DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lime and Zbtb21

DIOPT Version :9

Sequence 1:	NP_610529.1	Gene:	Lime / 36023	FlyBaseID:	FBgn0033458	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_780637.2	Gene:	Zbtb21 / 114565	MGIID:	1927240	Length:	1094	Species:	Mus musculus

Alignment Length:	474	Identity:	90/474 - (18%)
Similarity:	162/474 - (34%)	Gaps:	140/474 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 TDPTDMPLVKEILARSEHINVPEGTVLCVPCYLCKQPFNDIESFKEHLTQHAAEINAWNNTRAQE 115
            :.|....:.:.:.:|:      :|..:|.   .|.:.:..:..||:|:..|..| .....:||.:
Mouse   682 SSPAQQVIKRNLRSRA------KGAYICA---YCGKAYRFLSQFKQHIKMHPGE-RPLGVSRAAK 736

  Fly   116 QTPPPTITPFVQSMNKPFVHP---TDQHLFHSIDHGDMDHHHNAHYRNRMEFGCP-PPMDFYSPP 176
                |......:::....|:|   .:..|...::.|    :|....||...  || ..:.|:||.
Mouse   737 ----PKERALARAVENKEVYPCRLCNAKLSSLLEQG----NHERLCRNATV--CPYCSLRFFSPA 791

  Fly   177 LEPEIPFQMPAVHQHPIQIPPMYMTAQHTAYEPPVQFLGHRPLELRQKLPMS-----PQSPLEPS 236
            |:.|        |:...:...:........::.......|: :|:..:..|:     ..:.|:.:
Mouse   792 LKQE--------HEDRCEYKKLTCLECMRTFKSSFSIWRHQ-VEVHNQNNMALAENFALATLDHN 847

  Fly   237 GHPMASAIPSNQHT----------------SLEMQNL------CVPEG------ILTRVEEPPV- 272
            |...|::.|..:.:                |.|..|.      |:||.      :..:|:|.||
Mouse   848 GEVAAASRPQTEPSKVNHVATPKEDTAFSDSSEQVNFDSEDSSCLPEDLSLSKQLKVQVKEEPVE 912

  Fly   273 -LENPRPQAQDPIQDAGAGKSRSAVLIEPKPPNAKSLAFNQGQFECNWCGKRLSSRQSLKYHESH 336
             .|...|:|....::||..|                   ..|.:.|..|||..::.:.|:.|:
Mouse   913 EAEEEAPEASAAPREAGPSK-------------------ETGLWPCEKCGKMFTAHKQLERHQ-- 956

  Fly   337 FHGNKELAVNRLEKNLTKQHKCLTCKKRYKRRTFLLMHMKVKHGIAFPGRVNADPEY-PKSVDSP 400
                 ||..:      .|...|..|.|.::....|..|.:.....|....|..:.|. |...:||
Mouse   957 -----ELLCS------VKPFICHVCYKAFRTNFRLWSHFQTHMSQATEEPVQKESEVCPVPTNSP 1010

  Fly   401 VSAKVP-------VSPM--SSPNEAPKKEIWSTRIFNAVAAAKYQPASERADKYLVAPRQQTEQL 456
            ....:|       :.|:  .||...|:..               .||:|:    |.|| |:::.|
Mouse  1011 SPPPLPPPPPLPKIQPLEPDSPTGLPENP---------------TPATEK----LFAP-QESDTL 1055

  Fly   457 ESGF-------TITSKRTY 468
               |       .||.||.:
Mouse  1056 ---FYHAPPLSAITFKRQF 1071

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lime	NP_610529.1	C2H2 Zn finger	317..336	CDD:275368	6/18 (33%)
Lime	NP_610529.1	C2H2 Zn finger	358..377	CDD:275368	5/18 (28%)
Zbtb21	NP_780637.2	BTB_POZ_ZBTB21_ZNF295	40..151	CDD:349518
		SUF4-like	576..>629	CDD:411020
		C2H2 Zn finger	579..600	CDD:411020
		C2H2 Zn finger	579..600	CDD:275368
		C2H2 Zn finger	608..629	CDD:411020
		zf-C2H2	701..723	CDD:395048	5/24 (21%)
		C2H2 Zn finger	703..723	CDD:275370	5/22 (23%)
		zf_C2H2_6	776..803	CDD:408245	9/36 (25%)
		C2H2 Zn finger	939..959	CDD:275370	7/26 (27%)
		C2H2 Zn finger	967..988	CDD:275370	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24408
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100