|   :....|||...|.|
Human   240 NSAVNQEGITSNTNNGSMVVHSSYDEIEGGGLLATPQLTNKNPKMSRSVGYSYPSLPPGYQNTTP 304

  Fly   378 TGAPLQYQAQAPPQA--YGQHPQQAPQTAPGGPYGTTAPLNVAQQGFSRLWGQDTIDLMQNRHIL 440
            .||     ...||.:  |...||...||..|..:.||:...::.|.    .|...::|:|.|::|
Human   305 PGA-----TGVPPSSLNYPSGPQAFTQTPLGANHLTTSMSGLSLQP----EGLRVVNLLQERNML 360

  Fly   441 TPATLPPPKVVLHNQFHESINCSPSIMRCTLTKIPESNSLLQKSRLPLGIVIHPFRDVNSLPVIQ 505
            ....|.||...||... :.:||:|.:.|||||.||::.:||.|::||||:::|||:|:..|||:.
Human   361 PSTPLKPPVPNLHEDI-QKLNCNPELFRCTLTSIPQTQALLNKAKLPLGLLLHPFKDLVQLPVVT 424

  Fly   506 CINIVRCRLCRTYINPFVYFVDSKMWKCNLCYRVNELPDDFQFDPATKTYGDVTRRPEVRSSTIE 570
            ...|||||.|||||||||.|:|.:.||||||||||::|::|.::|.|:.||:..|||||:::|||
Human   425 SSTIVRCRSCRTYINPFVSFLDQRRWKCNLCYRVNDVPEEFLYNPLTRVYGEPHRRPEVQNATIE 489

  Fly   571 FIAPSEYMLRPPQPAMYLFLFDVSIIAQQSGYLEAACAVLNRHLDEMPGDARTQVGFICFDSFVH 635
            |:||||||||||||.:|||:||||..|.::|||.:.|..|..:||.:||:.||::|||.|||.:|
Human   490 FMAPSEYMLRPPQPPVYLFVFDVSHNAVETGYLNSVCQSLLDNLDLLPGNTRTKIGFITFDSTIH 554

  Fly   636 FYSMAEGLNQPHEMTLLDIEDPFLPRPDSLLVNLKECKELVRDLLKQLPKRFAHTHDPGSALGAA 700
            ||.:.|.|:||..:.:.||||.|:|.|::|||||.|.||||:||||.||:.|..|.:..||||.|
Human   555 FYGLQESLSQPQMLIVSDIEDVFIPMPENLLVNLNESKELVQDLLKTLPQMFTKTLETQSALGPA 619

  Fly   701 LQVAFKLMQASGGRITVFQSCLPNKGPGALEPREDPNNR-SAKDVAHLNPATDFYKRFALECSGY 764
            ||.|||||..:|||::|||:.||..|.|||:|||:||:| ||||: |:.|:|||||:.||:|||.
Human   620 LQAAFKLMSPTGGRMSVFQTQLPTLGVGALKPREEPNHRSSAKDI-HMTPSTDFYKKLALDCSGQ 683

  Fly   765 QIACDLFLMNQQYSDMATISGISKHSGGCVHHFPLY-QKTKPHMVESFRSCFKRYLTRKIGFEAV 828
            |:|.||||::.||||:|::..||::|.|.|:::|.| .:..|..|:..:...:||||||||||||
Human   684 QVAVDLFLLSGQYSDLASLGCISRYSAGSVYYYPSYHHQHNPVQVQKLQKELQRYLTRKIGFEAV 748

  Fly   829 MRIRCTRGLQVHTFHGNFFVRSTDLLSLPNVNPDAGYGMQISYEESLTDAKTICFQAALLYTNSE 893
            ||||||:||.:||||||||||||||||||||||||||.:|:|.||||||.:.:.||:|||||:|:
Human   749 MRIRCTKGLSIHTFHGNFFVRSTDLLSLPNVNPDAGYAVQMSVEESLTDTQLVSFQSALLYTSSK 813

  Fly   894 GERRIRVHTVCLPVTASLPEVMHSADTEAIIGLLSKMAVDRSVASNLSDARDAFINATIDVYNAF 958
            |||||||||:||||.::|.:|...||.:||.|||:.||||||:.::|||||||.:||.||..:|:
Human   814 GERRIRVHTLCLPVVSTLNDVFLGADVQAISGLLANMAVDRSMTASLSDARDALVNAVIDSLSAY 878

  Fly   959 KIAQNLPSGQSGQLIAPRSLALLPLYILALLKHPAFRVGTSTRLDDRVYAMDCMKTLPLDQLMKY 1023
            :  .::.|.|...|:.|.||.|.||::|||||..:|:.||:.|||:|::||..:|..||..||..
Human   879 R--SSVLSNQQPGLMVPFSLRLFPLFVLALLKQKSFQTGTNARLDERIFAMCQVKNQPLVYLMLT 941

  Fly  1024 VYPELYKIDALIYHARNSNISSNQDDDEDEDEPLPELPRLQLSAEHLDSRSIFLMDCGTLIMIYV 1088
            .:|.||::|.|          |::......|..:|:.|.||||.|.|.....||||.|:::|::|
Human   942 THPSLYRVDNL----------SDEGALNISDRTIPQPPILQLSVEKLSRDGAFLMDAGSVLMLWV 996

  Fly  1089 GLNVPPDVLEAVLGISSTAELGDYVYGLPNVVSNENDVLKRFILRLNYDKPYSALVQIIRDTSTA 1153
            |.|...:.|..|||:.:.|.:...:..||.:.:.|:..:..||..|...:|:..::.:|||.|..
Human   997 GKNCTQNFLSQVLGVQNYASIPQPMTDLPELDTPESARIIAFISWLREQRPFFPILYVIRDESPM 1061

  Fly  1154 KGQFTERLTDDRSESSLSYYEFLQHIRAQV 1183
            |..|.:.:.:||:||:|||||||.||:.||
Human  1062 KANFLQNMIEDRTESALSYYEFLLHIQQQV 1091

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec24AB	NP_610531.1	PHA03247	<72..426	CDD:223021	100/429 (23%)
		COG5028	383..1184	CDD:227361	407/804 (51%)
SEC24A	NP_068817.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29		7/24 (29%)
		Atrophin-1	<55..>159	CDD:460830	39/166 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	60..168		39/179 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	189..226		13/40 (33%)
		COG5028	237..1093	CDD:227361	419/877 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	294..328		13/38 (34%)
		Zinc finger-like	431..455		17/23 (74%)
		Gelsolin-like. /evidence=ECO:0000255	966..1038		25/71 (35%)