DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1671 and utp13

DIOPT Version :9

Sequence 1:	NP_610526.1	Gene:	CG1671 / 36019	FlyBaseID:	FBgn0033454	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_587989.2	Gene:	utp13 / 2539337	PomBaseID:	SPCC16A11.02	Length:	777	Species:	Schizosaccharomyces pombe

Alignment Length:	825	Identity:	229/825 - (27%)
Similarity:	408/825 - (49%)	Gaps:	90/825 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LAGISEKS-YAAEARYTNFYAGGDIAWSPNGHHLYCLNGSAVNQVDVQTSQILNSYGLSSPSADN 65
            :|.|.||. :..|......|.||.:|:..|...|          |...|.:|:   |..|.:.:.
pombe     1 MAPIGEKKRFELEKSIEPIYTGGPVAFDSNEKIL----------VTALTDRII---GTRSETGER 52

  Fly    66 KRPAELDNIDVEEDTITCFGLSQE--HLVTAHRSGLLRLWQLDTGKLVKLWKAQHKGPVIRVEFS 128
            ....:.|    |:|.:|...::.:  .|:.|.||.||.::::.:|:.:|..|| |:.|||.:...
pombe    53 LFSIKKD----EDDYVTALAITSDSKKLIAAFRSRLLTIYEIPSGRRIKSMKA-HETPVITMTID 112

  Fly   129 PCGRLICTSGGADATLRLWDYSNNSCLGALKDFPGPAWLLVF--HPNVLRKEIYAGGSDNTVYAW 191
            |...|:.| |||:..:::||.:......:.:...|....|.|  |.|..  .:.:|..|:.|..|
pombe   113 PTNTLLAT-GGAEGLVKVWDIAGAYVTHSFRGHGGVISALCFGKHQNTW--VLASGADDSRVRLW 174

  Fly   192 NYETKTLVHKMRGHLSQVTGLSFKSNASDCNEIVTVSRDKVMIVWQLQEQLESKQLKVLPLYDEL 256
            :..:...:....||.|.:.||:|:...|   .:::.||||.:.||.::::   ..::.:|::..:
pombe   175 DLNSSRSMAVFEGHSSVIRGLTFEPTGS---FLLSGSRDKTVQVWNIKKR---SAVRTIPVFHSV 233

  Fly   257 EGVVY------------ADEGQLIIV---ASGSGKLQQVDPKSWKIRDILSQSDFQISRLLHCSE 306
            |.:.:            |.||.||:.   .|||.....||....:...|:....|..:.||  |.
pombe   234 EAIGWVNGQPEEKILYTAGEGNLILAWDWKSGSRLDPGVDTTHSETNAIIQVVPFSENTLL--SV 296

  Fly   307 LKQLALVTTEQNILVYDVETLEPIKHLVGYNDEILDMCFMGEHDRYLAVATNSKHFKLYDTEHDM 371
            ...|:|:..::    ...|....||.|.|..||::|..::|  |.:|||.:|::...:..|:...
pombe   297 HSDLSLLLRKR----VPGEGFITIKKLNGSFDEVIDCAWIG--DDHLAVCSNTEFIDVISTDGTQ 355

  Fly   372 NCKLIVGHSDTVMSLAASQN--LLISVGKDCSVRLWRLQHDKD---CSLEALTQQANCHTSTIGC 431
            ...::.||:|.|::|.:|::  .|.:..||.:||||.|..:.:   | :...|.    ||:::..
pombe   356 VFGVLEGHTDIVLTLDSSEDGVWLATGAKDNTVRLWNLNIEDNVYKC-IHVFTG----HTASVTA 415

  Fly   432 VAMTHNGATGF----ASVSQDGSMKVWQLVRSKEDRNSYSFNLRYAALSHDKEVNCVAYAPNNKL 492
            ||:......|:    ||.|||.::|.:.| .|:.:::.:|....:...:||::||.:..:.:.::
pombe   416 VALGPLDVNGYPTFLASSSQDRTLKRFNL-GSQLNKSDFSNRAVWTIKAHDRDVNAIQVSKDGRI 479

  Fly   493 IATASQDKTAKVWLAESNTLQGVLRGHTRGVWSVRFSPVDQIVLTSSSDCTLRIWSISNFSCIKR 557
            ||:||||||.|:|.:.:..:.||||||.||||:..|:|..:.:.:.|.|.|:|||::....|::.
pombe   480 IASASQDKTIKLWDSSTGEVVGVLRGHRRGVWACSFNPFSRQLASGSGDRTIRIWNVDTQQCVQT 544

