Protein Alignment PCB and pc.2

DIOPT Version :9

• Sequence 1: NP_001163103.1
• Gene: PCB / 36020
• FlyBaseID: FBgn0027580
• Length: 1197
• Species: Drosophila melanogaster
• Sequence 2: XP_012817689.1
• Gene: pc.2 / 100125118
• XenbaseID: XB-GENE-5762327
• Length: 1177
• Species: Xenopus tropicalis
• Alignment Length: 1176
• Identity: 817/1176 - (69%)
• Similarity: 977/1176 - (83%)
• Gaps: 20/1176 - (1%)

  Fly    22 LNAIFKNGYSSKVEYKPIRSVLVANRGEIAIRVFRACTELGIKSVAVYSEQDKMHMHRQKADESY 86
            |||.|::  :.:|:||||:.||||||||||.|||||||||||::||||||||...||||||||:|
 Frog    22 LNAAFQS--TQRVDYKPIKKVLVANRGEIATRVFRACTELGIRTVAVYSEQDTGQMHRQKADEAY 84

  Fly    87 IVGKGLPPVEAYLNIPELIRVCKENDVDAVHPGYGFLSERSDFAQAVIDAGLRFIGPSPEVVQKM 151
            |:|||||||:||||||::|:|.|||:||||||||||||||||||||..|||:||||||||||:||
 Frog    85 IIGKGLPPVQAYLNIPDIIKVAKENEVDAVHPGYGFLSERSDFAQACTDAGVRFIGPSPEVVRKM 149

  Fly   152 GDKVAARVAAIEAGVPIVPGTDGPVTTKEEALEFCKKHGLPVIFKAAYGGGGRGMRVVRKMEDVE 216
            ||||.||..||.||||:|||||.|::...||.||..|:|.|:|||||||||||||||||..|::|
 Frog   150 GDKVEARAIAISAGVPVVPGTDSPISCLTEAKEFSNKYGFPIIFKAAYGGGGRGMRVVRSYEELE 214

  Fly   217 ESFQRASSEAKAAFGNGAMFIEKFIERPRHIEVQLLGDKAGNVVHLYERDCSVQRRHQKVVEIAP 281
            |::.||.|||.:||||||:|:|||||:|||||||:||||.|||:||||||||:||||||||||||
 Frog   215 ENYTRAYSEALSAFGNGALFVEKFIEKPRHIEVQILGDKFGNVIHLYERDCSIQRRHQKVVEIAP 279

  Fly   282 APRLPIEIRDKMTEAAVRLARHVGYENAGTVEFLCDESGNFYFIEVNARLQVEHTVTEEITGIDL 346
            |.:|..::||::|..:|:||:.||||||||||||.|:.|..||||||:|||||||||||||.:||
 Frog   280 AAQLDPQLRDRLTHDSVKLAKQVGYENAGTVEFLVDKHGKHYFIEVNSRLQVEHTVTEEITDVDL 344

  Fly   347 VQSQIRVAEGMTLPELGYTQDKIVPRGYAIQCRVTTEDPANDFQPNTGRLEVFRSGEGMGIRLDS 411
            |.:||.:|||.:|||||..|:.|...|.|||||||||||:..|||:|||:|||||||||||||||
 Frog   345 VHAQIHIAEGKSLPELGLKQENIRINGCAIQCRVTTEDPSRGFQPDTGRIEVFRSGEGMGIRLDS 409

  Fly   412 ASAYAGAIISPYYDSLLVKVISHASDLQSSASKMNRALREFRIRGVKTNIPFLLNVLENQKFLHG 476
            |||:.||:|||:|||||||||:|..|.|.:|:||:|||.||||||||||||||.|||.|.:||||
 Frog   410 ASAFQGAVISPHYDSLLVKVIAHGKDQQVAATKMSRALAEFRIRGVKTNIPFLQNVLNNNQFLHG 474

  Fly   477 VLDTYFIDEHPQLFKFKPSLNRAQKLLNYMGEVLVNGPQTPLATTLKPALVSPHVPEVPLDLSPE 541
            .:||.||||:|.||..||..|||||||:|:|.|:||||.||:....||:.|.|.||.:|::
 Frog   475 TVDTQFIDENPDLFNLKPVQNRAQKLLHYLGHVMVNGPTTPIPVKAKPSSVDPVVPPIPMN---- 535

  Fly   542 AIEREERGEAKVTEPPKGLREVLVCEGPEAFAKEVRNRKELLLMDTTFRDAHQSLLATRVRSHDL 606
                         :||.|.|::|:.||||.|||.:|..|.|||||||||||||||||||||:|||
 Frog   536 -------------DPPPGFRDILLREGPEGFAKAIRQHKGLLLMDTTFRDAHQSLLATRVRTHDL 587

  Fly   607 LKISPYVTHKFNNLYSLENWGGATFDVALRFLHECPWERLEEMRKRIPNIPFQMLLRGANAVGYT 671
            ..|:|:|:|.||||:|||||||||||||:|||:||||.||:|:|:.|||||||||||||||||||
 Frog   588 KNIAPFVSHNFNNLFSLENWGGATFDVAMRFLYECPWRRLQELRELIPNIPFQMLLRGANAVGYT 652

