DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PCB and PYC1

DIOPT Version :9

Sequence 1:	NP_001163103.1	Gene:	PCB / 36020	FlyBaseID:	FBgn0027580	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_011453.1	Gene:	PYC1 / 852818	SGDID:	S000003030	Length:	1178	Species:	Saccharomyces cerevisiae

Alignment Length:	1162	Identity:	628/1162 - (54%)
Similarity:	834/1162 - (71%)	Gaps:	20/1162 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 VLVANRGEIAIRVFRACTELGIKSVAVYSEQDKMHMHRQKADESYIVGK--GLPPVEAYLNIPEL 104
            :||||||||.||:||...||.:::||:||.:|::..|:|||||:|::|:  ...||.|||.|.|:
Yeast    22 ILVANRGEIPIRIFRTAHELSMQTVAIYSHEDRLSTHKQKADEAYVIGEVGQYTPVGAYLAIDEI 86

  Fly   105 IRVCKENDVDAVHPGYGFLSERSDFAQAVIDAGLRFIGPSPEVVQKMGDKVAARVAAIEAGVPIV 169
            |.:.:::.||.:|||||||||.|:||..|:.||:.:|||..||:..:||||:||..|.:|.||.|
Yeast    87 ISIAQKHQVDFIHPGYGFLSENSEFADKVVKAGITWIGPPAEVIDSVGDKVSARNLAAKANVPTV 151

  Fly   170 PGTDGPVTTKEEALEFCKKHGLPVIFKAAYGGGGRGMRVVRKMEDVEESFQRASSEAKAAFGNGA 234
            |||.||:.|.||||:|..::|.|||.|||:|||||||||||:.:||.::||||:|||:.|||||.
Yeast   152 PGTPGPIETVEEALDFVNEYGYPVIIKAAFGGGGRGMRVVREGDDVADAFQRATSEARTAFGNGT 216

  Fly   235 MFIEKFIERPRHIEVQLLGDKAGNVVHLYERDCSVQRRHQKVVEIAPAPRLPIEIRDKMTEAAVR 299
            .|:|:|:::|:|||||||.|..||||||:|||||||||||||||:|||..||.|:||.:...||:
Yeast   217 CFVERFLDKPKHIEVQLLADNHGNVVHLFERDCSVQRRHQKVVEVAPAKTLPREVRDAILTDAVK 281

  Fly   300 LARHVGYENAGTVEFLCDESGNFYFIEVNARLQVEHTVTEEITGIDLVQSQIRVAEGMTLPELGY 364
            ||:..||.||||.|||.|.....||||:|.|:|||||:||||||||:|.:||::|.|.:||:||.
Yeast   282 LAKECGYRNAGTAEFLVDNQNRHYFIEINPRIQVEHTITEEITGIDIVAAQIQIAAGASLPQLGL 346

  Fly   365 TQDKIVPRGYAIQCRVTTEDPANDFQPNTGRLEVFRSGEGMGIRLDSASAYAGAIISPYYDSLLV 429
            .||||..||:|||||:||||||.:|||:|||:||:||..|.|:|||..:||||.||||:|||:||
Yeast   347 FQDKITTRGFAIQCRITTEDPAKNFQPDTGRIEVYRSAGGNGVRLDGGNAYAGTIISPHYDSMLV 411

  Fly   430 KVISHASDLQSSASKMNRALREFRIRGVKTNIPFLLNVLENQKFLHGVLDTYFIDEHPQLFKFKP 494
            |.....|..:....||.|||.|||||||||||||||.:|.|..|:.|...|.|||:.||||:...
Yeast   412 KCSCSGSTYEIVRRKMIRALIEFRIRGVKTNIPFLLTLLTNPVFIEGTYWTTFIDDTPQLFQMVS 476

  Fly   495 SLNRAQKLLNYMGEVLVNGPQTPLATTLKPALVSPHVPEVPLDLSPEAIEREERGEA-KVTE--P 556
            |.|||||||:|:.:|.|||........|.....:|.||.:          .:.:|.. .||:  |
Yeast   477 SQNRAQKLLHYLADVAVNGSSIKGQIGLPKLKSNPSVPHL----------HDAQGNVINVTKSAP 531

  Fly   557 PKGLREVLVCEGPEAFAKEVRNRKELLLMDTTFRDAHQSLLATRVRSHDLLKISPYVTHKFNNLY 621
            |.|.|:||:.:||..||::||.....||||||:|||||||||||||:|||..|:|...|.....:
Yeast   532 PSGWRQVLLEKGPAEFARQVRQFNGTLLMDTTWRDAHQSLLATRVRTHDLATIAPTTAHALAGRF 596

  Fly   622 SLENWGGATFDVALRFLHECPWERLEEMRKRIPNIPFQMLLRGANAVGYTSYPDNVVYKFCELAV 686
            :||.|||||||||:|||||.|||||.::|..:|||||||||||||.|.|:|.|||.:..|.:.|.
Yeast   597 ALECWGGATFDVAMRFLHEDPWERLRKLRSLVPNIPFQMLLRGANGVAYSSLPDNAIDHFVKQAK 661

  Fly   687 QTGMDIFRVFDSLNYLPNLILGMEAAGKAGGVVEAAISYTGDVSDPKRTKYDLKYYTNLADELVK 751
            ..|:|||||||:||.|..|.:|::|..||||||||.:.::||:..|.: ||:|.||..:|:::|:
Yeast   662 DNGVDIFRVFDALNDLEQLKVGVDAVKKAGGVVEATVCFSGDMLQPGK-KYNLDYYLEIAEKIVQ 725

