DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1671 and Tbl3

DIOPT Version :9

Sequence 1:	NP_610526.1	Gene:	CG1671 / 36019	FlyBaseID:	FBgn0033454	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_663371.2	Gene:	Tbl3 / 213773	MGIID:	2384863	Length:	801	Species:	Mus musculus

Alignment Length:	823	Identity:	260/823 - (31%)
Similarity:	429/823 - (52%)	Gaps:	86/823 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AGIS--EKSYAAEARYTNFYAGGDIAWSPNGHHLYCLNGSAVNQVDVQTSQILNSYGLSSPSADN 65
            ||:.  :.:||.|.:...||.||.......||:|:|:.|:.||.:||.:..:|.|
Mouse     6 AGLCRFKANYAVERKIEPFYKGGKAQLDQTGHYLFCVCGTKVNILDVASGALLRS---------- 60

  Fly    66 KRPAELDNIDVEEDTITCFGLS--QEHLVTAHRSGLLRLWQLDTGKLVKLWKAQHKGPVIRVEFS 128
                 |:..|.|:  ||.|.||  .|.||||.|:.||..|....|.:.:||||.|..||..:.|.
Mouse    61 -----LEQEDQED--ITSFDLSPDDEVLVTASRALLLAQWAWREGTVTRLWKAIHTAPVASMAFD 118

  Fly   129 PCGRLICTSGGADATLRLWDYSNNSCLGALKDFPGPAWLLVFHPNVLRKEIYAGGSDNTVYAWNY 193
            ....|:.| ||.|..:|:||...:......:..||...|:.|||:..|..:::...|.::..|:.
Mouse   119 ATSTLLAT-GGCDGAVRVWDIVQHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSAVDTSIRVWSL 182

  Fly   194 ETKTLVHKMRGHLSQVTGLSFKSNASDCNEIVTVSRDKVMIVWQLQEQLESKQLKVLPLYDELEG 258
            :.::.:..:..|.|.||.|||....   :.:::..|||:.|||.||..   :..:.:|:::.:|.
Mouse   183 QDRSCLAVLTAHYSAVTSLSFSEGG---HTMLSSGRDKICIVWDLQSY---QTTRTVPVFESVEA 241

  Fly   259 VVY---------------------ADEGQLIIVASGSGKLQQVDPKSWKIRDILSQSDFQISRLL 302
            .|.                     .|:|.|.:..:.||:.....|:...:|          ..|.
Mouse   242 SVLLPEQPAPALGVKSSGLHFLTAGDQGILRVWEAASGQCVYTQPQMPGLR----------QELT 296

  Fly   303 HCSELKQ---LALVTTEQNILVYDVETLEPIKHLVGYNDEILDMCFMGEHDRYLAVATNSKHFKL 364
            ||:..:.   |..||.:.|:|:|:..:|:..|...||::|:||:.|:|..|.::.||:||...|:
Mouse   297 HCTLARAADLLLTVTADHNLLLYEAHSLQLQKQFAGYSEEVLDVRFLGPSDSHIVVASNSPCLKV 361

  Fly   365 YDTEHDMNCKLIVGHSDTVMSLAASQN--LLISVGKDCSVRLWRLQHDKDCSLEALTQQANCHTS 427
            ::.: .:.|:::.||:|.|::|...:.  |..|..||.|:|:|::   ......|...|.:.||.
Mouse   362 FELQ-TLACQILHGHTDIVLALDVFRKGWLFASCAKDQSIRIWKM---NKAGQVACVAQGSGHTH 422

  Fly   428 TIGCVAMTHNGATGFASVSQDGSMKVWQLVR------SKEDRNSYSFNLRYAALSHDKEVNCVAY 486
            ::|.:..:....:...:.|||.::|:|.|..      :..|........:.....|||::|.:|.
Mouse   423 SVGTICCSRLKESFLVTGSQDCTVKLWPLPEALLAKSTAADSGPVLLQAQTTRRCHDKDINSLAV 487

  Fly   487 APNNKLIATASQDKTAKVWLAESNTLQGVLRGHTRGVWSVRFSPVDQIVLTSSSDCTLRIWSISN 551
            :||:||:||.|||:|||:|......|.||..||.||:|:|:|||.||::.|:|:|.|:::|::.:
Mouse   488 SPNDKLLATGSQDRTAKLWALPQCQLLGVFTGHRRGLWNVQFSPTDQVLATASADGTIKLWALQD 552

  Fly   552 FSCIKRFD-QECTILRAEFLDHGKFIISAASDGLLKLWNIKTNTCLQSLDEHNDRVWALAVSARS 615
            |||:|.|: .:.::|:..|:..|..::|:.||||||||.||:|.|:::||.|.|:||.|..|...
Mouse   553 FSCLKTFEGHDASVLKVAFVSRGSQLLSSGSDGLLKLWTIKSNECVRTLDAHEDKVWGLHCSQLD 617

