DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PCB and Pc

DIOPT Version :9

Sequence 1:	NP_001163103.1	Gene:	PCB / 36020	FlyBaseID:	FBgn0027580	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	XP_006230753.1	Gene:	Pc / 25104	RGDID:	3262	Length:	1179	Species:	Rattus norvegicus

Alignment Length:	1181	Identity:	798/1181 - (67%)
Similarity:	967/1181 - (81%)	Gaps:	30/1181 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 PRVRLNAIFKNGYSSKVEYKPIRSVLVANRGEIAIRVFRACTELGIKSVAVYSEQDKMHMHRQKA 82
            |.||           ::|||||:.|:||||||||||||||||||||::||||||||...||||||
  Rat    28 PNVR-----------RLEYKPIKKVMVANRGEIAIRVFRACTELGIRTVAVYSEQDTGQMHRQKA 81

  Fly    83 DESYIVGKGLPPVEAYLNIPELIRVCKENDVDAVHPGYGFLSERSDFAQAVIDAGLRFIGPSPEV 147
            ||:|::|:||.||:|||:||::|:|.|||.||||||||||||||:|||||..|||:|||||||||
  Rat    82 DEAYLIGRGLAPVQAYLHIPDIIKVAKENGVDAVHPGYGFLSERADFAQACQDAGVRFIGPSPEV 146

  Fly   148 VQKMGDKVAARVAAIEAGVPIVPGTDGPVTTKEEALEFCKKHGLPVIFKAAYGGGGRGMRVVRKM 212
            |:||||||.||..||.||||:||||:.|:.:..||.||...:|.|:||||||||||||||||...
  Rat   147 VRKMGDKVEARAIAIAAGVPVVPGTNSPINSLHEAHEFSNTYGFPIIFKAAYGGGGRGMRVVHSY 211

  Fly   213 EDVEESFQRASSEAKAAFGNGAMFIEKFIERPRHIEVQLLGDKAGNVVHLYERDCSVQRRHQKVV 277
            |::||::.||.|||.|||||||:|:|||||:|||||||:|||:.||::||||||||:||||||||
  Rat   212 EELEENYTRAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDQYGNILHLYERDCSIQRRHQKVV 276

  Fly   278 EIAPAPRLPIEIRDKMTEAAVRLARHVGYENAGTVEFLCDESGNFYFIEVNARLQVEHTVTEEIT 342
            |||||..|..::|.::|..:|:||:.||||||||||||.|:.|..||||||:|||||||||||||
  Rat   277 EIAPATHLDPQLRSRLTSDSVKLAKQVGYENAGTVEFLVDKHGKHYFIEVNSRLQVEHTVTEEIT 341

  Fly   343 GIDLVQSQIRVAEGMTLPELGYTQDKIVPRGYAIQCRVTTEDPANDFQPNTGRLEVFRSGEGMGI 407
            .:|||.:||.|:||.:||:||..|:.|...|.||||||||||||..|||:|||:|||||||||||
  Rat   342 DVDLVHAQIHVSEGRSLPDLGLRQENIRINGCAIQCRVTTEDPARSFQPDTGRIEVFRSGEGMGI 406

  Fly   408 RLDSASAYAGAIISPYYDSLLVKVISHASDLQSSASKMNRALREFRIRGVKTNIPFLLNVLENQK 472
            |||:|||:.||:|||:|||||||||:|..|..::|:||:|||.|||:||||||||||.|||.||:
  Rat   407 RLDNASAFQGAVISPHYDSLLVKVIAHGKDHPTAATKMSRALAEFRVRGVKTNIPFLQNVLNNQQ 471

  Fly   473 FLHGVLDTYFIDEHPQLFKFKPSLNRAQKLLNYMGEVLVNGPQTPLATTLKPALVSPHVPEVPLD 537
            ||.|::||.||||:|:||:.:|:.|||||||:|:|.|:||||.||:...:.|:.|.|.||.||
  Rat   472 FLAGIVDTQFIDENPELFQLRPAQNRAQKLLHYLGHVMVNGPTTPIPVKVSPSPVDPIVPVVP-- 534

  Fly   538 LSPEAIEREERGEAKVTEPPKGLREVLVCEGPEAFAKEVRNRKELLLMDTTFRDAHQSLLATRVR 602
                           :..||.|.|::|:.||||.||:.|||.:.|||||||||||||||||||||
  Rat   535 ---------------IGPPPAGFRDILLREGPEGFARAVRNHQGLLLMDTTFRDAHQSLLATRVR 584

  Fly   603 SHDLLKISPYVTHKFNNLYSLENWGGATFDVALRFLHECPWERLEEMRKRIPNIPFQMLLRGANA 667
            :|||.||:|||.|.||||:|:|||||||||||:|||:||||.||:|:|:.|||||||||||||||
  Rat   585 THDLKKIAPYVAHNFNNLFSIENWGGATFDVAMRFLYECPWRRLQELRELIPNIPFQMLLRGANA 649

