DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1671 and tbl3

DIOPT Version :9

Sequence 1:	NP_610526.1	Gene:	CG1671 / 36019	FlyBaseID:	FBgn0033454	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_001017314.1	Gene:	tbl3 / 550068	XenbaseID:	XB-GENE-1012176	Length:	831	Species:	Xenopus tropicalis

Alignment Length:	822	Identity:	267/822 - (32%)
Similarity:	441/822 - (53%)	Gaps:	85/822 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SYAAEARYTNFYAGGDIAWSPNGHHLYCLNGSAVNQVDVQTSQILNSYGLSSPSADNKRPAELDN 73
            :||...:...||.||.:..:.:|.::.|..|:.:|.:|:.|..:  :|.:..
Frog    11 NYAVTRKIEAFYKGGKVQINSDGTYILCTCGNKLNILDIATGAV--TYTIEQ------------- 60

  Fly    74 IDVEEDTITCFGLS--QEHLVTAHRSGLLRLWQLDTGKLVKLWKAQHKGPVIRVEFSPCGRLICT 136
             |.:|| ||.|.||  .|.|||..|:.||:.|....|...:.|||.|..||..:.|.|...|:.|
Frog    61 -DDQED-ITSFALSPDDEILVTGSRALLLKQWDWKQGTCSRTWKAIHTAPVATMTFDPTSTLLAT 123

  Fly   137 SGGADATLRLWDYSNNSCLGALKDFPGPAWLLVFHPNVLRKEIYAGGSDNTVYAWNYETKTLVHK 201
             ||.|:|:::||.....|...||...|...|:.|||::.|.::::...|..:..|:.:|...:..
Frog   124 -GGCDSTIKIWDVIKQYCTHNLKGSSGVVHLVQFHPDMSRLQLFSSSMDYKIRLWDLKTSKCLCV 187

  Fly   202 MRGHLSQVTGLSFKSNASDCNEIVTVSRDKVMIVWQLQEQLESKQLK-VLPLYDELEGVVY---- 261
            |..|.|.||.|.|   :.|.|.:::..|||:..:|    .||:|..| .:|:|:.:|.||.
Frog   188 METHFSAVTSLCF---SPDGNTMISSGRDKICTMW----DLETKSPKRTVPVYESVEAVVLFPDS 245

  Fly   262 -------ADEGQLIIVASGSGKLQQVDPKSWKIRDIL---------------SQSDFQISRLLHC 304
                   .|...|:.:.:||..:.:|    |.....:               ::.:.....|.||
Frog   246 SDIICQENDSQSLLFLTAGSKGILRV----WDAATAVCVYGQTLPHIAEGNSTEEEANEHSLTHC 306

  Fly   305 SEL---KQLALVTTEQNILVYDVETLEPIKHLVGYNDEILDMCFMGEHDRYLAVATNSKHFKLYD 366
            ..:   .|:|.:|.|.|||:||::.|:..|...|||||:||:.|:|..|.::.|||||...|::|
Frog   307 LLIPGQHQVATITAEHNILMYDLQNLQLKKQFAGYNDEVLDVKFLGPSDSHIVVATNSPQLKVFD 371

  Fly   367 TEHDMNCKLIVGHSDTVMSLAASQN--LLISVGKDCSVRLWRLQHDKDCSLEALTQQANCHTSTI 429
            .| ..||:::.||::||::|...:.  |..|..||.::|:||::  |.........|.:.||:.:
Frog   372 LE-TSNCQILYGHTETVLALDVFKKGLLFASCAKDRTIRVWRMK--KATGKVTCVAQGSGHTNGV 433

  Fly   430 GCVAMTHNGATGFASVSQDGSMKVWQLVRSKEDR----NSYSFNLRYAAL---SHDKEVNCVAYA 487
            |.::.:........|.|||.::|:|:|..|..::    ||.......|..   :|||::|.|..:
Frog   434 GTISCSRMKEAFLVSGSQDYTIKLWKLPESLANKQSKGNSGDLETLLACATEKAHDKDINSVTVS 498

  Fly   488 PNNKLIATASQDKTAKVWLAESNTLQGVLRGHTRGVWSVRFSPVDQIVLTSSSDCTLRIWSISNF 552
            ||:||||:.|||||||:|||...:|.||.|||.||:|.|:||.|||::.::|:|.||::|.:.:|
Frog   499 PNDKLIASGSQDKTAKLWLATDLSLLGVFRGHKRGIWCVQFSNVDQVLASTSADGTLKLWGLQDF 563

