DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PCB and pcca-1

DIOPT Version :9

Sequence 1:	NP_001163103.1	Gene:	PCB / 36020	FlyBaseID:	FBgn0027580	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_509293.1	Gene:	pcca-1 / 181026	WormBaseID:	WBGene00017864	Length:	724	Species:	Caenorhabditis elegans

Alignment Length:	485	Identity:	203/485 - (41%)
Similarity:	305/485 - (62%)	Gaps:	27/485 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 VLVANRGEIAIRVFRACTELGIKSVAVYSEQDKMHMHRQKADESYIVGKGLPPVEAYLNIPELIR 106
            :|:|||||||.||.:....:|||:|||:|:.|...:|.:.|||:..||:. |..::||....:::
Worm    52 ILIANRGEIACRVIKTARAMGIKTVAVHSDVDSNSLHVKMADEAVCVGEA-PTAKSYLRADRILQ 115

  Fly   107 VCKENDVDAVHPGYGFLSERSDFAQAVIDAGLRFIGPSPEVVQKMGDKVAARVAAIEAGVPIVPG 171
            ..::....|||||||||||.:.||..:..||.:||||:.:.:..||||:.::..|..|.|.::||
Worm   116 AVEDTGAQAVHPGYGFLSENTKFAAELEKAGAKFIGPNSKAILDMGDKIHSKKIATAARVSMIPG 180

  Fly   172 TDGPVTTKEEALEFCKKHGLPVIFKAAYGGGGRGMRVVRKMEDVEESFQRASSEAKAAFGNGAMF 236
            .||.:..::..::..:..|.||:.||:.||||:||||....:...|.::.:..||.::||:..|.
Worm   181 YDGEIADEDMCVKVSRDIGYPVMIKASAGGGGKGMRVAWNDKQAREGYRLSKQEAASSFGDDRML 245

  Fly   237 IEKFIERPRHIEVQLLGDKAGNVVHLYERDCSVQRRHQKVVEIAPAPRLPIEIRDKMTEAAVRLA 301
            :||||:.|||||:|:|.||.||.:.|.||:||:|||:|||:|.||:..:|.|:|.||.|.||:||
Worm   246 VEKFIDNPRHIEMQVLCDKHGNALWLNERECSIQRRNQKVIEEAPSSFVPPEMRRKMGEQAVQLA 310

  Fly   302 RHVGYENAGTVEFLCDESGNFYFIEVNARLQVEHTVTEEITGIDLVQSQIRVAEGMTLPELGYTQ 366
            :.|||::|||||||.|...||||:|:|.||||||.:||.|||||:||..:||:.|..||   .||
Worm   311 KAVGYDSAGTVEFLVDSQRNFYFLEMNTRLQVEHPITECITGIDIVQQMLRVSYGHPLP---ITQ 372

  Fly   367 DKIVPRGYAIQCRVTTEDPANDF-QPNTGRLEVFRSGEGM-GIRLDSASAYAGAIISPYYDSLLV 429
            :::...|:|.:.||..|||...| .|:.|||..:...:.: |:|.|| ....|:.||.|||.|:.
Worm   373 EQVPLNGWAFESRVYAEDPYKGFGLPSVGRLSRYVEPKHVDGVRCDS-GIREGSEISIYYDPLIC 436

  Fly   430 KVISHASDLQSSASKMNRALREFRIRGVKTNIPFLLNVLENQKFLHGVLDTYFIDE-HPQLFK-- 491
            |:::|..:.:.:.::|..||..:.||||..|||.|.::::.::|..|.:.|.::.| :|:.|:
Worm   437 KLVTHGDNREQALNRMQEALDNYVIRGVTHNIPLLRDIVQEKRFRTGDITTKYLPEVYPEGFQGT 501

  Fly   492 ------------FKPSLN-----RAQKLLN 504
                        |..:||     ||.:.||
Worm   502 SLSPKEQDVVIAFASALNARKLARANQFLN 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PCB	NP_001163103.1	CPSase_L_chain	39..147	CDD:278706	46/104 (44%)
		pyruv_carbox	41..1197	CDD:130302	203/485 (42%)
		ATP-grasp_4	153..360	CDD:302634	102/206 (50%)
		Biotin_carb_C	377..484	CDD:214878	37/108 (34%)
		DRE_TIM_PC_TC_5S	584..867	CDD:163675
		PYC_OADA	880..1078	CDD:280576
		biotinyl_domain	1130..1196	CDD:133459
pcca-1	NP_509293.1	PccA	49..724	CDD:227111	203/485 (42%)
		CPSase_L_chain	49..157	CDD:278706	46/105 (44%)
		ATP-grasp_4	162..369	CDD:302634	102/206 (50%)
		Biotin_carb_C	383..490	CDD:214878	37/107 (35%)
		biotinyl_domain	657..723	CDD:133459
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D130620at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920