DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG1671 and Wdr5

DIOPT Version :9

Sequence 1:NP_610526.1 Gene:CG1671 / 36019 FlyBaseID:FBgn0033454 Length:787 Species:Drosophila melanogaster
Sequence 2:NP_543124.1 Gene:Wdr5 / 140858 MGIID:2155884 Length:334 Species:Mus musculus


Alignment Length:298 Identity:65/298 - (21%)
Similarity:115/298 - (38%) Gaps:80/298 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   425 HTSTIGCVAMTHNGATGFASVSQDGSMKVWQLVRSKEDRNSYSFNLRYAALSHDKEVNCVAYAPN 489
            ||..:..|..:.|| ...||.|.|..:|:|         .:|..........|...::.||::.:
Mouse    44 HTKAVSSVKFSPNG-EWLASSSADKLIKIW---------GAYDGKFEKTISGHKLGISDVAWSSD 98

  Fly   490 NKLIATASQDKTAKVWLAESNTLQGVLRGHTRGVWSVRFSPVDQIVLTSSSDCTLRIWSISNFSC 554
            :.|:.:||.|||.|:|...|......|:||:..|:...|:|...::::.|.|.::|||.:....|
Mouse    99 SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC 163

  Fly   555 IK------------------------RFDQECTI--------LR------------AEFLDHGKF 575
            :|                        .:|..|.|        |:            .:|..:||:
Mouse   164 LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKY 228

  Fly   576 IISAASDGLLKLWNIKTNTCLQSLDEHNDRVWALAV--SARSNRFFYTGGADSKLIRFGDVTQVT 638
            |::|..|..||||:.....||::...|.:..:.:..  |....::..:|..|:.:.    :..:.
Mouse   229 ILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVY----IWNLQ 289

  Fly   639 RNEALDKRQ--------------------AALEQEQTL 656
            ..|.:.|.|                    ||||.::|:
Mouse   290 TKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTI 327

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1671NP_610526.1 WD40 repeat 22..54 CDD:293791
WD40 64..571 CDD:225201 42/189 (22%)
WD40 repeat 82..115 CDD:293791
WD40 118..455 CDD:238121 10/29 (34%)
WD40 repeat 122..159 CDD:293791
WD40 repeat 167..206 CDD:293791
WD40 repeat 209..236 CDD:293791
WD40 repeat 299..335 CDD:293791
WD40 329..631 CDD:238121 57/251 (23%)
WD40 repeat 340..377 CDD:293791
WD40 repeat 430..476 CDD:293791 10/45 (22%)
WD40 repeat 481..517 CDD:293791 11/35 (31%)
WD40 repeat 524..559 CDD:293791 9/58 (16%)
WD40 repeat 564..600 CDD:293791 14/55 (25%)
WD40 repeat 608..657 CDD:293791 11/71 (15%)
Utp13 653..787 CDD:285789 1/4 (25%)
Wdr5NP_543124.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..31
WD40 37..331 CDD:238121 65/298 (22%)
WD 1 43..82 12/47 (26%)
WD40 repeat 48..85 CDD:293791 10/46 (22%)
WD 2 85..126 12/40 (30%)
WD40 repeat 91..127 CDD:293791 12/35 (34%)
WD 3 128..168 11/39 (28%)
WD40 repeat 132..168 CDD:293791 10/35 (29%)
WD 4 169..208 4/38 (11%)
WD40 repeat 175..210 CDD:293791 4/34 (12%)
WD 5 212..253 12/40 (30%)
WD40 repeat 217..253 CDD:293791 12/35 (34%)
WD 6 256..296 4/43 (9%)
WD40 repeat 261..298 CDD:293791 5/40 (13%)
WD 7 299..333 5/29 (17%)
WD40 repeat 304..330 CDD:293791 5/24 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1422
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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