DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lime and Zfp423

DIOPT Version :9

Sequence 1:	NP_610529.1	Gene:	Lime / 36023	FlyBaseID:	FBgn0033458	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_001380647.1	Gene:	Zfp423 / 94188	RGDID:	621664	Length:	1292	Species:	Rattus norvegicus

Alignment Length:	621	Identity:	102/621 - (16%)
Similarity:	185/621 - (29%)	Gaps:	243/621 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 QTEP-KRHPAKMYPQIP-----SAIPSPPFSPTDPTDMPLVKEILARSEHINVPEGTVLCVPCYL 83
            |||. ::|...::||:.     ..|..|.....:.|.:..:.:..|..:|           .|.:
  Rat   282 QTEELEKHVLTLHPQLSEKADLQCIHCPEVFVDESTLLAHIHQAHANQKH-----------KCPM 335

  Fly    84 CKQPFNDIESFKEHLTQH-------------------AAEINAWNNTRAQEQ---TPPPTITPF- 125
            |.:.|:.:|....||..|                   |:..:|..::.|..:   ||..|:.|.
  Rat   336 CPEQFSSVEGVYCHLDSHRQPDSSNHSVSPDPVLGSVASMSSATPDSSASVERGSTPDSTLKPLR 400

  Fly   126 --------VQSMNK-----PF------------------VHPTDQHLFHS----IDHGDMDHHHN 155
                    .||.:|     |:                  :|.......|:    :|.....::.|
  Rat   401 GQKKMRDDGQSWSKVVYSCPYCSKRDFTSLAVLEIHLKTIHADKPQQSHTCQICLDSMPTLYNLN 465

  Fly   156 AHYRNRMEFGCPPPMDF---------YSPPLEPEIPFQMPAV---HQHPIQIPP----------- 197
            .|.|...:....|.|.|         |.|.:..:|......:   |..|...||
  Rat   466 EHVRKLHKSHAYPVMQFGNISAFHCNYCPEMFADINSLQEHIRVSHCGPNANPPDGNNAFFCNQC 530

  Fly   198 ----------------MYMTAQHTAYEPPVQFLGHRPLELRQKL---PMSPQSPLEPSGHPMASA 243
                            .:.:...|..|.||    .:|.:...::   |....||:      ..|.
  Rat   531 SMGFLTESSLTEHIQQAHCSVGSTKLESPV----IQPTQSFMEVYSCPYCTNSPI------FGSI 585

  Fly   244 IPSNQHTSLEMQNLCVPEGILTRVEEPPVLENPRPQAQDPIQDAGAGKSRSAVLIEPKPPNAKSL 308
            :...:|.....:|:.:.....::.|:.||..:  .:...|.:...:|.:.|
  Rat   586 LKLTKHIKENHKNIPLAHSKKSKAEQSPVSSD--VEVSSPKRQRLSGSANS-------------- 634

  Fly   309 AFNQGQFECNWCGKRLSSRQSLKYH-----------------ESHFHGNKEL------------- 343
             .:.|::.||.|..:.|:.:|.:.|                 :..|...:.|
  Rat   635 -ISNGEYPCNQCDLKFSNFESFQTHLKLHLELLLRKQACPQCKEDFDSQESLLQHLTVHYMTTST 698

  Fly   344 ------------AVNRLEKNLTKQH-----KCLTCKKRYKRRTFLLMHMKVKHGIAFPGRVN--- 388
                        :|:.|:|:|...|     .|..|::.:..:..:.:|:.|||.       |
  Rat   699 HYVCESCDKQFSSVDDLQKHLLDMHTFVLYHCTLCQEVFDSKVSIQVHLAVKHS-------NEKK 756

  Fly   389 ------ADPEYPKSVDSPVSAKVPVSPMSSPNEAPK----KEIWSTRI----------------- 426
                  .:.::.|..|..|..|  .|.:.:|.:|.|    .|.:||.:
  Rat   757 MYRCTACNWDFRKEADLQVHVK--HSHLGNPAKAHKCIFCGETFSTEVELQCHITTHSKKYNCRF 819

  Fly   427 ----FNAVAAAK---------YQPASERADKYLVAP 449
                |:||...:         :.||:|......|.|
  Rat   820 CSKAFHAVLLLEKHLREKHCVFDPAAENGTANGVPP 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lime	NP_610529.1	C2H2 Zn finger	317..336	CDD:275368	6/35 (17%)
Lime	NP_610529.1	C2H2 Zn finger	358..377	CDD:275368	3/18 (17%)
Zfp423	NP_001380647.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	34..70
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..123
		C2H2 Zn finger	148..168	CDD:275368
		C2H2 Zn finger	176..196	CDD:275368
		COG5048	202..603	CDD:227381	56/341 (16%)
		C2H2 Zn finger	204..224	CDD:275368
		C2H2 Zn finger	232..252	CDD:275368
		C2H2 Zn finger	273..292	CDD:275368	4/9 (44%)
		C2H2 Zn finger	419..440	CDD:275368	1/20 (5%)
		C2H2 Zn finger	451..475	CDD:275368	4/23 (17%)
		C2H2 Zn finger	490..509	CDD:275368	3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	598..635		7/53 (13%)
		C2H2 Zn finger	672..692	CDD:275368	2/19 (11%)
		C2H2 Zn finger	702..723	CDD:275368	4/20 (20%)
		C2H2 Zn finger	730..751	CDD:275368	4/20 (20%)
		C2H2 Zn finger	760..781	CDD:275368	4/22 (18%)
		C2H2 Zn finger	791..811	CDD:275368	3/19 (16%)
		C2H2 Zn finger	817..835	CDD:275368	3/17 (18%)
		C2H2 Zn finger	896..917	CDD:275368
		C2H2 Zn finger	940..960	CDD:275368
		C2H2 Zn finger	969..989	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1144..1171
		C2H2 Zn finger	1208..1228	CDD:275368
		C2H2 Zn finger	1239..1260	CDD:275368
		C2H2 Zn finger	1269..1285	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24408
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100