DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1671 and swd3

DIOPT Version :9

Sequence 1:	NP_610526.1	Gene:	CG1671 / 36019	FlyBaseID:	FBgn0033454	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_595227.1	Gene:	swd3 / 2540929	PomBaseID:	SPBC354.03	Length:	380	Species:	Schizosaccharomyces pombe

Alignment Length:	349	Identity:	78/349 - (22%)
Similarity:	152/349 - (43%)	Gaps:	67/349 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   425 HTSTIGCVAMTHNGATGFASVSQDGSMKVWQLVRSKEDRNSYSFNLRYAALSHDKEVNCVAYAPN 489
            |..::.||:::.| ....|:.|.||::|:|         ::.:|.|......|.:.::.|.:|..
pombe    53 HEKSVTCVSVSPN-KRWIATSSSDGTIKIW---------SALTFRLECTLFGHYRGISQVKWATG 107

  Fly   490 NKLIATASQDKTAKVWLAESNTLQGVLRGHTRGVWSVRFSPVDQIVLTSSSDCTLRIWSISNFSC 554
            :|.:|:||.|||.::|..|.......|:|||..|.|:.|:|:..::::.|.|.|:|||::.:.:|
pombe   108 SKYLASASDDKTIRIWDFEKRCSVRCLKGHTNYVSSIDFNPLGTLLVSGSWDETVRIWNLQDGTC 172

  Fly   555 IKRFDQEC-TILRAEFLDHGKFIISAASDGLLKLWNIKTNTCLQSLDE-----------HNDRVW 607
            ::...... .|:.......|....:|:.||:.::|::.:..||::|.|           ..:|.:
pombe   173 LRMLPAHSEPIISVSISADGTLCATASYDGMARIWDVLSGQCLKTLVEPINVPLSNLQFTENRKY 237

  Fly   608 ALAVSARSNRFFYTGGADSKLIRFGDVTQVTR----------------NEALDKRQAALEQEQTL 656
             |.||..:::........::::|..|....||                .|||....::...:
pombe   238 -LLVSNLNSQIRLWDYRRNRVVRIFDSHVNTRYSMSWDCYSSKNIPKNTEALPNNDSSYPDD--- 298

  Fly   657 HSLLHAQKQLHKAFVL------ALNLDKPKASFDIINHFVRKRDEPGLRQLVDQLNVDQRVALL- 714
                 |:..:|.|::|      .:.:..|.... ||:..:|..|:|.    ...|||......:
pombe   299 -----AESFMHDAYLLIPSEDGTIQITDPSTKI-IIDDSIRHSDDPE----TSLLNVTSLGPFII 353

  Fly   715 -----QHVKAWTTN---SRHSQAG 730
                 .:|:.|..:   |:|.:.|
pombe   354 TSGTDPYVRVWAPSLLLSKHEKDG 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1671	NP_610526.1	WD40 repeat	22..54	CDD:293791
		WD40	64..571	CDD:225201	40/146 (27%)
		WD40 repeat	82..115	CDD:293791
		WD40	118..455	CDD:238121	9/29 (31%)
		WD40 repeat	122..159	CDD:293791
		WD40 repeat	167..206	CDD:293791
		WD40 repeat	209..236	CDD:293791
		WD40 repeat	299..335	CDD:293791
		WD40	329..631	CDD:238121	53/217 (24%)
		WD40 repeat	340..377	CDD:293791
		WD40 repeat	430..476	CDD:293791	11/45 (24%)
		WD40 repeat	481..517	CDD:293791	11/35 (31%)
		WD40 repeat	524..559	CDD:293791	10/34 (29%)
		WD40 repeat	564..600	CDD:293791	8/35 (23%)
		WD40 repeat	608..657	CDD:293791	10/64 (16%)
		Utp13	653..787	CDD:285789	18/93 (19%)
swd3	NP_595227.1	WD40	5..379	CDD:225201	78/349 (22%)
		WD40	46..365	CDD:238121	74/335 (22%)
		WD40 repeat	57..94	CDD:293791	11/46 (24%)
		WD40 repeat	100..136	CDD:293791	12/35 (34%)
		WD40 repeat	141..177	CDD:293791	11/35 (31%)
		WD40 repeat	184..219	CDD:293791	7/34 (21%)
		WD40 repeat	226..262	CDD:293791	5/36 (14%)
		WD40 repeat	269..333	CDD:293791	10/72 (14%)
		WD40 repeat	339..364	CDD:293791	4/28 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1422
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030