  Fly   558 FDQEC-TILRAEFLDHGKFIISAASDGLLKLWNIKTNTCLQSLDEHNDRVWALAVSARSNRFFYT 621
            .:... .||:..::..|..::|||:|||:|:|::.:..|:.:||.|.||||||| |........:
pombe   545 LEGHTGAILKLIYISQGTQVVSAAADGLVKVWSLSSGECVATLDNHEDRVWALA-SRFDGSLLVS 608

  Fly   622 GGADSKLIRFGDVTQ---VTRNEALDKRQAALEQEQTLHSLLHAQKQLHKAFVLALNLDKPKASF 683
            ||||:.:..:.|||:   ..:.|.|::|   :|.||.| |.....:...:|..|||:||:|....
pombe   609 GGADAVVSVWKDVTEEYIAKQAEELERR---VEAEQLL-SNFEQTEDWQQAIALALSLDRPHGLL 669

  Fly   684 DIINHFVRKRDEPG-------LRQLVDQLNVDQRVALLQHVKAWTTNSRHSQAGNMILKYLIGDA 741
            .:....:....:|.       :..::.||...|.:.|.|.::.|.|||:.|.....:|:.|:..
pombe   670 RLFERVMTAPHQPNSITGNKDVDNVLVQLPDHQLIILFQRIRDWNTNSKTSMVAQRLLRLLLHS- 733

  Fly   742 LLDPKARFYYNG--NMVEVLTPYVQRHFKRVTELNKDLAFLEFIV 784
             ..|:.....:|  ::::.:.||..||..||.:|.:|...:::::
pombe   734 -YSPEHLLKLSGIKDILDSMIPYTDRHLARVNDLIEDSYIVDYVI 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1671	NP_610526.1	WD40 repeat	22..54	CDD:293791	8/31 (26%)
		WD40	64..571	CDD:225201	147/535 (27%)
		WD40 repeat	82..115	CDD:293791	9/34 (26%)
		WD40	118..455	CDD:238121	95/362 (26%)
		WD40 repeat	122..159	CDD:293791	10/36 (28%)
		WD40 repeat	167..206	CDD:293791	9/40 (23%)
		WD40 repeat	209..236	CDD:293791	8/26 (31%)
		WD40 repeat	299..335	CDD:293791	9/35 (26%)
		WD40	329..631	CDD:238121	104/311 (33%)
		WD40 repeat	340..377	CDD:293791	8/36 (22%)
		WD40 repeat	430..476	CDD:293791	12/49 (24%)
		WD40 repeat	481..517	CDD:293791	14/35 (40%)
		WD40 repeat	524..559	CDD:293791	10/34 (29%)
		WD40 repeat	564..600	CDD:293791	12/35 (34%)
		WD40 repeat	608..657	CDD:293791	17/51 (33%)
		Utp13	653..787	CDD:285789	34/141 (24%)
utp13	NP_587989.2	WD40	52..542	CDD:225201	144/517 (28%)
		WD40	62..535	CDD:238121	141/496 (28%)
		WD40 repeat	65..101	CDD:293791	9/35 (26%)
		WD40 repeat	106..142	CDD:293791	10/36 (28%)
		WD40 repeat	149..186	CDD:293791	8/38 (21%)
		WD40 repeat	192..231	CDD:293791	11/44 (25%)
		WD40	316..619	CDD:238121	104/311 (33%)
		WD40 repeat	328..362	CDD:293791	8/35 (23%)
		WD40 repeat	367..408	CDD:293791	12/41 (29%)
		WD40 repeat	414..463	CDD:293791	12/49 (24%)
		WD40 repeat	468..504	CDD:293791	14/35 (40%)
		WD40 repeat	511..546	CDD:293791	10/34 (29%)
		WD40 repeat	552..588	CDD:293791	12/35 (34%)
		Utp13	640..777	CDD:285789	34/139 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	50	1.000	Domainoid score	I3390
eggNOG	1	0.900	-	-		E1_KOG0319
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4711
Inparanoid	1	1.050	290	1.000	Inparanoid score	I637
OMA	1	1.010	-	-		QHG53916
OrthoFinder	1	1.000	-	-		FOG0003383
OrthoInspector	1	1.000	-	-		oto101608
orthoMCL	1	0.900	-	-		OOG6_102171
Panther	1	1.100	-	-	LDO	PTHR19854
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1422
SonicParanoid	1	1.000	-	-		X2981
TreeFam	1	0.960	-	-
	14	13.860