DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PCB and MCCC1

DIOPT Version :9

Sequence 1:	NP_001163103.1	Gene:	PCB / 36020	FlyBaseID:	FBgn0027580	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_064551.3	Gene:	MCCC1 / 56922	HGNCID:	6936	Length:	725	Species:	Homo sapiens

Alignment Length:	462	Identity:	203/462 - (43%)
Similarity:	291/462 - (62%)	Gaps:	32/462 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 IRSVLVANRGEIAIRVFRACTELGIKSVAVYSEQDKMHMHRQKADESYIVGKGLPPVEAYLNIPE 103
            |..||:|||||||.||.|...:||:::||||||.|:..||...|||:|.:|.. |..::||::.:
Human    49 ITKVLIANRGEIACRVMRTAKKLGVQTVAVYSEADRNSMHVDMADEAYSIGPA-PSQQSYLSMEK 112

  Fly   104 LIRVCKENDVDAVHPGYGFLSERSDFAQAVIDAGLRFIGPSPEVVQKMGDKVAARVAAIEAGVPI 168
            :|:|.|.:...|:|||.|||||..:||:.....|:.||||.|..::.||.|..::.....||||:
Human   113 IIQVAKTSAAQAIHPGCGFLSENMEFAELCKQEGIIFIGPPPSAIRDMGIKSTSKSIMAAAGVPV 177

  Fly   169 VPGTDGPVTTKEEALEFCKKHGLPVIFKAAYGGGGRGMRVVRKMEDVEESFQRASSEAKAAFGNG 233
            |.|..|...:.:...|..::.|.||:.||..||||:|||:||..::.:|..:.|..|||.:|.:.
Human   178 VEGYHGEDQSDQCLKEHARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFNDD 242

  Fly   234 AMFIEKFIERPRHIEVQLLGDKAGNVVHLYERDCSVQRRHQKVVEIAPAPRLPIEIRDKMTEAAV 298
            ||.||||::.|||:|||:.||..||.|:|:||||||||||||::|.||||.:..|:|.|:.||||
Human   243 AMLIEKFVDTPRHVEVQVFGDHHGNAVYLFERDCSVQRRHQKIIEEAPAPGIKSEVRKKLGEAAV 307

  Fly   299 RLARHVGYENAGTVEFLCDESGNFYFIEVNARLQVEHTVTEEITGIDLVQSQIRVAEGMTLPELG 363
            |.|:.|.|..||||||:.|...||.|:|:|.||||||.|||.|||.|||:.|:|:|.|..:|
Human   308 RAAKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPVTEMITGTDLVEWQLRIAAGEKIP--- 369

  Fly   364 YTQDKIVPRGYAIQCRVTTEDPANDFQPNTG--------------RLEVFRSGEGMGIRLDSASA 414
            .:|::|..:|:|.:.|:..|||:|:|.|..|              |:|.       |:|
Human   370 LSQEEITLQGHAFEARIYAEDPSNNFMPVAGPLVHLSTPRADPSTRIET-------GVR------ 421

  Fly   415 YAGAIISPYYDSLLVKVISHASDLQSSASKMNRALREFRIRGVKTNIPFLLNVLENQKFLHGVLD 479
             .|..:|.:||.::.|::..|:|.|::.:|:..:||::.|.|:.|||.||||:..:.:|..|.:.
Human   422 -QGDEVSVHYDPMIAKLVVWAADRQAALTKLRYSLRQYNIVGLHTNIDFLLNLSGHPEFEAGNVH 485

  Fly   480 TYFIDEH 486
            |.||.:|
Human   486 TDFIPQH 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PCB	NP_001163103.1	CPSase_L_chain	39..147	CDD:278706	52/107 (49%)
		pyruv_carbox	41..1197	CDD:130302	202/460 (44%)
		ATP-grasp_4	153..360	CDD:302634	106/206 (51%)
		Biotin_carb_C	377..484	CDD:214878	36/120 (30%)
		DRE_TIM_PC_TC_5S	584..867	CDD:163675
		PYC_OADA	880..1078	CDD:280576
		biotinyl_domain	1130..1196	CDD:133459
MCCC1	NP_064551.3	PccA	49..716	CDD:227111	203/462 (44%)
		CPSase_L_chain	49..157	CDD:278706	52/108 (48%)
		CPSase_L_D2	163..369	CDD:280881	106/205 (52%)
		Biotin_carb_C	383..489	CDD:214878	35/119 (29%)
		biotinyl_domain	651..714	CDD:133459
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D130620at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920