  Fly   616 NRFFYTGGADSKLIRFGDVTQVTRNEALDKRQAALEQEQTLHSLLHAQKQLHKAFVLALNLDKPK 680
            :... |||:||::|.:.|||:..:.|...||:..:.::|.|.:|||.::.| :|..||::||:|.
Mouse   618 DHAI-TGGSDSRIILWKDVTEAEQAEEQAKREEQVIKQQELDNLLHEKRYL-RALGLAISLDRPH 680

  Fly   681 ASFDIINHFVRKRDEPGLRQL---VDQLNVDQRVALLQHVKAWTTNSRHSQAGNMILKYLIGDAL 742
            ....:|...  :||.....:|   |.:|..||:.|||:....|.|||||......:|..|:....
Mouse   681 TVLTVIQAI--RRDPEACEKLEATVLRLRRDQKEALLRFCVTWNTNSRHCHEAQAVLGVLLRHEA 743

  Fly   743 LDPKARFYYNG--NMVEVLTPYVQRHFKRVTELNKDLAFLEFI 783
              |:....|:|  ..:|.|.||.:|||:|::...:...||:|:
Mouse   744 --PEELLAYDGVRGSLEALLPYTERHFQRLSRTLQAATFLDFL 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1671	NP_610526.1	WD40 repeat	22..54	CDD:293791	11/31 (35%)
		WD40	64..571	CDD:225201	161/541 (30%)
		WD40 repeat	82..115	CDD:293791	15/34 (44%)
		WD40	118..455	CDD:238121	92/362 (25%)
		WD40 repeat	122..159	CDD:293791	10/36 (28%)
		WD40 repeat	167..206	CDD:293791	7/38 (18%)
		WD40 repeat	209..236	CDD:293791	9/26 (35%)
		WD40 repeat	299..335	CDD:293791	11/38 (29%)
		WD40	329..631	CDD:238121	111/310 (36%)
		WD40 repeat	340..377	CDD:293791	11/36 (31%)
		WD40 repeat	430..476	CDD:293791	8/51 (16%)
		WD40 repeat	481..517	CDD:293791	18/35 (51%)
		WD40 repeat	524..559	CDD:293791	16/34 (47%)
		WD40 repeat	564..600	CDD:293791	16/35 (46%)
		WD40 repeat	608..657	CDD:293791	15/48 (31%)
		Utp13	653..787	CDD:285789	45/136 (33%)
Tbl3	NP_663371.2	WD40	60..602	CDD:225201	176/579 (30%)
		WD 1	64..105		18/42 (43%)
		WD40 repeat	69..105	CDD:293791	16/35 (46%)
		WD 2	107..146		12/39 (31%)
		WD40	<108..137	CDD:197651	10/29 (34%)
		WD40 repeat	112..149	CDD:293791	10/37 (27%)
		WD40	144..449	CDD:238121	80/324 (25%)
		WD 3	149..190		9/40 (23%)
		WD40 repeat	155..193	CDD:293791	7/37 (19%)
		WD 4	193..232		15/44 (34%)
		WD40 repeat	198..237	CDD:293791	14/44 (32%)
		WD40 repeat	245..286	CDD:293791	5/40 (13%)
		WD 5	245..284		5/38 (13%)
		WD 6	290..329		11/48 (23%)
		WD40	328..633	CDD:238121	111/309 (36%)
		WD 7	332..372		14/40 (35%)
		WD40 repeat	338..374	CDD:293791	11/36 (31%)
		WD 8	374..413		12/41 (29%)
		WD40 repeat	379..418	CDD:293791	11/41 (27%)
		WD 9	419..459		9/39 (23%)
		WD40 repeat	426..476	CDD:293791	7/49 (14%)
		WD 10	477..516		19/38 (50%)
		WD40 repeat	482..518	CDD:293791	18/35 (51%)
		WD 11	519..560		20/40 (50%)
		WD40 repeat	524..560	CDD:293791	16/35 (46%)
		WD 12	562..602		16/39 (41%)
		WD40 repeat	566..590	CDD:293791	10/23 (43%)
		WD 13	604..642		15/38 (39%)
		WD40 repeat	608..634	CDD:293791	10/26 (38%)
		Utp13	654..788	CDD:285789	45/136 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842492
Domainoid	1	1.000	66	1.000	Domainoid score	I9917
eggNOG	1	0.900	-	-		E1_KOG0319
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4711
Inparanoid	1	1.050	420	1.000	Inparanoid score	I1779
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53916
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003383
OrthoInspector	1	1.000	-	-		oto94237
orthoMCL	1	0.900	-	-		OOG6_102171
Panther	1	1.100	-	-	LDO	PTHR19854
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1422
SonicParanoid	1	1.000	-	-		X2981
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790