DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lime and PLAGL2

DIOPT Version :9

Sequence 1:	NP_610529.1	Gene:	Lime / 36023	FlyBaseID:	FBgn0033458	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_002648.1	Gene:	PLAGL2 / 5326	HGNCID:	9047	Length:	496	Species:	Homo sapiens

Alignment Length:	421	Identity:	82/421 - (19%)
Similarity:	131/421 - (31%)	Gaps:	172/421 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 PFQMPAVHQHPIQIPPMYM-------------TAQHTAYEPP----VQFLGHRPLELRQKLPMSP 229
            |..:|...|.|...|.::.             .|.|:|.:|.    ...:.||...||..|  ..
Human    57 PHSLPQPEQRPYSCPQLHCGKAFASKYKLYRHMATHSAQKPHQCMYCDKMFHRKDHLRNHL--QT 119

  Fly   230 QSPLEPSGHPMASAIPSNQHTSLEMQ-----------NLCVPEGILTRVEEPPVLENPRPQAQDP 283
            ..|.:.:.|  .|....|.:|.|..:           :|.....:.|......:||:.:..::
Human   120 HDPNKEALH--CSECGKNYNTKLGYRRHLAMHAASSGDLSCKVCLQTFESTQALLEHLKAHSR-- 180

  Fly   284 IQDAGAGKSRSAVLIEPKPPNAKSLAFNQGQFECNWCGKRLSSRQSLKYHESHFHGNKELAVNRL 348
             :.||..|       |.|.|             |:.|.:|..:|:.::.|.....|.|:..
Human   181 -RVAGGAK-------EKKHP-------------CDHCDRRFYTRKDVRRHLVVHTGRKDFL---- 220

  Fly   349 EKNLTKQHKCLTCKKRYKRRTFLLMHMKVKH---------------GI----------------- 381
                     |..|.:|:.|:..|..|:|..|               |:
Human   221 ---------CQYCAQRFGRKDHLTRHVKKSHSQELLKIKTEPVDMLGLLSCSSTVSVKEELSPVL 276

  Fly   382 -----------AFPGRVNAD------PEYPKS------VDS--PVSAKVPV--SPMSSPNEAPKK 419
                       ||||.:...      |..|.:      |.:  |:....|:  ||:|||.:.|.|
Human   277 CMASRDVMGTKAFPGMLPMGMYGAHIPTMPSTGVPHSLVHNTLPMGMSYPLESSPISSPAQLPPK 341

  Fly   420 -EIWSTRIFN-------------------AVAAAKYQPASER-------ADKYLVA--PRQQTEQ 455
             ::.||....                   ::::|:.||||.:       .|:.|:|  |...:|.
Human   342 YQLGSTSYLPDKLPKVEVDSFLAELPGSLSLSSAEPQPASPQPAAAAALLDEALLAKSPANLSEA 406

  Fly   456 LES---------GFTITSKRTYPLRSPYFNP 477
            |.:         ||       .||..|..||
Human   407 LCAANVDFSHLLGF-------LPLNLPPCNP 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lime	NP_610529.1	C2H2 Zn finger	317..336	CDD:275368	5/18 (28%)
Lime	NP_610529.1	C2H2 Zn finger	358..377	CDD:275368	6/18 (33%)
PLAGL2	NP_002648.1	C2H2 Zn finger	70..92	CDD:275368	2/21 (10%)
		zf-H2C2_2	85..109	CDD:404364	4/23 (17%)
		C2H2 Zn finger	100..120	CDD:275368	5/21 (24%)
		C2H2 Zn finger	129..149	CDD:275368	4/19 (21%)
		C2H2 Zn finger	158..178	CDD:275368	3/19 (16%)
		C2H2 Zn finger	193..213	CDD:275368	5/19 (26%)
		C2H2 Zn finger	221..239	CDD:275368	6/17 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24408
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100