DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1671 and UTP13

DIOPT Version :9

Sequence 1:	NP_610526.1	Gene:	CG1671 / 36019	FlyBaseID:	FBgn0033454	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_013323.1	Gene:	UTP13 / 850919	SGDID:	S000004212	Length:	817	Species:	Saccharomyces cerevisiae

Alignment Length:	837	Identity:	205/837 - (24%)
Similarity:	384/837 - (45%)	Gaps:	130/837 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 GSAVNQVDVQTSQIL----NSYGLSSPSADNKRPAELDNIDV--------------EEDTITCFG 85
            |.::|.:...:|.:.    |...|::|..|     |::.||:              :|..||...
Yeast     9 GISLNPIYAGSSAVATVSENGKILATPVLD-----EINIIDLTPGSRKILHKISNEDEQEITALK 68

  Fly    86 LSQ--EHLVTAHRSGLLRLWQLDTGKLVKLWKAQHKGPVIRVEFSPCGRLICTSGGADATLRLWD 148
            |:.  ::|....::.||:::.|.|||:|:..|......::..:.:   ..:...||.|.::.:.|
Yeast    69 LTPDGQYLTYVSQAQLLKIFHLKTGKVVRSMKISSPSYILDADST---STLLAVGGTDGSIIVVD 130

  Fly   149 YSNNSCLGALKDFPGPAWLLVFHPNVLRKEIY---AGGSDNTVYAWNYETKTLVHKMRGHLSQVT 210
            ..|.....:.|...|....|.|: ..|..:|:   :|.::..|..|:...:..:|.::.|.|.|.
Yeast   131 IENGYITHSFKGHGGTISSLKFY-GQLNSKIWLLASGDTNGMVKVWDLVKRKCLHTLQEHTSAVR 194

  Fly   211 GLSF---KSNASDCNEIVTVSRDKVMIVWQLQEQLESKQLKVLPLYDELEGVVYADEG---QLII 269
            ||..   ..|......:::..||.::.:|....:.:.|.||.||:..::|...:..:|   ::|.
Yeast   195 GLDIIEVPDNDEPSLNLLSGGRDDIINLWDFNMKKKCKLLKTLPVNQQVESCGFLKDGDGKRIIY 259

  Fly   270 VASGSGKLQQVDPKSWKIRDILSQSDFQISRLLHCSEL-----KQLALVTTEQNILVYDVE---- 325
            .|.|....|.:|.:|   ..:|.:::..|..|.....|     .|:.||.::|.:.:.:||
Yeast   260 TAGGDAIFQLIDSES---GSVLKRTNKPIEELFIIGVLPILSNSQMFLVLSDQTLQLINVEEDLK 321

  Fly   326 ----TLEPIKHLVGYNDEILDMCFMGEHDRYLAVATNSKHFKLY--------DTEHDMNCKLIVG 378
                |::....:.|.:..|.||.::|.....||:||||...::.        :....::.::..|
Yeast   322 NDEDTIQVTSSIAGNHGIIADMRYVGPELNKLALATNSPSLRIIPVPDLSGPEASLPLDVEIYEG 386

  Fly   379 HSDTVMSLAASQN--LLISVGKDCSVRLWRLQHDKDCSLEALTQQANCHTSTIGCVAMTHNGATG 441
            |.|.:.||.|:::  .:.:..||.:..:|| .::..|..:...:... |::.:..|.:.:..:.|
Yeast   387 HEDLLNSLDATEDGLWIATASKDNTAIVWR-YNENSCKFDIYAKYIG-HSAAVTAVGLPNIVSKG 449

  Fly   442 F----ASVSQDGSMKVW-----------QLVRSKEDRNSYSFNLRYAALSHDKEVNCVAYAPNNK 491
            :    .:.|.|.::|.|           |:::..|          |...:|:|::|.::.:||:.
Yeast   450 YPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSE----------YTRHAHEKDINALSVSPNDS 504

  Fly   492 LIATASQDKTAKVWLAESNTLQGVLRGHTRGVWSVRFSPVDQIVLTSSSDCTLRIWSISNFSCIK 556
            :.||||.|||.|:|..|:..|:..|..|.||:|.|.|...|:::.|||.|.|::|||:..||.:|
Yeast   505 IFATASYDKTCKIWNLENGELEATLANHKRGLWDVSFCQYDKLLATSSGDKTVKIWSLDTFSVMK 569