  Fly   752 AGTHVLCIKDMAGLLKPESARLLITAIRDKHPDIPIHIHTHDTSGAGVASMLACANAGADVVDVA 816
            .|||:|.||||||.:||.:|:|||.::|.|:||:|||:||||::|..||||.|||.|||||||||
Yeast   726 MGTHILGIKDMAGTMKPAAAKLLIGSLRAKYPDLPIHVHTHDSAGTAVASMTACALAGADVVDVA 790

  Fly   817 VDSMSGMTSQPSMGAVVASLQGTPLDTNLDLRTVSEYSAYWEQTRTLYAPFECTTTMRSGNADVY 881
            ::||||:|||||:.|::|||:|. :||.:::..|.|..|||.:.|.||:.||  ..::..:.:||
Yeast   791 INSMSGLTSQPSINALLASLEGN-IDTGINVEHVRELDAYWAEMRLLYSCFE--ADLKGPDPEVY 852

  Fly   882 LNEIPGGQYTNLQFQAFSLGLGDFFEDVKKAYREANLLLGDIIKVTPSSKVVGDLAQFMVQNDLT 946
            .:||||||.|||.|||..||||:.:.:.|:||||||.|||||:||||:||||||||||||.|.||
Yeast   853 QHEIPGGQLTNLLFQAQQLGLGEQWAETKRAYREANYLLGDIVKVTPTSKVVGDLAQFMVSNKLT 917

  Fly   947 ADQVLERAEELSFPKSVVEYLQGSIGIPHGGFPEPLRSRVLKDMPR-IEGRPGAELKDLDFDKLK 1010
            :|.|...|..|.||.||:::.:|.||.|:||||||.||.||::..| :..|||.||:..|.:|::
Yeast   918 SDDVRRLANSLDFPDSVMDFFEGLIGQPYGGFPEPFRSDVLRNKRRKLTCRPGLELEPFDLEKIR 982

  Fly  1011 KELQESHTCVTNRDVMSAALYPQVTNDFLNFREKYGPVDKLDTRIFLTGPKVGEEFDVPLERGKT 1075
            ::||.....|...||.|..:||:|..||...||.||.:..|.||.||:..:..||.:|.:|:|||
Yeast   983 EDLQNRFGDVDECDVASYNMYPRVYEDFQKMRETYGDLSVLPTRSFLSPLETDEEIEVVIEQGKT 1047

  Fly  1076 LSVKALAVSADLKPNGIREVFFELNGQLRAVHILDKEAVKEIHVHPKANKSNKSEVGAPMPGTVI 1140
            |.:|..||....|..|.|||:|:|||::|.:.:.|:....|.....||:..:...:||||.|.::
Yeast  1048 LIIKLQAVGDLNKKTGEREVYFDLNGEMRKIRVADRSQKVETVTKSKADMHDPLHIGAPMAGVIV 1112

  Fly  1141 DIRVKVGDKVEKGQPLVVLSAMKMEMVVQSPLAGVVKKLEIANGTKLEGEDLIMIIE 1197
            :::|..|..::||||:.|||||||||::.||..|.||::.:::|..::..||::::|
Yeast  1113 EVKVHKGSLIKKGQPVAVLSAMKMEMIISSPSDGQVKEVFVSDGENVDSSDLLVLLE 1169

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PCB	NP_001163103.1	CPSase_L_chain	39..147	CDD:278706	55/106 (52%)
		pyruv_carbox	41..1197	CDD:130302	627/1160 (54%)
		ATP-grasp_4	153..360	CDD:302634	132/206 (64%)
		Biotin_carb_C	377..484	CDD:214878	65/106 (61%)
		DRE_TIM_PC_TC_5S	584..867	CDD:163675	167/282 (59%)
		PYC_OADA	880..1078	CDD:280576	107/198 (54%)
		biotinyl_domain	1130..1196	CDD:133459	28/65 (43%)
PYC1	NP_011453.1	PycA	14..1170	CDD:223968	628/1162 (54%)
		CPSase_L_chain	20..130	CDD:278706	56/107 (52%)
		CPSase_L_D2	135..329	CDD:280881	127/193 (66%)
		Biotin_carb_C	359..466	CDD:214878	65/106 (61%)
		DRE_TIM_PC_TC_5S	559..840	CDD:163675	167/282 (59%)
		PYC_OADA	851..1050	CDD:280576	107/198 (54%)
		biotinyl_domain	1102..1168	CDD:133459	28/65 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346273
Domainoid	1	1.000	331	1.000	Domainoid score	I171
eggNOG	1	0.900	-	-		E1_COG1038
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5422
Inparanoid	1	1.050	1170	1.000	Inparanoid score	I16
Isobase	1	0.950	-	0	Normalized mean entropy	S286
OMA	1	1.010	-	-		QHG63046
OrthoFinder	1	1.000	-	-		FOG0004118
OrthoInspector	1	1.000	-	-		otm46866
orthoMCL	1	0.900	-	-		OOG6_101725
Panther	1	1.100	-	-	LDO	PTHR43778
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1045
SonicParanoid	1	1.000	-	-		X2859
TreeFam	1	0.960	-	-
	16	15.740