Protein Alignment PCB and DUR12

DIOPT Version :10

• Sequence 1: NP_724841.1
• Gene: PCB / 36020
• FlyBaseID: FBgn0027580
• Length: 1197
• Species: Drosophila melanogaster
• Sequence 2: NP_009767.1
• Gene: DUR12 / 852507
• SGDID: S000000412
• Length: 1835
• Species: Saccharomyces cerevisiae
• Alignment Length: 1393
• Identity: 351/1393 - (25%)
• Similarity: 543/1393 - (38%)
• Gaps: 431/1393 - (30%)

  Fly    41 SVLVANRGEIAIRVFRACTELGIKSVAVYSEQDKMHMHRQKADESYIVGKGLPPVEAYLNIPELI 105
            :||:|||||||:|:.:...:|||:||||||:.||...|...||.| :...|....:.||::.::|
Yeast   635 TVLIANRGEIAVRIIKTLKKLGIRSVAVYSDPDKYSQHVTDADVS-VPLHGTTAAQTYLDMNKII 698

  Fly   106 RVCKENDVDAVHPGYGFLSERSDFAQAVIDAGLRFIGPSPEVVQKMGDKVAARVAAIEAGVPIVP 170
            ...|:.:..|:.||||||||.:||:.|...||:.|:|||.::::.:|.|.:||..|.:||||:||
Yeast   699 DAAKQTNAQAIIPGYGFLSENADFSDACTSAGITFVGPSGDIIRGLGLKHSARQIAQKAGVPLVP 763

  Fly   171 GTDGPVTTKEEALEFCKKHGLPVIFKAAYGGGGRGMRVVRKMEDVEESFQRASSEAKAAFGNGAM 235
            |: ..:|:.|||.:...:...||:.|:..||||.|::.|...||:|..|:....:.:..||:..:
Yeast   764 GS-LLITSVEEAKKVAAELEYPVMVKSTAGGGGIGLQKVDSEEDIEHIFETVKHQGETFFGDAGV 827

  Fly   236 FIEKFIERPRHIEVQLLGDKAGNVVHLYERDCSVQRRHQKVVEIAPAPRLPIEIRDKMTEAAVRL 300
            |:|:|||..||:||||:||..|..:.|.|||||:|||:|||:|..|||.||.:.|..:.:||..|
Yeast   828 FLERFIENARHVEVQLMGDGFGKAIALGERDCSLQRRNQKVIEETPAPNLPEKTRLALRKAAESL 892

  Fly   301 ARHVGYENAGTVEFLCDE-SGNFYFIEVNARLQVEHTVTEEITGIDLVQSQIRVAEGMTLPELGY 364
            ...:.|:.||||||:.|| ...|||:|||.||||||.:||.:||:|||:..||:|.. ..|:...
Yeast   893 GSLLNYKCAGTVEFIYDEKKDEFYFLEVNTRLQVEHPITEMVTGLDLVEWMIRIAAN-DAPDFDS 956

  Fly   365 TQDKIVPRGYAIQCRVTTEDPANDFQPNTGRLEVFRSGEGMGIRLDSASAYAGAIISPYYDSLLV 429
            |  |:...|.:::.|:..|:|..:|:|:.|.|...:..:  ..|:|: ....|..|||.||..|.
Yeast   957 T--KVEVNGVSMEARLYAENPLKNFRPSPGLLVDVKFPD--WARVDT-WVKKGTNISPEYDPTLA 1016

  Fly   430 KVISHASDLQSSASKMNRALREFRIRGVKTNIPFLLNVLENQKFLHGVLDTYFIDEHPQLFKFKP 494
            |:|.|..|...:.||:|:||.|.::.|..|||.:|.:::.:..|....:.|..::.    ::::|
Yeast  1017 KIIVHGKDRDDAISKLNQALEETKVYGCITNIDYLKSIITSDFFAKAKVSTNILNS----YQYEP 1077

  Fly   495 SLNRAQKLLNYMGEVLVNGPQTPLATTLKPALVSPHVPEVPLDLSPEAIEREERGEAKVTEPPKG 559
                                 |.:..||..|..|  :.:.|          ...|..::..||
Yeast  1078 ---------------------TAIEITLPGAHTS--IQDYP----------GRVGYWRIGVPP-- 1107

  Fly   560 LREVLVCEGPEAFAKEVRNRKELLLMDTTFRDAHQSLLATRVRSHDLLKISPYVTHKFNNL-YSL 623
                   .||                    .||:...||.|:..:|....:..||....:: :..
Yeast  1108 -------SGP--------------------MDAYSFRLANRIVGNDYRTPAIEVTLTGPSIVFHC 1145

  Fly   624 ENWGGATFDVALRFL--HECPWERLEEMRKRIPNIPFQMLLRGANAVGYTSYPDNVVYKFCELAV 686
            |.....|...||..|  .|.|..:..|: ||...:....|..|..|.               |.:
Yeast  1146 ETVIAITGGTALCTLDGQEIPQHKPVEV-KRGSTLSIGKLTSGCRAY---------------LGI 1194