  Fly   668 VGYTSYPDNVVYKFCELAVQTGMDIFRVFDSLNYLPNLILGMEAAGKAGGVVEAAISYTGDVSDP 732
            ||||:||||||:||||:|.:.|||:||:|||||||||::|||||||.|||||||||||||||:||
  Rat   650 VGYTNYPDNVVFKFCEVAKENGMDVFRIFDSLNYLPNMLLGMEAAGSAGGVVEAAISYTGDVADP 714

  Fly   733 KRTKYDLKYYTNLADELVKAGTHVLCIKDMAGLLKPESARLLITAIRDKHPDIPIHIHTHDTSGA 797
            .||||.|:||..||:|||:||||:||||||||||||.:..:|::::||:.||:|:|||||||||:
  Rat   715 SRTKYSLEYYMGLAEELVRAGTHILCIKDMAGLLKPAACTMLVSSLRDRFPDLPLHIHTHDTSGS 779

  Fly   798 GVASMLACANAGADVVDVAVDSMSGMTSQPSMGAVVASLQGTPLDTNLDLRTVSEYSAYWEQTRT 862
            |||:|||||.||||||||||||||||||||||||:||..:||||||.:.|..|.:||.|||..|.
  Rat   780 GVAAMLACAQAGADVVDVAVDSMSGMTSQPSMGALVACTKGTPLDTEVPLERVFDYSEYWEGARG 844

  Fly   863 LYAPFECTTTMRSGNADVYLNEIPGGQYTNLQFQAFSLGLGDFFEDVKKAYREANLLLGDIIKVT 927
            |||.|:||.||:|||:|||.|||||||||||.|||.|:|||..|::|||||.|||.:|||:||||
  Rat   845 LYAAFDCTATMKSGNSDVYENEIPGGQYTNLHFQAHSMGLGSKFKEVKKAYVEANQMLGDLIKVT 909

  Fly   928 PSSKVVGDLAQFMVQNDLTADQVLERAEELSFPKSVVEYLQGSIGIPHGGFPEPLRSRVLKDMPR 992
            ||||:|||||||||||.|:..:...:|||||||:||||:|||.|||||||||||.||:||||:||
  Rat   910 PSSKIVGDLAQFMVQNGLSRAEAEAQAEELSFPRSVVEFLQGYIGIPHGGFPEPFRSKVLKDLPR 974

  Fly   993 IEGRPGAELKDLDFDKLKKELQESH-TCVTNRDVMSAALYPQVTNDFLNFREKYGPVDKLDTRIF 1056
            |||||||.|..|:..:|:|:|.:.| ..||..||:|||:||.|...|.:|...:||:|.|:||:|
  Rat   975 IEGRPGASLPPLNLKELEKDLIDRHGEEVTPEDVLSAAMYPDVFAQFKDFTATFGPLDSLNTRLF 1039

  Fly  1057 LTGPKVGEEFDVPLERGKTLSVKALAVSADLKPNGIREVFFELNGQLRAVHILDKEAVKEIHVHP 1121
            |.|||:.|||:|.|||||||.:|||||| ||...|.|:||||||||||::.:.|.:|:||:|.||
  Rat  1040 LQGPKIAEEFEVELERGKTLHIKALAVS-DLNRAGQRQVFFELNGQLRSILVKDTQAMKEMHFHP 1103

  Fly  1122 KANKSNKSEVGAPMPGTVIDIRVKVGDKVEKGQPLVVLSAMKMEMVVQSPLAGVVKKLEIANGTK 1186
            ||.|..|.::||||||.|||::|..|.||.|||||.||||||||.||.||:.|.::|:.:.....
  Rat  1104 KALKDVKGQIGAPMPGKVIDVKVAAGAKVVKGQPLCVLSAMKMETVVTSPMEGTIRKVHVTKDMT 1168

  Fly  1187 LEGEDLIMIIE 1197
            |||:|||:.||
  Rat  1169 LEGDDLILEIE 1179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PCB	NP_001163103.1	CPSase_L_chain	39..147	CDD:278706	83/107 (78%)
		pyruv_carbox	41..1197	CDD:130302	788/1156 (68%)
		ATP-grasp_4	153..360	CDD:302634	139/206 (67%)
		Biotin_carb_C	377..484	CDD:214878	79/106 (75%)
		DRE_TIM_PC_TC_5S	584..867	CDD:163675	217/282 (77%)
		PYC_OADA	880..1078	CDD:280576	132/198 (67%)
		biotinyl_domain	1130..1196	CDD:133459	38/65 (58%)
Pc	XP_006230753.1	PRK12999	34..1179	CDD:237263	793/1162 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353239
Domainoid	1	1.000	453	1.000	Domainoid score	I484
eggNOG	1	0.900	-	-		E1_COG1038
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5422
Inparanoid	1	1.050	1604	1.000	Inparanoid score	I76
OMA	1	1.010	-	-		QHG63046
OrthoDB	1	1.010	-	-		D130620at33208
OrthoFinder	1	1.000	-	-		FOG0004118
OrthoInspector	1	1.000	-	-		oto97765
orthoMCL	1	0.900	-	-		OOG6_101725
Panther	1	1.100	-	-	LDO	PTHR43778
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2859
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770