DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1671 and Y53C12B.1

DIOPT Version :9

Sequence 1:	NP_610526.1	Gene:	CG1671 / 36019	FlyBaseID:	FBgn0033454	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_496100.1	Gene:	Y53C12B.1 / 190203	WormBaseID:	WBGene00013143	Length:	793	Species:	Caenorhabditis elegans

Alignment Length:	825	Identity:	239/825 - (28%)
Similarity:	408/825 - (49%)	Gaps:	86/825 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KSYAAEARYTNFYAGGDIAWSPNGHHLYCLNGSAVNQVDVQTSQILNSYGLSSPSADNKRPAELD 72
            |..||:......|.||.:.||.||..|:....:.|..:|:..:..  ||.:..|.
Worm     6 KEIAAKRSVEAVYTGGTVRWSANGQKLFSTCTNVVKVIDLADNTA--SYTIGDPE---------- 58

  Fly    73 NIDVEEDTITCFGL--SQEHLVTAHRSGLLRLWQ--LDTG----KLVKLWKAQHKGPVIRVEFSP 129
                :|..|||..:  ::..|:.|:.:.::|.:.  ||..    :|.:.||..|..|::.:||:.
Worm    59 ----DELRITCTAVDKNRNRLLVAYNNQIIREYSIPLDPSTTKPELARTWKTIHTAPILVMEFNE 119

  Fly   130 CGRLICTSGGADATLRLWDYSNNSCLGALKDFPGPAWL--LVFHPNVLRKEIYAGGSDNTVYAWN 192
            .|.|:.| |.||..:::|:.:...|...||   ||:.:  ::|..:......|..|..|......
Worm   120 EGHLLAT-GSADHIVKVWNLTEQQCTHTLK---GPSVVSAILFGKHEKLVVGYIEGQLNLYNIMR 180

  Fly   193 YETKTLVHKMRGHLSQVTGLSFKSNASDCNEIVTVSRDKVMIVWQLQEQLESKQLKVLPLYDELE 257
            ...|.||:..:.|.|.:|.|   ....|...:|.:|||:.|.:.:.:.|   :.|:|||||:.:|
Worm   181 GAPKKLVNTWKSHNSHITAL---LQVPDSRVVVALSRDQTMSIHETETQ---ETLRVLPLYESIE 239

  Fly   258 GVVYADEGQLIIVASGSGKLQQVDPKSWKIRDILSQSDFQISRLLHCSELKQLA---------LV 313
            |......|.|..|.. .|.:::.         ::..:.....:.:..|.|..||         .:
Worm   240 GGAIGHNGNLFTVGE-EGVVKEF---------VIETAKLVRKKRIASSNLDHLAYDVVSNRFLAI 294

  Fly   314 TTEQNILVYDVETLEPIKHLVGYNDEILDMCFMGEHDRYLAVATNSKHFKLYDTEHDMNCKLIVG 378
            :.|||:::.|.|.|:..:.:||::|||...|.:|:.:.::|||:|:...:||:|: .::|:||.|
Worm   295 SAEQNLIILDFENLKIARQIVGFHDEIYSCCLLGKDESHMAVASNTSEIRLYNTK-TLDCQLIRG 358

  Fly   379 HSDTVMSLAA---SQNLLISVGKDCSVRLWRL---QHDKDCSLEALTQQANCHTSTIGCVAMTHN 437
            |:::|:|:.:   ..:||.|..||.|:..|||   ..:..||.......|..|.:|:..:|:::.
Worm   359 HTESVLSVVSPTWDTSLLASCSKDNSIIFWRLVTSPENDSCSTLVPVAAATGHANTVTALAISNT 423

  Fly   438 GATGF-ASVSQDGSMKVWQL----------VRSKED--RNSYSFNLRYAALSHDKEVNCVAYAPN 489
            |...| ||||.|.::|:|.|          :.:::|  ............::|.|:||||..:.:
Worm   424 GRAPFLASVSTDCTIKLWGLGVSTKLKEVKIDAEKDFVEQLPKLTCSSTMVAHGKDVNCVDISES 488

  Fly   490 NKLIATASQDKTAKVWLAESNTLQ----GVLRGHTRGVWSVRFSPVDQIVLTSSSDCTLRIWSIS 550
            :.||||...||..|:|..:::.:|    |.|.||.|||..|:|:.....:.:.|.|.|::||:||
Worm   489 DALIATGGMDKLVKLWQVDTHKMQLGIAGTLSGHRRGVGDVKFAKNSHKLASCSGDMTIKIWNIS 553

