DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lime and ZNF787

DIOPT Version :9

Sequence 1:	NP_610529.1	Gene:	Lime / 36023	FlyBaseID:	FBgn0033458	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_001002836.2	Gene:	ZNF787 / 126208	HGNCID:	26998	Length:	382	Species:	Homo sapiens

Alignment Length:	353	Identity:	74/353 - (20%)
Similarity:	116/353 - (32%)	Gaps:	117/353 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 YSP-PLEPEIPFQMPAVHQHPIQIPPMYMTAQHTAYEPPVQFLGHRPLELRQKLPMSPQSPLEPS 236
            :|| ||:.|  .|..|.|::|:.|  :.|........||.:              :||.....|:
Human     8 WSPGPLDSE--DQQMASHENPVDI--LIMDDDDVPSWPPTK--------------LSPPQSAPPA 54

  Fly   237 GHPMASAIP----------SNQHTSLEMQNLCVPEGILTRVEEPPVLENPRPQAQDPIQDAGAGK 291
            |.|.....|          |..|.|.           |||.:.....|.|...|     |.|...
Human    55 GPPPRPRPPAPYICNECGKSFSHWSK-----------LTRHQRTHTGERPNACA-----DCGKTF 103

  Fly   292 SRSAVLIEPKPPNAKSLAFNQGQFECNWCGKRLSSRQSLKYHE---------------SHFHGNK 341
            |:|:.|::     .:.:...:..:.|..||||.|...:|..|:               ..|..:|
Human   104 SQSSHLVQ-----HRRIHTGEKPYACLECGKRFSWSSNLMQHQRIHTGEKPYTCPDCGRSFTQSK 163

  Fly   342 ELAVNRLEKNLTKQHKCLTCKKRYKRRTFLLMHMKVKHGIAFPG----------RVNADPEYPKS 396
            .||.:|...:..|...|..|.:.:.:...|..|:::...::.||          |....||...:
Human   164 SLAKHRRSHSGLKPFVCPRCGRGFSQPKSLARHLRLHPELSGPGVAAKVLAASVRRAKGPEEAVA 228

  Fly   397 VDSPVSAKVPVSP------MSSPNEAPKKEIWSTRIFNAVAAAKYQPASERADKYLVAPRQQTEQ 455
            .|..::  :||..      :.:|.|            .|.|||....|..:|    ..||.:
Human   229 ADGEIA--IPVGDGEGIIVVGAPGE------------GAAAAAAMAGAGAKA----AGPRSR--- 272

  Fly   456 LESGFTITSKRTYPLRSPYFNPDLWLDC 483
                           |:|...|.:.|:|
Human   273 ---------------RAPAPKPYVCLEC 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lime	NP_610529.1	C2H2 Zn finger	317..336	CDD:275368	8/33 (24%)
Lime	NP_610529.1	C2H2 Zn finger	358..377	CDD:275368	4/18 (22%)
ZNF787	NP_001002836.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..65		19/74 (26%)
		COG5048	<67..200	CDD:227381	32/153 (21%)
		C2H2 Zn finger	68..88	CDD:275368	6/30 (20%)
		C2H2 Zn finger	96..116	CDD:275368	6/29 (21%)
		C2H2 Zn finger	124..144	CDD:275368	8/19 (42%)
		C2H2 Zn finger	152..172	CDD:275368	5/19 (26%)
		C2H2 Zn finger	180..200	CDD:275368	4/19 (21%)
		C2H2 Zn finger	282..302	CDD:275368	2/4 (50%)
		C2H2 Zn finger	319..339	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	357..382
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24408
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100