Protein Alignment Sec24AB and SEC24B

DIOPT Version :10

• Sequence 1: NP_610531.1
• Gene: Sec24AB / 36025
• FlyBaseID: FBgn0033460
• Length: 1184
• Species: Drosophila melanogaster
• Sequence 2: NP_001287742.1
• Gene: SEC24B / 10427
• HGNCID: 10704
• Length: 1298
• Species: Homo sapiens
• Alignment Length: 1324
• Identity: 534/1324 - (40%)
• Similarity: 727/1324 - (54%)
• Gaps: 187/1324 - (14%)

  Fly    10 PPAHAPMPLN-GNNFVNGVQGSVQQQPGPPPGQQ------YIPQKQPQQFQQPP--PAAAFPGAG 65
            |.|.|.:|.. |...|:|.........||.|.||      ::.|.. .:...|.  ||:|...||
Human    10 PAASARIPPKFGGAAVSGAAAPAGPGAGPAPHQQNETGFHHVAQAS-LELLDPSNLPASASQIAG 73

  Fly    66 APGNVPPPQQFNSGI---TNQFLPPTS------GAAT------------------PLQQLPPSTL 103
            :.|......|..||.   ...::.|:.      |..|                  |.|.:.|:|:
Human    74 STGPAQNQMQVPSGYGLHHQNYIAPSGHYSQGPGKMTSLPLDTQCGDYYSALYTVPTQNVTPNTV 138

  Fly   104 --PPHLRPPAANGPPL------TNGS--NGASSANSSRTASPRPVGAAPQYAQGPIAAALNNPPL 158
              .|..:...:.|||.      |.||  ..||||:...|::.:|..:...:...|...:.::...
Human   139 NQQPGAQQLYSRGPPAPHIVGSTLGSFQGAASSASHLHTSASQPYSSFVNHYNSPAMYSASSSVA 203

  Fly   159 ASGLRPS---------------PQPTHQSL-------ANLTSNLENLNLNTTR-------ANGGT 194
            :.|. ||               |..::.||       ...||.    |..|.|       :...|
Human   204 SQGF-PSTCGHYAMSTVSNAAYPSVSYPSLPAGDTYGQMFTSQ----NAPTVRPVKDNSFSGQNT 263

  Fly   195 SI--------LPQPQTQQQYA----PTVTQKDGRGVASAQTGPPQFNDANSLLAASGVAAALVPN 247
            :|        ||..|..||.:    .|:|. ...|:.|.|....: |...||..|:......|.:
Human   264 AISHPSPLPPLPSQQHHQQQSLSGYSTLTW-SSPGLPSTQDNLIR-NHTGSLAVANNNPTITVAD 326

  Fly   248 AMATP-FSGQKPPNLAPNPAKMF-GSASMAGRPTPAGQRIPYGVPPPTN---PEQQSQQ------ 301
            :::.| ....:||..:|..:.:. ||:..:...||.....|  |.|.|:   |.:..||
Human   327 SLSCPVMQNVQPPKSSPVVSTVLSGSSGSSSTRTPPTANHP--VEPVTSVTQPSELLQQKGVQYG 389

  Fly   302 ---NNNLQNAPPP-------------PRVGAVWPPSLPNVAAP----------GAQPMM------ 334
               ||...:||.|             .....|...|..:.|:|          |:.|.|
Human   390 EYVNNQASSAPTPLSSTSDDEEEEEEDEEAGVDSSSTTSSASPMPNSYDALEGGSYPDMLSSSAS 454

  Fly   335 -PPAQQTPQTYPYSQVYQPGPQQQPPP--PQSAVQPPPPGMFGTQPTGAPLQYQAQAPPQAYGQH 396
             |.....|:..|.|   .|.|...|.|  ||.:....|.| :| .||..| .||....|...|..
Human   455 SPAPDPAPEPDPAS---APAPASAPAPVVPQPSKMAKPFG-YG-YPTLQP-GYQNATAPLISGVQ 513

  Fly   397 P--------QQAPQTAPGGPYGTTAPLNVAQQGFSRLWGQDTIDLMQNRHIL--TPATLPPPKVV 451
            |        ||.|| .||....:::...::.|...:......::|.|.|:||  ||...|.|.:
Human   514 PSNPVYSGFQQYPQ-YPGVNQLSSSIGGLSLQSSPQPESLRPVNLTQERNILPMTPVWAPVPNL- 576

  Fly   452 LHNQFHESINCSPSIMRCTLTKIPESNSLLQKSRLPLGIVIHPFRDVNSLPVIQCINIVRCRLCR 516
              |...:.:||||...|||||.||::.:||.|::||||:::|||||:..||||....|||||.||
Human   577 --NADLKKLNCSPDSFRCTLTNIPQTQALLNKAKLPLGLLLHPFRDLTQLPVITSNTIVRCRSCR 639