  Fly   672 SYPDNVVYKFCELAVQTGMDIFRVFDSLNYLPNLILGMEAAGKAGGVVEAAISYTGDVSDPKRTK 736
            :||||.|:||||:|.:.||||||||||||||||:||||||||:|||||||||||||||:||.|||
 Frog   653 NYPDNAVFKFCEVAKENGMDIFRVFDSLNYLPNMILGMEAAGRAGGVVEAAISYTGDVADPTRTK 717

  Fly   737 YDLKYYTNLADELVKAGTHVLCIKDMAGLLKPESARLLITAIRDKHPDIPIHIHTHDTSGAGVAS 801
            |.|.||.|||:||||||||:||||||||||||:|:.:||.|:||:.|:||||:|||||:||||||
 Frog   718 YTLDYYVNLAEELVKAGTHILCIKDMAGLLKPKSSDMLIRALRDRFPNIPIHVHTHDTAGAGVAS 782

  Fly   802 MLACANAGADVVDVAVDSMSGMTSQPSMGAVVASLQGTPLDTNLDLRTVSEYSAYWEQTRTLYAP 866
            |||||:||||:|||||||||||||||||||:||..:||..||.:.|..|.:||.|||..|.||:.
 Frog   783 MLACAHAGADIVDVAVDSMSGMTSQPSMGALVACAKGTDQDTGIQLEKVFDYSEYWEVARGLYSA 847

  Fly   867 FECTTTMRSGNADVYLNEIPGGQYTNLQFQAFSLGLGDFFEDVKKAYREANLLLGDIIKVTPSSK 931
            |:||.||:|||||||.|||||||||||.|||.|:|||:.|::|||||.|||.:|||:||||||||
 Frog   848 FDCTATMKSGNADVYENEIPGGQYTNLHFQAHSMGLGNKFKEVKKAYAEANKILGDVIKVTPSSK 912

  Fly   932 VVGDLAQFMVQNDLTADQVLERAEELSFPKSVVEYLQGSIGIPHGGFPEPLRSRVLKDMPRIEGR 996
            :|||||||||.|.|..:||...|:|||||.|||||:||.:|||:||||||.||:||||:||||||
 Frog   913 IVGDLAQFMVHNGLNREQVETMADELSFPLSVVEYMQGYVGIPYGGFPEPFRSKVLKDLPRIEGR 977

  Fly   997 PGAELKDLDFDKLKKELQESHTCVTNRDVMSAALYPQVTNDFLNFREKYGPVDKLDTRIFLTGPK 1061
            |||.|..:||.||:::|:..:..:|..|:||||:||:|..::.:|..::|||:.|:||:||.|||
 Frog   978 PGASLPSMDFTKLEEKLKSKYDDITPEDIMSAAMYPKVFEEYKDFGSQFGPVECLNTRLFLEGPK 1042

  Fly  1062 VGEEFDVPLERGKTLSVKALAVSADLKPNGIREVFFELNGQLRAVHILDKEAVKEIHVHPKANKS 1126
            :.|||:|.|||||||.:||||: .||...|.||||||||||||:|.:.|.:|:||:|.||||.|.
 Frog  1043 IAEEFEVELERGKTLHIKALAL-GDLNKAGQREVFFELNGQLRSVLVKDTQAMKEMHFHPKALKD 1106

  Fly  1127 NKSEVGAPMPGTVIDIRVKVGDKVEKGQPLVVLSAMKMEMVVQSPLAGVVKKLEIANGTKLEGED 1191
            .|.::||||||.||||:||.|.||||||||.||||||||.:|.||:.|.|||:.:.....|||||
 Frog  1107 VKGQIGAPMPGKVIDIKVKEGTKVEKGQPLCVLSAMKMETLVNSPVTGTVKKVYVKTDMHLEGED 1171

  Fly  1192 LIMIIE 1197
            |::.||
 Frog  1172 LLLEIE 1177

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PCB	NP_001163103.1	CPSase_L_chain	39..147	CDD:278706	88/107 (82%)
		pyruv_carbox	41..1197	CDD:130302	806/1155 (70%)
		ATP-grasp_4	153..360	CDD:302634	144/206 (70%)
		Biotin_carb_C	377..484	CDD:214878	81/106 (76%)
		DRE_TIM_PC_TC_5S	584..867	CDD:163675	220/282 (78%)
		PYC_OADA	880..1078	CDD:280576	128/197 (65%)
		biotinyl_domain	1130..1196	CDD:133459	42/65 (65%)
pc.2	XP_012817689.1	PRK12999	35..1177	CDD:237263	809/1159 (70%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	452	1.000	Domainoid score	I504
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H5422
Inparanoid	1	1.050	1661	1.000	Inparanoid score	I74
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D130620at33208
OrthoFinder	1	1.000	-	-		FOG0004118
OrthoInspector	1	1.000	-	-		oto104450
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2859
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060