Protein Alignment Sec24AB and sec24d

DIOPT Version :10

• Sequence 1: NP_610531.1
• Gene: Sec24AB / 36025
• FlyBaseID: FBgn0033460
• Length: 1184
• Species: Drosophila melanogaster
• Sequence 2: XP_002934294.1
• Gene: sec24d / 100494048
• XenbaseID: XB-GENE-977055
• Length: 1024
• Species: Xenopus tropicalis
• Alignment Length: 1060
• Identity: 276/1060 - (26%)
• Similarity: 465/1060 - (43%)
• Gaps: 117/1060 - (11%)

  Fly   196 ILPQPQTQQQ-----YAPTVTQKDGRGVASAQTGPPQFNDANSLLAASGVAAALVPNAMATPFSG 255
            :.|.|.:|.|     |.|        |..|....||..|...: ...:....|::.:|::  |..
 Frog     7 VAPPPFSQSQPGLGGYPP--------GYGSPMMSPPYANYGGT-SPTNPTQPAMLKSAVS--FGS 60

  Fly   256 QKP---PNLAPNPAKMFGSAS------MAGRPTPAGQRI---PYGVPP-------PTNPEQQSQQ 301
            |.|   |..|||.::...:.|      :.|.|.|.....   |||.||       ||...|.:.|
 Frog    61 QPPLNTPTSAPNNSQNGPNFSGNIMPRVHGPPAPNNTSFSYPPYGHPPSHTNSTVPTPVHQVTNQ 125

  Fly   302 NNNLQ--NAPPPPRVGAVWPPSLPNVAA-PG-AQPM--------MPPAQQTPQTYPYSQVYQPGP 354
            .||:|  |..||....:..||..|..|| || .:||        .||........|.....|.|.
 Frog   126 LNNMQIGNYGPPSSSSSQIPPGPPMPAAYPGQTRPMPVPPGPYFPPPLSNNQNGLPSEPFLQTGN 190

  Fly   355 QQQ------------PPPPQSAVQPPPPGMFGTQPTGAPLQYQAQAPPQAYGQHPQQA-PQTAPG 406
            .|:            ...||....||....:|.|..|:.|.|....|    |..||.: |.....
 Frog   191 MQEGIAGHQNFLSQNQAQPQIGYPPPNSNNYGGQLPGSTLSYPGAFP----GNQPQMSGPPQRKT 251

  Fly   407 GPYGTTAPLNVAQQGFSRLWGQDTIDLMQNRHILTPATLPPPKVVLHNQFHESINCSPSIMRCTL 471
            .|....:|:.|..        .|.|:.....:........||.|.......:..|.||..:|||.
 Frog   252 DPDSIPSPIQVID--------SDKINRAGQVYTTNVRGQVPPLVTTECTIQDQGNASPRYIRCTT 308

  Fly   472 TKIPESNSLLQKSRLPLGIVIHPFRDV--NSLPVIQCIN-----IVRCRLCRTYINPFVYFVD-S 528
            ...|.|:.:.::|::||.:||.|...|  |..| |..:|     .:||..|:.|:.||:.|:: .
 Frog   309 YCFPTSSDMAKQSQIPLAVVIKPLAVVPKNETP-IYIVNHGETGPIRCNRCKAYMCPFMQFIEGG 372

  Fly   529 KMWKCNLCYRVNELPD-DFQFDPATKTYGDVTRRPEVRSSTIEFIAPSEYML--RPPQPAMYLFL 590
            :.:.|..|..||::|. .||.........|...|||:...:.|::|..:|..  :||.|..|:|:
 Frog   373 RRYHCGFCSCVNDVPPFYFQHLDHIGRRVDHFERPELSLGSYEYVATLDYCRKNKPPNPPAYIFM 437

  Fly   591 FDVSIIAQQSGYLEAACAVLNRHLDEMPGDARTQ-----VGFICFDSFVHFYSMAEGLNQPHEMT 650
            .|||....::|.:...|..|...|:.:|.:...:     |||:.::..:|||::...|.||..|.
 Frog   438 IDVSYNNIKNGVVRLICEELKILLENLPREENAESSAIRVGFVTYNKVLHFYNVNSNLAQPQMMV 502

