DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PCB and mccc-1

DIOPT Version :9

Sequence 1:	NP_001163103.1	Gene:	PCB / 36020	FlyBaseID:	FBgn0027580	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_501777.2	Gene:	mccc-1 / 177841	WormBaseID:	WBGene00009319	Length:	671	Species:	Caenorhabditis elegans

Alignment Length:	763	Identity:	260/763 - (34%)
Similarity:	379/763 - (49%)	Gaps:	136/763 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 KPIRSVLVANRGEIAIRVFRACTELGIKSVAVYSEQDKMHMHRQKADESYIVGKGLPPV--EAYL 99
            :||:.|||||||||||||.....::||::|||:|:.|:..:..:|||::|.:|   ||:  |:||
Worm    17 RPIQRVLVANRGEIAIRVQNTARKMGIETVAVFSDADRNSLFVKKADKAYHIG---PPLAAESYL 78

  Fly   100 NIPELIRVCKENDVDAVHPGYGFLSERSDFAQAVIDAGLRFIGPSPEVVQKMGDKVAARVAAIEA 164
            |:.::|.....:...|:|||||||||.:.||:....|||.||||..:.::.||.|..::....:|
Worm    79 NMDKIINSALRSGAQAIHPGYGFLSENAGFAEKCAQAGLVFIGPPAQAIRDMGAKNVSKQIMEDA 143

  Fly   165 GVPIVPGTDG----PVTTKEEALEFCKKHGLPVIFKAAYGGGGRGMRVVRKMEDVEESFQRASSE 225
            .||:|.|..|    ....|:::.|.    |.||:.||.|||||:|||:.....:.||....|.:|
Worm   144 KVPVVKGFHGEDQSDANLKKKSAEI----GYPVMLKAVYGGGGKGMRIAWNEAEFEEKLASARNE 204

  Fly   226 AKAAFGNGAMFIEKFIERPRHIEVQLLGDKAGNVVHLYERDCSVQRRHQKVVEIAPAPRLPIEIR 290
            ||.:|||..|.:|||:|:|||:|||:.||..||.|||:||||||||||||::|.||||.:..:.|
Worm   205 AKKSFGNDEMLVEKFVEKPRHVEVQVFGDHHGNYVHLWERDCSVQRRHQKIIEEAPAPNMEHDTR 269

  Fly   291 DKMTEAAVRLARHVGYENAGTVEFLCDESGNFYFIEVNARLQVEHTVTEEITGIDLVQSQIRVAE 355
            .|:.|:|||.|..|||..||||||:.|..|.|||:|:|.||||||.|:|.|||.|||:.|:|||:
Worm   270 VKLGESAVRAAAAVGYVGAGTVEFIMDPRGEFYFMEMNTRLQVEHPVSEAITGTDLVEWQLRVAQ 334

  Fly   356 GMTLPELGYTQDKIVPRGYAIQCRVTTEDPAND-FQPNTGRLEVFRSGEGMGIRLDSASAYAGAI 419
            |..||   ..|.:|...|:|.:|||..||.... |.|..|||......|  ..|:|: ...:|..
Worm   335 GEKLP---LKQSEIPLNGHAFECRVYAEDTRKGAFMPTAGRLNYVDFPE--DARIDT-GVVSGDE 393

  Fly   420 ISPYYDSLLVKVISHASDLQSSASKMNRALREFRIRGVKTNIPFLLNVLENQKFLHGVLDTYFID 484
            :|.:||.::.||:....|...:|:|:..||...||.|:.|||.|:..||.:.:|..|.:.|.||.
Worm   394 VSIHYDPMIAKVVVWGQDRAVAAAKLESALARTRISGLPTNIDFVRRVLAHPEFAAGNVYTDFIP 458

  Fly   485 EHPQLFKFKPSLNRAQKLLNYMGEVLVNGPQTPLATTLKPALVSPHVPEVPLDLSPEAIEREERG 549
            :|             ||.|....|       ||....::.|:.             .|:...::.
Worm   459 DH-------------QKELFAESE-------TPAEIYVESAVA-------------HALAALQKS 490

  Fly   550 EAKVTE---------PPKGLREVLVCEGPEAFAKEVRNRKELLLMDTTFRDAHQSLLATRVRSHD 605
            :|.|.:         .||.:.::   :|                .|.:.|....|.|.
Worm   491 DAGVFQNLSFFRMNLSPKYIFKI---DG----------------KDVSIRFDSDSRLT------- 529

  Fly   606 LLKISPYVTHKFNNLYSLENWGGATFDVALRFLHECPWERLEEMRKRIPNIPFQMLLRGANAVGY 670
                   |::..|:..:|.|...:|.|.:.:|..|....|...:.|.:.|    .|:  .|.||.
Worm   530 -------VSYDGNSYETLLNDIESTTDGSFKFTLEANGRRWSTVVKNLGN----SLM--VNGVGQ 581

  Fly   671 TSYPDNVVYKFCELAVQTGMDIFRVFDSLNYLPNLILGMEAAGKA----GGVVEAAISYTGDVSD 731
            ..|....:::              .||||:       |..|:..|    .|::|..:...|:...
Worm   582 NEYETPQIHE--------------TFDSLS-------GGAASHSAVAPMPGIIEKILVKPGEQVT 625

  Fly   732 PKR-----TKYDLKYYTNLADELVKAGTHVLCIKDMAGLLKPESARLL 774
            ..:     |...::|.....::  ....|:.|   .||...|::|.|:
Worm   626 TGQALVVMTAMKMEYIIRAPED--STVEHIKC---QAGKNVPKNAVLV 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PCB	NP_001163103.1	CPSase_L_chain	39..147	CDD:278706	52/109 (48%)
		pyruv_carbox	41..1197	CDD:130302	258/759 (34%)
		ATP-grasp_4	153..360	CDD:302634	108/210 (51%)
		Biotin_carb_C	377..484	CDD:214878	37/107 (35%)
		DRE_TIM_PC_TC_5S	584..867	CDD:163675	39/200 (20%)
		PYC_OADA	880..1078	CDD:280576
		biotinyl_domain	1130..1196	CDD:133459
mccc-1	NP_501777.2	PccA	19..671	CDD:227111	259/761 (34%)
		CPSase_L_chain	19..127	CDD:278706	52/110 (47%)
		ATP-grasp_4	133..339	CDD:302634	108/209 (52%)
		Biotin_carb_C	353..457	CDD:280880	36/106 (34%)
		biotinyl_domain	606..670	CDD:133459	12/68 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D130620at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920