Protein Alignment PCB and PCCA

DIOPT Version :10

• Sequence 1: NP_724841.1
• Gene: PCB / 36020
• FlyBaseID: FBgn0027580
• Length: 1197
• Species: Drosophila melanogaster
• Sequence 2: XP_016876094.1
• Gene: PCCA / 5095
• HGNCID: 8653
• Length: 744
• Species: Homo sapiens
• Alignment Length: 752
• Identity: 271/752 - (36%)
• Similarity: 388/752 - (51%)
• Gaps: 91/752 - (12%)

  Fly     8 SAYRTLRKTQPRVRLNAIFKNGYSSKVEYKP----IRSVLVANRGEIAIRVFRACTELGIKSVAV 68
            :|.|||:......|...:......| |.|.|    ...:|||||||||.||.|.|.::|||:||:
Human    29 AALRTLKHVLYYSRQCLMVSRNLGS-VGYDPNEKTFDKILVANRGEIACRVIRTCKKMGIKTVAI 92

  Fly    69 YSEQDKMHMHRQKADESYIVGKGLPPVEAYLNIPELIRVCKENDVDAVHPGYGFLSERSDFAQAV 133
            :|:.|...:|.:.|||:..||.. |..::|||:..::...|:....|||||||||||..:||:.:
Human    93 HSDVDASSVHVKMADEAVCVGPA-PTSKSYLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARCL 156

  Fly   134 IDAGLRFIGPSPEVVQKMGDKVAARVAAIEAGVPIVPGTDGPVTTKEEALEFCKKHGLPVIFKAA 198
            ....:.||||....:|.||||:.:::.|.:|.|..:||.||.|...|||:...::.|.||:.||:
Human   157 AAEDVVFIGPDTHAIQAMGDKIESKLLAKKAEVNTIPGFDGVVKDAEEAVRIAREIGYPVMIKAS 221

  Fly   199 YGGGGRGMRVVRKMEDVEESFQRASSEAKAAFGNGAMFIEKFIERPRHIEVQLLGDKAGNVVHLY 263
            .||||:|||:....|:..:.|:.:|.||.::||:..:.|||||:.|||||:|:||||.||.:.|.
Human   222 AGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLN 286

  Fly   264 ERDCSVQRRHQKVVEIAPAPRLPIEIRDKMTEAAVRLARHVGYENAGTVEFLCDESGNFYFIEVN 328
            ||:||:|||:|||||.||:..|..|.|..|.|.||.|||.|.|.:|||||||.|...||||:|:|
Human   287 ERECSIQRRNQKVVEEAPSIFLDAETRRAMGEQAVALARAVKYSSAGTVEFLVDSKKNFYFLEMN 351

  Fly   329 ARLQVEHTVTEEITGIDLVQSQIRVAEGMTLPELGYTQDKIVPRGYAIQCRVTTEDPANDF-QPN 392
            .||||||.|||.|||:||||..||||:|.   .|.:.|..|...|:|::|||..|||...| .|:
Human   352 TRLQVEHPVTECITGLDLVQEMIRVAKGY---PLRHKQADIRINGWAVECRVYAEDPYKSFGLPS 413

  Fly   393 TGRLEVFRSGEGM-GIRLDSASAYAGAIISPYYDSLLVKVISHASDLQSSASKMNRALREFRIRG 456
            .|||..::....: |:|:|| ....|:.||.|||.::.|:|::.||...:..:|..||..:.|||
Human   414 IGRLSQYQEPLHLPGVRVDS-GIQPGSDISIYYDPMISKLITYGSDRTEALKRMADALDNYVIRG 477

  Fly   457 VKTNIPFLLNVLENQKFLHGVLDTYFI-DEHPQLFKFKPSLNRAQKLLNYMGEVLVNGPQTPL-- 518
            |..||..|..|:.|.:|:.|.:.|.|: |.:|..||               |.:|....:..|
Human   478 VTHNIALLREVIINSRFVKGDISTKFLSDVYPDGFK---------------GHMLTKSEKNQLLA 527

  Fly   519 -ATTLKPA--LVSPHVPE---VPLDLSPEAIEREERGEAKVTEPPKGLREVLVCEGPEAFAKEVR 577
             |::|..|  |.:.|..|   :|: :.|:.    ...|..|....| :..|:.......|:.||.
Human   528 IASSLFVAFQLRAQHFQENSRMPV-IKPDI----ANWELSVKLHDK-VHTVVASNNGSVFSVEVD 586

  Fly   578 NRK-----------ELL--LMDTTFRDAHQSL-LATRVRSHDLLKISPYVTHKFNN---LYSLEN 625
            ..|           .||  .:|.|.|...:.| :..|..||   .:.|.::|....   .:|...
Human   587 GSKLNVTSTWNLASPLLSVSVDGTQRTVQEVLQVMCRYNSH---AVGPVLSHSCMARPVSFSRSR 648

  Fly   626 WGGATFDVALRFLHECPW----------ERLEEMRKRIPNIPFQMLLRGANAVGYTSYPDNV--- 677
            |         :..|...|          :..:...|.:..|.:.|:......:|.  :|..:
Human   649 W---------KHEHSVSWYSGARGSGKVQHCQLSTKSVSVIKYPMVCGSGTEMGL--FPKALSMA 702

  Fly   678 --VYKFCELAVQTGMDIFRVFDSLNYLPNLILGMEAA 712
              || ||.|:....:....|  |..|..:|::.:|.|
Human   703 TSVY-FCILSCIASVAYILV--STVYGESLLIEIETA 736

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PCB	NP_724841.1	PycA	37..1196	CDD:440660	263/723 (36%)
PCCA	XP_016876094.1	PccA	63..512	CDD:443802	210/453 (46%)
		PCC_BT	525..>615	CDD:465666	22/95 (23%)