  Fly   651 LLDIEDPFLPRPDSLLVNLKECKELVRDLLKQLPKRFAHTHDPGSALGAALQVAFKLMQASG--G 713
            :.|..:.|||..|..|||..|.|.::.:||.|:|:.||.|::..:.....:|...:.::||.  |
 Frog   503 VTDTAEVFLPLLDGFLVNFNESKSVINNLLSQIPEMFADTNESETVFAPIIQAGMEALKASECVG 567

  Fly   714 RITVFQSCLPN-KGPGALEPREDPN--NRSAKDVAHLNPATDFYKRFALECSGYQIACDLFLMNQ 775
            ::.:|||.||. :.||.|..|:|..  |...:.:..: |.::.|:..|.||.......||||...
 Frog   568 KLFIFQSSLPTAEAPGKLRNRDDRKLVNTEKEKILFM-PQSNVYENLAKECVANGCCVDLFLFPN 631

  Fly   776 QYSDMATISGISKHSGGCVHHFPLYQKTKPHMVESFRSCFKRYLTRKIGFEAVMRIRCTRGLQVH 840
            |:.|:|::..::..:||.::.:..:|.....  :.|.|..::.:.:.:||:|:||:|.:.|.:..
 Frog   632 QHIDVASMGIVTMQTGGTLYKYSQFQVHTDG--QQFISDLRKDIEKHVGFDAIMRVRTSTGFRAT 694

  Fly   841 TFHGNFFVRSTDLLSLPNVNPDAGYGMQISYEESLTDAKTICFQAALLYTNSEGERRIRVHTVCL 905
            .|.|..::.:|..:.:..|:.|....::..:::.|::......|.|||||:..|:||:.:|.:.|
 Frog   695 DFFGGIYMSNTSDVEMAGVDCDKAVTVEFKHDDKLSEDTGALIQCALLYTSISGQRRLLIHNISL 759

  Fly   906 PVTASLPEVMHSADTEAIIGLLSKMAVDRSVASNLSDARDAFINATIDVYNAFKIAQNLPSGQSG 970
            ..::.:.::..|.:|:.:|...:|.|....:...|...||..|:.|..:...::.....||..|
 Frog   760 NCSSQMADIYKSCETDVLINFFAKSAYKAMLHHPLKTVRDVLISQTAHMLACYRKNCASPSAVS- 823

  Fly   971 QLIAPRSLALLPLYILALLKHPAFRVGTSTRLDDRVYAMDCMKTLPLDQLMKYVYPELYKIDALI 1035
            |||.|.|:.|||:|:..|||:...........|:|.:....:..:.:.....:.||:|..|..:
 Frog   824 QLILPDSMKLLPVYMNCLLKNEVLIGSPEVPTDERTFQRQLVMCMDVASSQIFFYPQLLPIHTM- 887

  Fly  1036 YHARNSNISSNQDDDEDEDEPLPELPRLQLSAEHLDSRSIFLMDCGTLIMIYVGLNVPPDVLEAV 1100
                         |.:|:..|.|    ::.|.|.|....|||:..|..:.:::|.|.||:.::.:
 Frog   888 -------------DLKDDTIPTP----VRCSEERLSEGGIFLLANGINMFLWLGFNSPPEFIQGI 935

  Fly  1101 LGISSTAELGDYVYGLPNVVSNENDVLKRFILRLNYDKPYSALVQIIRDTSTAKGQFTERLTDDR 1165
            ..:.|.|.:......||.|.|..:..|:..:..:....|||..:.:::....|:..|.:.|.:|:
 Frog   936 FNVPSFAHITPEATSLPAVDSAHSKKLRSIMDAIQKTCPYSMKLILVKQKDKAEMGFRQMLVEDK 1000

  Fly  1166 S-ESSLSYYEFLQHIRAQVK 1184
            . ....||.:||..:..:::
 Frog  1001 GLLGGASYMDFLCCVHKEIR 1020

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec24AB	NP_610531.1	PHA03247	<72..426	CDD:223021	71/278 (26%)
		COG5028	383..1184	CDD:227361	214/823 (26%)
sec24d	XP_002934294.1	Med15	<35..>258	CDD:312941	59/229 (26%)
		COG5028	157..1020	CDD:227361	230/897 (26%)