DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PCB and pcca

DIOPT Version :9

Sequence 1:	NP_001163103.1	Gene:	PCB / 36020	FlyBaseID:	FBgn0027580	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_001002746.1	Gene:	pcca / 437019	ZFINID:	ZDB-GENE-040718-246	Length:	709	Species:	Danio rerio

Alignment Length:	714	Identity:	252/714 - (35%)
Similarity:	375/714 - (52%)	Gaps:	72/714 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SAYRTLRKTQPRVRLNAI----FKN-------GYSSKVE--YKPIRSVLVANRGEIAIRVFRACT 59
            :|||:....| || |:|:    ||.       .||:.:|  .|....:|:|||||||.||.:.|.
Zfish     2 AAYRSAAGFQ-RV-LHAVKHVCFKQRCGVIICRYSTVIEPNDKTFDKILIANRGEIACRVIKTCR 64

  Fly    60 ELGIKSVAVYSEQDKMHMHRQKADESYIVGKGLPPVEAYLNIPELIRVCKENDVDAVHPGYGFLS 124
            ::|||:|||:|:.|...:|.:.|||:..||.. |..::|||:..::...|.....||||||||||
Zfish    65 KMGIKTVAVHSDVDSSAVHVKMADEAVCVGPA-PTSKSYLNMDAIMNAIKLTGAQAVHPGYGFLS 128

  Fly   125 ERSDFAQAVIDAGLRFIGPSPEVVQKMGDKVAARVAAIEAGVPIVPGTDGPVTTKEEALEFCKKH 189
            |..:||:.:...|:.||||....:|.||||:.:::.|..|.|..:||.||.|...|||::...:.
Zfish   129 ENKEFAKRLAAEGVTFIGPDTHAIQAMGDKIESKLIAKAAKVNTIPGFDGVVKDAEEAVKIAGEI 193

  Fly   190 GLPVIFKAAYGGGGRGMRVVRKMEDVEESFQRASSEAKAAFGNGAMFIEKFIERPRHIEVQLLGD 254
            |.||:.||:.||||:|||:....|:..|.|:.:|.||.::||:..:.|||||:.|||||:|:|.|
Zfish   194 GYPVMIKASAGGGGKGMRIAWNDEETREGFRFSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLAD 258

  Fly   255 KAGNVVHLYERDCSVQRRHQKVVEIAPAPRLPIEIRDKMTEAAVRLARHVGYENAGTVEFLCDES 319
            |.||.:.|.||:||:|||:|||||.||:..|..:.|.||.|.||.||:.|.|.:|||||||.|..
Zfish   259 KHGNALWLNERECSIQRRNQKVVEEAPSTFLDPDTRRKMGEQAVSLAKAVKYSSAGTVEFLVDSK 323

  Fly   320 GNFYFIEVNARLQVEHTVTEEITGIDLVQSQIRVAEGMTLPELGYTQDKIVPRGYAIQCRVTTED 384
            .||||:|:|.||||||.:||.|||:|||:..||:|:|   .:|.:.|..|...|:||:.||..||
Zfish   324 KNFYFLEMNTRLQVEHPITECITGLDLVEQMIRIAKG---NKLQHKQSDIPINGWAIESRVYAED 385

  Fly   385 PANDF-QPNTGRLEVFRSGEGM-GIRLDSASAYAGAIISPYYDSLLVKVISHASDLQSSASKMNR 447
            |...| .|:.|||..::....: .:|:|| ....|:.||.|||.::.|::::....:.:..||..
Zfish   386 PYKSFGLPSIGRLSQYQEPLDLDNVRVDS-GIQEGSDISIYYDPMISKLVTYGKTREEALKKMEE 449

  Fly   448 ALREFRIRGVKTNIPFLLNVLENQKFLHGVLDTYFIDE-HPQLFKFKPSLNRAQKLLNYMGEVLV 511
            ||..:.:|||..|||.|..::.:.:|:.|.:.|.|:.| :|..||               |.:|.
Zfish   450 ALDNYVVRGVTHNIPLLREIIVHPRFVSGDISTKFLPEVYPDGFK---------------GHMLT 499

  Fly   512 NGPQTPLATTLKPALVSPHVPEVPL--DLSPEAIEREERGEAKVTEPPKGLREVLVCEGPEAFAK 574
            .|.:..|..|......:..:.....  ||....:..|........|..|.:..:.|......:..
Zfish   500 AGERQELLATAAALYTAAQLRSQRFLGDLRVSCVPAESSDWELCVELEKSVHMLGVSRSGNKYTV 564

  Fly   575 EVRNRKELL---------LMDTTFRDAHQSL-LATRVRSHDLLKISPYVTHKFNNLYSLENWGGA 629
            |:...|..:         |:..|....|::| ..:|..:.::  |..|:              |.
Zfish   565 EIDGEKVQVSGEWNLASALLSVTINGKHRTLQCLSRTAAGEI--ILQYL--------------GT 613

  Fly   630 TFDVALRFLHECPWERLEEMRKRIPNIPFQMLLRG---ANAVGYTSYPDNVVYKFCELAVQTGM 690
            :|  .||.|.:......:.|.:::|. ....:||.   .:.|..:..|.:.|.:..|:.|...|
Zfish   614 SF--KLRVLSKLAASLSKHMPEKVPE-DTSSILRSPMPGSVVAVSVKPGDTVAEGQEICVIEAM 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PCB	NP_001163103.1	CPSase_L_chain	39..147	CDD:278706	48/107 (45%)
		pyruv_carbox	41..1197	CDD:130302	238/668 (36%)
		ATP-grasp_4	153..360	CDD:302634	107/206 (52%)
		Biotin_carb_C	377..484	CDD:214878	35/108 (32%)
		DRE_TIM_PC_TC_5S	584..867	CDD:163675	22/111 (20%)
		PYC_OADA	880..1078	CDD:280576
		biotinyl_domain	1130..1196	CDD:133459
pcca	NP_001002746.1	PccA	44..709	CDD:227111	238/670 (36%)
		CPSase_L_chain	44..152	CDD:278706	48/108 (44%)
		CPSase_L_D2	157..363	CDD:280881	107/208 (51%)
		Biotin_carb_C	378..485	CDD:214878	34/107 (32%)
		biotinyl_domain	643..708	CDD:133459	8/32 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D130620at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920