DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PCB and pcca

DIOPT Version :9

Sequence 1:	NP_001163103.1	Gene:	PCB / 36020	FlyBaseID:	FBgn0027580	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	XP_002937132.1	Gene:	pcca / 100493552	XenbaseID:	XB-GENE-944987	Length:	710	Species:	Xenopus tropicalis

Alignment Length:	471	Identity:	208/471 - (44%)
Similarity:	294/471 - (62%)	Gaps:	16/471 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 SKVEY--------KPIRSVLVANRGEIAIRVFRACTELGIKSVAVYSEQDKMHMHRQKADESYIV 88
            |.|:|        |....:|:|||||||.||.:.|.::|||:|||:|:.|...:|.:.|||:..|
Frog    30 SFVQYSTAHDPNEKTFDKILIANRGEIACRVIKTCRKMGIKTVAVHSDVDSASVHVKMADEAVCV 94

  Fly    89 GKGLPPVEAYLNIPELIRVCKENDVDAVHPGYGFLSERSDFAQAVIDAGLRFIGPSPEVVQKMGD 153
            |.. |..::|||:..::...|.....|||||||||||..:||:.:....:.||||....:|.|||
Frog    95 GPA-PTSKSYLNMDAIMDAIKHTGAQAVHPGYGFLSENKEFARRLAAESVTFIGPDTHAIQAMGD 158

  Fly   154 KVAARVAAIEAGVPIVPGTDGPVTTKEEALEFCKKHGLPVIFKAAYGGGGRGMRVVRKMEDVEES 218
            |:.:::.|..|.|..:||.||.|...:||:...::.|.||:.||:.||||:|||:....|:..|.
Frog   159 KIESKLLAKNAKVNTIPGFDGVVKDADEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETREG 223

  Fly   219 FQRASSEAKAAFGNGAMFIEKFIERPRHIEVQLLGDKAGNVVHLYERDCSVQRRHQKVVEIAPAP 283
            |:.::.||.::||:..:.|||||:.|||||:|:|.||.||.:.|.||:||:|||:|||||.||:.
Frog   224 FRFSAQEAASSFGDDRLLIEKFIDNPRHIEIQVLADKHGNALWLNERECSIQRRNQKVVEEAPST 288

  Fly   284 RLPIEIRDKMTEAAVRLARHVGYENAGTVEFLCDESGNFYFIEVNARLQVEHTVTEEITGIDLVQ 348
            .|..|.|..|.|.||.||:.|.|.:|||||||.|...||:|:|:|.||||||.:||.|||:||||
Frog   289 FLDPETRRAMGEQAVALAKAVKYSSAGTVEFLVDSKKNFFFLEMNTRLQVEHPITECITGLDLVQ 353

  Fly   349 SQIRVAEGMTLPELGYTQDKIVPRGYAIQCRVTTEDPANDF-QPNTGRLEVFRSGEGM-GIRLDS 411
            ..||||:|.:|.   :.|..|...|:||:|||..|||...| .|:.|||..::....: |:|:||
Frog   354 EMIRVAKGYSLK---HKQADISINGWAIECRVYAEDPYKSFGLPSIGRLSQYQEPHLLPGVRVDS 415

  Fly   412 ASAYAGAIISPYYDSLLVKVISHASDLQSSASKMNRALREFRIRGVKTNIPFLLNVLENQKFLHG 476
             ....|:.||.:||.::.|:::|..|...:..:|..||..:.||||..|||.|..::.:..|:.|
Frog   416 -GIQEGSDISIFYDPMISKLVTHGRDRTEALKRMEDALDNYVIRGVTHNIPLLHEIITHPLFVKG 479

  Fly   477 VLDTYFIDE-HPQLFK 491
            .:.|.|:.| :|..||
Frog   480 DITTKFLPEVYPDGFK 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PCB	NP_001163103.1	CPSase_L_chain	39..147	CDD:278706	47/107 (44%)
		pyruv_carbox	41..1197	CDD:130302	204/454 (45%)
		ATP-grasp_4	153..360	CDD:302634	106/206 (51%)
		Biotin_carb_C	377..484	CDD:214878	38/108 (35%)
		DRE_TIM_PC_TC_5S	584..867	CDD:163675
		PYC_OADA	880..1078	CDD:280576
		biotinyl_domain	1130..1196	CDD:133459
pcca	XP_002937132.1	PccA	45..710	CDD:227111	204/456 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D130620at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010