  Fly   551 NFSCIKRFD-QECTILRAEFLDHGKFIISAASDGLLKLWNIKTNTCLQSLDEHNDRVWALAVSAR 614
            ..||::... ..|.:.|..|..:...:|||.|.|::|:|.|||..|..|:|.|.|::|:|:.:..
Worm   554 EKSCLQTISGHSCAVFRVIFARNDSQLISADSAGIIKIWTIKTADCECSIDAHTDKIWSLSKNHN 618

  Fly   615 SNRFFYTGGADSKLIRFGDVTQVTRNEALDKRQAALEQEQTLHSLLHAQKQLHKAFVLALNLDKP 679
            .:. |.|.|.|.:::.:.|||:..:....:||:.|:||:|||.:|| :||:..:|.|.||.|.||
Worm   619 ESE-FVTAGTDGRIVVWKDVTEEKQKAEDNKRREAIEQDQTLTNLL-SQKRYSEALVFALTLAKP 681

  Fly   680 KASFDIINHFVRKRDEPGLRQLVDQLNVDQRVALLQHVKAWTTNSRHSQAGNMILKYLIGDALLD 744
            ..:|.:||..:.:.....|...:.:|:..|...|||....|.||||.|.....:|..::  .::|
Worm   682 FCAFKVINALMAEETPEELGSAIRRLDTRQIEILLQFTVKWNTNSRTSSVAQRVLYEIV--HIVD 744

  Fly   745 PKARFYYNG--NMVEVLTPYVQRHFKRVTELNKDLAFLEFIVKCM 787
            |:......|  ..:|...||.|||..|:....:|::..:|:.:.|
Worm   745 PEELVSMPGAYGYIESFLPYTQRHMDRLDRAKQDVSLFDFVWRQM 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1671	NP_610526.1	WD40 repeat	22..54	CDD:293791	9/31 (29%)
		WD40	64..571	CDD:225201	151/549 (28%)
		WD40 repeat	82..115	CDD:293791	8/40 (20%)
		WD40	118..455	CDD:238121	100/354 (28%)
		WD40 repeat	122..159	CDD:293791	10/36 (28%)
		WD40 repeat	167..206	CDD:293791	7/40 (18%)
		WD40 repeat	209..236	CDD:293791	8/26 (31%)
		WD40 repeat	299..335	CDD:293791	10/44 (23%)
		WD40	329..631	CDD:238121	104/325 (32%)
		WD40 repeat	340..377	CDD:293791	12/36 (33%)
		WD40 repeat	430..476	CDD:293791	12/58 (21%)
		WD40 repeat	481..517	CDD:293791	14/39 (36%)
		WD40 repeat	524..559	CDD:293791	11/34 (32%)
		WD40 repeat	564..600	CDD:293791	14/35 (40%)
		WD40 repeat	608..657	CDD:293791	15/48 (31%)
		Utp13	653..787	CDD:285789	42/135 (31%)
Y53C12B.1	NP_496100.1	WD40	<22..137	CDD:392136	32/131 (24%)
		WD40 repeat	22..58	CDD:293791	9/37 (24%)
		WD40 repeat	64..107	CDD:293791	10/42 (24%)
		WD40	100..441	CDD:238121	103/361 (29%)
		WD40 repeat	112..149	CDD:293791	12/40 (30%)
		WD40 repeat	153..192	CDD:293791	7/38 (18%)
		WD40 repeat	197..255	CDD:293791	20/64 (31%)
		WD40	312..635	CDD:238121	104/324 (32%)
		WD40 repeat	322..358	CDD:293791	12/36 (33%)
		WD40 repeat	364..410	CDD:293791	13/45 (29%)
		WD40 repeat	415..474	CDD:293791	12/58 (21%)
		WD40 repeat	481..520	CDD:293791	13/38 (34%)
		WD40 repeat	526..562	CDD:293791	12/35 (34%)
		WD40 repeat	568..604	CDD:293791	14/35 (40%)
		WD40 repeat	610..634	CDD:293791	6/24 (25%)
		Utp13	656..789	CDD:370012	42/135 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162499
Domainoid	1	1.000	85	1.000	Domainoid score	I5229
eggNOG	1	0.900	-	-		E1_KOG0319
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4711
Inparanoid	1	1.050	346	1.000	Inparanoid score	I1367
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53916
OrthoDB	1	1.010	-	-		D1112002at2759
OrthoFinder	1	1.000	-	-		FOG0003383
OrthoInspector	1	1.000	-	-		oto17363
orthoMCL	1	0.900	-	-		OOG6_102171
Panther	1	1.100	-	-	LDO	PTHR19854
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1422
SonicParanoid	1	1.000	-	-		X2981
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.800