  Fly   517 TYINPFVYFVDSKMWKCNLCYRVNELPDDFQFDPATKTYGDVTRRPEVRSSTIEFIAPSEYMLRP 581
            |||||||.|:|.:.||||||||||::|::|.::|.|::||:..:||||::||:||||.|:|||||
Human   640 TYINPFVSFIDQRRWKCNLCYRVNDVPEEFMYNPLTRSYGEPHKRPEVQNSTVEFIASSDYMLRP 704

  Fly   582 PQPAMYLFLFDVSIIAQQSGYLEAACAVLNRHLDEMPGDARTQVGFICFDSFVHFYSMAEGLNQP 646
            ||||:|||:.|||..|.::|||...|..|..:||::|||:||::||:.|||.:|||::.|||:||
Human   705 PQPAVYLFVLDVSHNAVEAGYLTILCQSLLENLDKLPGDSRTRIGFMTFDSTIHFYNLQEGLSQP 769

  Fly   647 HEMTLLDIEDPFLPRPDSLLVNLKECKELVRDLLKQLPKRFAHTHDPGSALGAALQVAFKLMQAS 711
            ..:.:.||:|.|||.||||||||.|.|||::|||..||..|.:|.:..||||.|||.|||||..:
Human   770 QMLIVSDIDDVFLPTPDSLLVNLYESKELIKDLLNALPNMFTNTRETHSALGPALQAAFKLMSPT 834

  Fly   712 GGRITVFQSCLPNKGPGALEPREDPNNRSA-KDVAHLNPATDFYKRFALECSGYQIACDLFLMNQ 775
            |||::|||:.||:.|.|.|:.|||||.||: |.|.||.|||||||:.||:|||.|.|.||||::.
Human   835 GGRVSVFQTQLPSLGAGLLQSREDPNQRSSTKVVQHLGPATDFYKKLALDCSGQQTAVDLFLLSS 899

  Fly   776 QYSDMATISGISKHSGGCVHHFPLYQKT-KPHMVESFRSCFKRYLTRKIGFEAVMRIRCTRGLQV 839
            ||||:|:::.:||:|.||::::|.:..| .|...|..:...|||||||||||||||||||:||.:
Human   900 QYSDLASLACMSKYSAGCIYYYPSFHYTHNPSQAEKLQKDLKRYLTRKIGFEAVMRIRCTKGLSM 964

  Fly   840 HTFHGNFFVRSTDLLSLPNVNPDAGYGMQISYEESLTDAKTICFQAALLYTNSEGERRIRVHTVC 904
            |||||||||||||||||.|:|||||:.:|:|.||||||...:|||.|||||:|:|||||||||:|
Human   965 HTFHGNFFVRSTDLLSLANINPDAGFAVQLSIEESLTDTSLVCFQTALLYTSSKGERRIRVHTLC 1029

  Fly   905 LPVTASLPEVMHSADTEAIIGLLSKMAVDRSVASNLSDARDAFINATIDVYNAF-KIAQNLPSGQ 968
            |||.:||.:|....|.:|.|.||:.|||||||:|:|||||||.:||.:|..:|: ....||   |
Human  1030 LPVVSSLADVYAGVDVQAAICLLANMAVDRSVSSSLSDARDALVNAVVDSLSAYGSTVSNL---Q 1091

  Fly   969 SGQLIAPRSLALLPLYILALLKHPAFRVGTSTRLDDRVYAMDCMKTLPLDQLMKYVYPELYKIDA 1033
            ...|:||.||.|.|||:|||||..|||.|||||||||||||..:|:.||..|||.::|.||:||.
Human  1092 HSALMAPSSLKLFPLYVLALLKQKAFRTGTSTRLDDRVYAMCQIKSQPLVHLMKMIHPNLYRIDR 1156

  Fly  1034 LIYHARNSNISSNQDDDED----EDEPLPELPRLQLSAEHLDSRSIFLMDCGTLIMIYVGLNVPP 1094
            |              .||.    .|..:|:.|..:||||.|.....||||||::..|:||.....
Human  1157 L--------------TDEGAVHVNDRIVPQPPLQKLSAEKLTREGAFLMDCGSVFYIWVGKGCDN 1207

  Fly  1095 DVLEAVLGISSTAELGDYVYGLPNVVSNENDVLKRFILRLNYDKPYSALVQIIRDTSTAKGQFTE 1159
            :.:|.|||.::.|.:...:..||.:.:..::..:.||..|...:|.|.::.|::|.|.||.:|.:
Human  1208 NFIEDVLGYTNFASIPQKMTHLPELDTLSSERARSFITWLRDSRPLSPILHIVKDESPAKAEFFQ 1272

  Fly  1160 RLTDDRSESSLSYYEFLQHIRAQV 1183
            .|.:||:|::.||||||.|::.|:
Human  1273 HLIEDRTEAAFSYYEFLLHVQQQI 1296

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec24AB	NP_610531.1	PHA03247	<72..426	CDD:223021	107/485 (22%)
		COG5028	383..1184	CDD:227361	419/818 (51%)
SEC24B	NP_001287742.1	COG5028	584..1289	CDD:227361	393/721 (55%)