  Fly   687 QTGMDIFRVFDSLNYLPNLILGMEAAGKAGGVVEAAISYTGDV----SDPKRTKYDLKYYTNLAD 747
            :.|:|:.:...|.:..        ..|..|| ....:...|||    |:.:....:. ...|:..
Yeast  1195 RGGIDVPKYLGSYSTF--------TLGNVGG-YNGRVLKLGDVLFLPSNEENKSVEC-LPQNIPQ 1249

  Fly   748 EL-------------VKAGTHVLCIKDMAGLLKPESA---------------RLLITAIRDK--- 781
            .|             |..|.|     ......||||.               |..:..|..|
Yeast  1250 SLIPQISETKEWRIGVTCGPH-----GSPDFFKPESIEEFFSEKWKVHYNSNRFGVRLIGPKPKW 1309

  Fly   782 ----------HPDIPIHIHTHDTSGAGVASMLACANAGADVVDVAVDSMSGMTSQPSMGAVVA-- 834
                      ||.     :|||.    |.|:.|....|.:.|.:..|.       ||:|..|.
Yeast  1310 ARSNGGEGGMHPS-----NTHDY----VYSLGAINFTGDEPVIITCDG-------PSLGGFVCQA 1358

  Fly   835 -----------------SLQGTPLDTNLDLRTVSEYSAYWEQTRTLYAPFECTTTMRSGNADVYL 882
                             |:|..||.              :|.:|:|           ..:.||.:
Yeast  1359 VVPEAELWKVGQVKPGDSIQFVPLS--------------YESSRSL-----------KESQDVAI 1398

  Fly   883 NEIPGGQYTNLQFQAFSLGLGDFFEDVKKAYREANLLLGDIIKVTPSSKVVGDLAQFMVQNDLTA 947
            ..:.|.:...|                            |.:.:.||.: ...|||....|:|:.
Yeast  1399 KSLDGTKLRRL----------------------------DSVSILPSFE-TPILAQMEKVNELSP 1434

  Fly   948 DQVLERA-----------EELSFPKS-----------------VVEYLQG--SIGIPHGGFPEPL 982
            ..|..:|           .|::|..|                 :||..||  |:.|...|: :..
Yeast  1435 KVVYRQAGDRYVLVEYGDNEMNFNISYRIECLISLVKKNKTIGIVEMSQGVRSVLIEFDGY-KVT 1498

  Fly   983 RSRVLKDMPRIEGRPGAELKDLDFD----------KLKKELQESHT--CVTNRDVMSAALYPQVT 1035
            :..:||.:...|       .::.||          :|....::|.|  ||........:..|.:.
Yeast  1499 QKELLKVLVAYE-------TEIQFDENWKITSNIIRLPMAFEDSKTLACVQRYQETIRSSAPWLP 1556

  Fly  1036 N--DF------LNFREKYGPVDKL-DTRIFLTGPKVGEEF-----DVPL---------------- 1070
            |  ||      ::..|.|   |.| ..|..:.|  :|:.|     .|||
Yeast  1557 NNVDFIANVNGISRNEVY---DMLYSARFMVLG--LGDVFLGSPCAVPLDPRHRFLGSKYNPSRT 1616

  Fly  1071 --ERGKT-LSVKALAVSADLKPNGIREVFFELNGQLRAVHILDK-------------EAVKEIHV 1119
              |||.. :....:.:.|...|.|     ::|.|  |.:.|.||             ....::..
Yeast  1617 YTERGAVGIGGMYMCIYAANSPGG-----YQLVG--RTIPIWDKLCLAASSEVPWLMNPFDQVEF 1674

  Fly  1120 HP------------------KAN---------------KSNKSEVGAPMPGTVID---------- 1141
            :|                  |.|               .:||..:.|...|.:.:
Yeast  1675 YPVSEEDLDKMTEDCDNGVYKVNIEKSVFDHQEYLRWINANKDSITAFQEGQLGERAEEFAKLIQ 1739

  Fly  1142 ---------IRVK----------------------------VGDKVEKGQPLVVLSAMKMEMVVQ 1169
                     :.||                            |||.:|.||.|:::.|||.||::.
Yeast  1740 NANSELKESVTVKPDEEEDFPEGAEIVYSEYSGRFWKSIASVGDVIEAGQGLLIIEAMKAEMIIS 1804

  Fly  1170 SPLAGVVKKLEIANGTKLEGEDLIMIIE 1197
            :|.:|.:.|:...||..::..|::.:||
Yeast  1805 APKSGKIIKICHGNGDMVDSGDIVAVIE 1832

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PCB	NP_724841.1	PycA	37..1196	CDD:440660	349/1390 (25%)
DUR12	NP_009767.1	allophanate_hyd	49..620	CDD:274265
		urea_carbox	633..1832	CDD:274264	349/1391 (25%)