DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG1671 and Wdr5b

DIOPT Version :9

Sequence 1:NP_610526.1 Gene:CG1671 / 36019 FlyBaseID:FBgn0033454 Length:787 Species:Drosophila melanogaster
Sequence 2:NP_081389.1 Gene:Wdr5b / 69544 MGIID:1916794 Length:328 Species:Mus musculus


Alignment Length:294 Identity:68/294 - (23%)
Similarity:115/294 - (39%) Gaps:72/294 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   425 HTSTIGCVAMTHNGATGFASVSQDGSMKVWQLVRSKEDRNSYSFNLRYAALSHDKEVNCVAYAPN 489
            |::.|..|..:.|| ...||.:.|..:.:|         .:|..|.:.....|..|::.||::.:
Mouse    38 HSAAISSVKFSPNG-EWLASSAADALIIIW---------GAYDGNCKKTLYGHSLEISDVAWSSD 92

  Fly   490 NKLIATASQDKTAKVWLAESNTLQGVLRGHTRGVWSVRFSPVDQIVLTSSSDCTLRIWSISNFSC 554
            :..:.:||.|||.|||...|......|:||:..|:...|:|...::::.|.|.:::||.:....|
Mouse    93 SSRLVSASDDKTLKVWDMRSGKCLKTLKGHSDFVFCCDFNPPSNLIVSGSFDESVKIWEVKTGKC 157

  Fly   555 IK------------------------RFDQECTILRA--------------------EFLDHGKF 575
            :|                        .:|..|.|..|                    :|..:||:
Mouse   158 LKTLSAHSDPISAVNFNCNGSLIVSGSYDGLCRIWDAASGQCLRTLADEGNPPVSFVKFSPNGKY 222

  Fly   576 IISAASDGLLKLWNIKTNTCLQSLDEHNDRVWAL-----------AVSARSNRFFYTGGADSKLI 629
            |::|..|..||||:.....||::...|.:..:.|           .||...:...|.....:|.|
Mouse   223 ILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCLFASFSVTGRKWVVSGSEDNMVYIWNLQTKEI 287

  Fly   630 --RFGDVTQVTRNEALDKRQ-----AALEQEQTL 656
              |....|.|..:.|....:     ||||.::|:
Mouse   288 VQRLQGHTDVVISAACHPTKNIIASAALENDKTI 321

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1671NP_610526.1 WD40 repeat 22..54 CDD:293791
WD40 64..571 CDD:225201 41/189 (22%)
WD40 repeat 82..115 CDD:293791
WD40 118..455 CDD:238121 8/29 (28%)
WD40 repeat 122..159 CDD:293791
WD40 repeat 167..206 CDD:293791
WD40 repeat 209..236 CDD:293791
WD40 repeat 299..335 CDD:293791
WD40 329..631 CDD:238121 59/262 (23%)
WD40 repeat 340..377 CDD:293791
WD40 repeat 430..476 CDD:293791 9/45 (20%)
WD40 repeat 481..517 CDD:293791 11/35 (31%)
WD40 repeat 524..559 CDD:293791 8/58 (14%)
WD40 repeat 564..600 CDD:293791 14/55 (25%)
WD40 repeat 608..657 CDD:293791 15/67 (22%)
Utp13 653..787 CDD:285789 1/4 (25%)
Wdr5bNP_081389.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..25
WD40 31..325 CDD:238121 68/294 (23%)
WD40 <34..325 CDD:225201 68/294 (23%)
WD 1 37..76 11/47 (23%)
WD40 repeat 42..79 CDD:293791 10/46 (22%)
WD 2 79..120 13/40 (33%)
WD40 repeat 85..121 CDD:293791 12/35 (34%)
WD 3 122..162 10/39 (26%)
WD40 repeat 126..162 CDD:293791 9/35 (26%)
WD 4 163..202 4/38 (11%)
WD40 repeat 169..204 CDD:293791 4/34 (12%)
DDB1-binding motif 186..190 1/3 (33%)
WD 5 206..247 12/40 (30%)
WD40 repeat 211..247 CDD:293791 12/35 (34%)
WD 6 250..290 6/39 (15%)
WD40 repeat 255..292 CDD:293791 7/36 (19%)
WD 7 293..328 8/29 (28%)
WD40 repeat 298..324 CDD:293791 6/24 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1422
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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