  Fly   557 RFDQEC-TILRAEFLDHGKFIISAASDGLLKLWNIKTNTCLQSLDEHNDRVWALAVSARSNRFFY 620
            ..:... .:.|..|::..|.:||..:|||:|:|:..:..||::||.||:|:|||: :........
Yeast   570 TLEGHTNAVQRCSFINKQKQLISCGADGLIKIWDCSSGECLKTLDGHNNRLWALS-TMNDGDMIV 633

  Fly   621 TGGADSKLIRFGDVTQVTRNEALDKRQAALEQEQTLHSLLHAQKQLHKAFVLALNLDKPKASFDI 685
            :..||.....:.|.|:....|..:|.:..:||||:|.:.: ::.....||:||:.||.|...|::
Yeast   634 SADADGVFQFWKDCTEQEIEEEQEKAKLQVEQEQSLQNYM-SKGDWTNAFLLAMTLDHPMRLFNV 697

  Fly   686 INHFV-----RKRDEPG---------LRQLVDQLNVDQRVALLQHVKAWTTNSR-HSQAGNMILK 735
            :...:     |:..|.|         |.|.:..||.:|.:.|::..:.|.||:: |:.|...|..
Yeast   698 LKRALGESRSRQDTEEGKIEVIFNEELDQAISILNDEQLILLMKRCRDWNTNAKTHTIAQRTIRC 762

  Fly   736 YLIGDALLDPKARFYYN----------GNMVEVLTPYVQRHFKRVTELNKDLAFLEF 782
            .|:           ::|          ..:|:.:.||.||||.||..|.:....|::
Yeast   763 ILM-----------HHNIAKLSEIPGMVKIVDAIIPYTQRHFTRVDNLVEQSYILDY 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1671	NP_610526.1	WD40 repeat	22..54	CDD:293791	3/18 (17%)
		WD40	64..571	CDD:225201	134/570 (24%)
		WD40 repeat	82..115	CDD:293791	10/34 (29%)
		WD40	118..455	CDD:238121	77/383 (20%)
		WD40 repeat	122..159	CDD:293791	5/36 (14%)
		WD40 repeat	167..206	CDD:293791	8/41 (20%)
		WD40 repeat	209..236	CDD:293791	6/29 (21%)
		WD40 repeat	299..335	CDD:293791	9/48 (19%)
		WD40	329..631	CDD:238121	89/327 (27%)
		WD40 repeat	340..377	CDD:293791	10/44 (23%)
		WD40 repeat	430..476	CDD:293791	9/60 (15%)
		WD40 repeat	481..517	CDD:293791	14/35 (40%)
		WD40 repeat	524..559	CDD:293791	15/34 (44%)
		WD40 repeat	564..600	CDD:293791	12/35 (34%)
		WD40 repeat	608..657	CDD:293791	12/48 (25%)
		Utp13	653..787	CDD:285789	39/155 (25%)
UTP13	NP_013323.1	WD40	<2..177	CDD:225201	37/176 (21%)
		WD40 repeat	19..59	CDD:293791	8/44 (18%)
		WD40 repeat	65..101	CDD:293791	10/35 (29%)
		WD40 repeat	106..141	CDD:293791	5/37 (14%)
		WD40	108..466	CDD:421866	76/366 (21%)
		WD40 repeat	148..187	CDD:293791	8/39 (21%)
		WD40 repeat	196..236	CDD:293791	7/39 (18%)
		WD40 repeat	243..272	CDD:293791	6/28 (21%)
		WD40 repeat	290..330	CDD:293791	8/39 (21%)
		WD40 repeat	340..365	CDD:293791	10/24 (42%)
		WD40	384..648	CDD:238121	79/276 (29%)
		WD40 repeat	392..432	CDD:293791	8/40 (20%)
		WD40 repeat	437..487	CDD:293791	9/59 (15%)
		WD40 repeat	495..530	CDD:293791	14/34 (41%)
		WD40 repeat	536..572	CDD:293791	15/35 (43%)
		WD40 repeat	578..614	CDD:293791	12/35 (34%)
		WD40 repeat	620..644	CDD:293791	5/24 (21%)
		Utp13	666..813	CDD:400791	39/155 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344805
Domainoid	1	1.000	47	1.000	Domainoid score	I3038
eggNOG	1	0.900	-	-		E1_KOG0319
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4711
Inparanoid	1	1.050	258	1.000	Inparanoid score	I637
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53916
OrthoFinder	1	1.000	-	-		FOG0003383
OrthoInspector	1	1.000	-	-		oto99907
orthoMCL	1	0.900	-	-		OOG6_102171
Panther	1	1.100	-	-	LDO	PTHR19854
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1422
SonicParanoid	1	1.000	-	-		X2981
TreeFam	1	0.960	-	-
	15	14.790