  Fly   553 SCIKRFD-QECTILRAEFLDHGKFIISAASDGLLKLWNIKTNTCLQSLDEHNDRVWALAVSARSN 616
            ||:|.|: .:.::|:..|:..|..::::.||||||||.||||.|:::||.|.|:||.|..: |.:
Frog   564 SCLKTFEGHDASVLKVVFVSRGAQLLTSGSDGLLKLWTIKTNECVKTLDTHEDKVWGLHCN-RED 627

  Fly   617 RFFYTGGADSKLIRFGDVTQVTRNEALDKRQAALEQEQTLHSLLHAQKQLHKAFVLALNLDKPKA 681
            ....||.|||.:|.:.|||:....|...|...|:.::|.|.:||| :|:..||..||::||:|..
Frog   628 DALVTGSADSAIILWKDVTETELAEEQAKEDEAILKQQELSNLLH-EKRFLKALGLAISLDQPHT 691

  Fly   682 SFDIINHFVRK---RDEPGLRQLVDQLNVDQRVALLQHVKAWTTNSRHSQAGNMILKYLIGDALL 743
            ...::...:::   :|:  |.:.:::|..||:.::|::...|.||||:......:|..::...
Frog   692 VLTVVKAILQEPHGKDD--LEKNIERLRQDQKESILRYCCVWNTNSRNCHEAQSVLSIILTHE-- 752

  Fly   744 DPKARFYYNG--NMVEVLTPYVQRHFKRVTELNKDLAFLEFI 783
            .|::...::|  ..:|.|.||.:||.:|:..|.:...|::|:
Frog   753 PPESLLQFSGIRGSLESLIPYTERHMQRMGRLLQASMFVDFM 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1671	NP_610526.1	WD40 repeat	22..54	CDD:293791	8/31 (26%)
		WD40	64..571	CDD:225201	183/548 (33%)
		WD40 repeat	82..115	CDD:293791	13/34 (38%)
		WD40	118..455	CDD:238121	109/368 (30%)
		WD40 repeat	122..159	CDD:293791	12/36 (33%)
		WD40 repeat	167..206	CDD:293791	9/38 (24%)
		WD40 repeat	209..236	CDD:293791	9/26 (35%)
		WD40 repeat	299..335	CDD:293791	14/38 (37%)
		WD40	329..631	CDD:238121	125/311 (40%)
		WD40 repeat	340..377	CDD:293791	15/36 (42%)
		WD40 repeat	430..476	CDD:293791	12/52 (23%)
		WD40 repeat	481..517	CDD:293791	21/35 (60%)
		WD40 repeat	524..559	CDD:293791	16/34 (47%)
		WD40 repeat	564..600	CDD:293791	16/35 (46%)
		WD40 repeat	608..657	CDD:293791	15/48 (31%)
		Utp13	653..787	CDD:285789	37/136 (27%)
tbl3	NP_001017314.1	WD40	62..569	CDD:225201	179/522 (34%)
		WD40 repeat	66..102	CDD:293791	14/35 (40%)
		WD40	97..459	CDD:238121	112/376 (30%)
		WD40 repeat	109..146	CDD:293791	13/37 (35%)
		WD40 repeat	152..192	CDD:293791	9/39 (23%)
		WD40 repeat	195..230	CDD:293791	14/41 (34%)
		WD40 repeat	237..294	CDD:293791	9/60 (15%)
		WD40	334..643	CDD:238121	125/312 (40%)
		WD40 repeat	345..382	CDD:293791	15/37 (41%)
		WD40 repeat	388..428	CDD:293791	10/41 (24%)
		WD40 repeat	433..486	CDD:293791	12/52 (23%)
		WD40 repeat	493..528	CDD:293791	21/34 (62%)
		WD40 repeat	534..570	CDD:293791	16/35 (46%)
		WD40 repeat	576..612	CDD:293791	16/35 (46%)
		WD40 repeat	618..642	CDD:293791	10/24 (42%)
		Utp13	664..798	CDD:285789	37/136 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I10340
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4711
Inparanoid	1	1.050	431	1.000	Inparanoid score	I1687
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1112002at2759
OrthoFinder	1	1.000	-	-		FOG0003383
OrthoInspector	1	1.000	-	-		oto104442
Panther	1	1.100	-	-	LDO	PTHR19854
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2981
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160