DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lime and Zfp423

DIOPT Version :9

Sequence 1:	NP_610529.1	Gene:	Lime / 36023	FlyBaseID:	FBgn0033458	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	XP_011246862.1	Gene:	Zfp423 / 94187	MGIID:	1891217	Length:	1312	Species:	Mus musculus

Alignment Length:	529	Identity:	95/529 - (17%)
Similarity:	170/529 - (32%)	Gaps:	164/529 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDAESDSDVEIIETELMNHHHHHRQTEPKRHPAKMYP------QIPSAIPSPPF-----SPTDPT 54
            |..|..|.||.:..    |...|||.:...|.....|      .:.||.|....     |..|.|
Mouse   355 MCPEQFSSVEGVYC----HLDSHRQPDSSNHSVSPDPVLGSVASMSSATPDSSASVERGSTPDST 415

  Fly    55 DMPLVKEILARSEHINVPEGTVLCVPCYLCKQPFNDIESFKEHL-TQHAAEINAWNNTRAQEQTP 118
            ..||..:...|.:..:.|:....|.  |..|:.|..:...:.|| |.||.:....:..:....:.
Mouse   416 LKPLRGQKKMRDDGQSWPKVVYSCP--YCSKRDFTSLAVLEIHLKTIHADKPQQSHTCQICLDSM 478

  Fly   119 PP--TITPFVQSMNKPFVHPTDQ----HLFHS-------IDHGDMDHH---------------HN 155
            |.  .:...|:.::|...:|..|    ..||.       .|...:..|               :|
Mouse   479 PTLYNLNEHVRKLHKSHAYPVMQFGNISAFHCNYCPEMFADINSLQEHIRVSHCGPNANPPDGNN 543

  Fly   156 AHYRNRMEFGCPPPMDFYSPPLEPEIPFQMPAVHQHPIQIPPMYMTAQHTAYEPPVQFLGHRPLE 220
            |.:.|:...|      |.:.          .::.:|   |...:.:...|..|.||.    :|.:
Mouse   544 AFFCNQCSMG------FLTE----------SSLTEH---IQQAHCSVGSTKLESPVV----QPTQ 585

  Fly   221 LRQKL---PMSPQSPLEPSGHPMASAIPSNQHTSLEMQNLCVPEGILTRVEEPPVLENPRPQAQD 282
            ...::   |....||:      ..|.:...:|.....:|:.:.....::.|:.||..:  .:...
Mouse   586 SFMEVYSCPYCTNSPI------FGSILKLTKHIKENHKNIPLAHSKKSKAEQSPVSSD--VEVSS 642

  Fly   283 PIQDAGAGKSRSAVLIEPKPPNAKSLAFNQGQFECNWCGKRLSSRQSLKYH-------------- 333
            |.:...:|.:.|               .:.|::.||.|..:.|:.:|.:.|
Mouse   643 PKRQRLSGSANS---------------ISNGEYPCNQCDLKFSNFESFQTHLKLHLELLLRKQAC 692

  Fly   334 ---ESHFHGNKEL-------------------------AVNRLEKNLTKQH-----KCLTCKKRY 365
               :..|...:.|                         :|:.|:|:|...|     .|..|::.:
Mouse   693 PQCKEDFDSQESLLQHLTVHYMTTSTHYVCESCDKQFSSVDDLQKHLLDMHTFVLYHCTLCQEVF 757

  Fly   366 KRRTFLLMHMKVKHGIAFPGRVN---------ADPEYPKSVDSPVSAKVPVSPMSSPNEAPK--- 418
            ..:..:.:|:.|||.       |         .:.::.|..|..|..|  .|.:.:|.:|.|
Mouse   758 DSKVSIQVHLAVKHS-------NEKKMYRCTACNWDFRKEADLQVHVK--HSHLGNPAKAHKCIF 813

  Fly   419 -KEIWSTRI 426
             .|.:||.:
Mouse   814 CGETFSTEV 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lime	NP_610529.1	C2H2 Zn finger	317..336	CDD:275368	6/35 (17%)
Lime	NP_610529.1	C2H2 Zn finger	358..377	CDD:275368	3/18 (17%)
Zfp423	XP_011246862.1	C2H2 Zn finger	168..188	CDD:275368
		C2H2 Zn finger	196..216	CDD:275368
		COG5048	222..623	CDD:227381	57/302 (19%)
		C2H2 Zn finger	224..244	CDD:275368
		C2H2 Zn finger	252..272	CDD:275368
		C2H2 Zn finger	293..312	CDD:275368
		C2H2 Zn finger	439..460	CDD:275368	6/22 (27%)
		C2H2 Zn finger	471..495	CDD:275368	3/23 (13%)
		C2H2 Zn finger	510..529	CDD:275368	2/18 (11%)
		C2H2 Zn finger	692..712	CDD:275368	2/19 (11%)
		C2H2 Zn finger	722..743	CDD:275368	4/20 (20%)
		C2H2 Zn finger	750..771	CDD:275368	4/20 (20%)
		C2H2 Zn finger	780..801	CDD:275368	4/22 (18%)
		C2H2 Zn finger	811..831	CDD:275368	3/12 (25%)
		C2H2 Zn finger	837..855	CDD:275368
		C2H2 Zn finger	916..937	CDD:275368
		C2H2 Zn finger	960..980	CDD:275368
		C2H2 Zn finger	989..1009	CDD:275368
		C2H2 Zn finger	1228..1248	CDD:275368
		C2H2 Zn finger	1259..1280	CDD:275368
		C2H2 Zn finger	1289..1305	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24408
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100