DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prosalpha7 and PRE10

DIOPT Version :9

Sequence 1:	NP_724834.1	Gene:	Prosalpha7 / 36018	FlyBaseID:	FBgn0023175	Length:	253	Species:	Drosophila melanogaster
Sequence 2:	NP_015007.1	Gene:	PRE10 / 854544	SGDID:	S000005889	Length:	288	Species:	Saccharomyces cerevisiae

Alignment Length:	262	Identity:	115/262 - (43%)
Similarity:	163/262 - (62%)	Gaps:	14/262 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTIGTGYDLSASQFSPDGRVFQIDYASKAVEKSGTVIGIRGKDAVVLAVEKIITSKLYEPDAGG 65
            |::||||||||.|.||||||.||::||.||||...|.|||:..|.||.||||:|||||..|....
Yeast     1 MTSIGTGYDLSNSVFSPDGRNFQVEYAVKAVENGTTSIGIKCNDGVVFAVEKLITSKLLVPQKNV 65

  Fly    66 RIFTIEKNIGMAVAGLVADGNFVADIARQEAANYRQQFEQAIPLKHLCHRVAGYVHAYTLYSAVR 130
            :|..::::||...:||:.||..:.:..|:|||::::.::..||:.....|:..||.|:|||::||
Yeast    66 KIQVVDRHIGCVYSGLIPDGRHLVNRGREEAASFKKLYKTPIPIPAFADRLGQYVQAHTLYNSVR 130

  Fly   131 PFGLSIILASWDEVEGPQLYKIEPSGSSFGYFACASGKAKQLAKTEMEKLKMD-----MRTDELV 190
            |||:|.|....|: .|..||.:|||||.:||...|:||.:|.||.|:||| :|     :...|.|
Yeast   131 PFGVSTIFGGVDK-NGAHLYMLEPSGSYWGYKGAATGKGRQSAKAELEKL-VDHHPEGLSAREAV 193

  Fly   191 ESAGEIIYKVHDELKDKDFRFEMGLVG-RVTGGLHLINPSELTEK----ARKA--GDAANKDEDS 248
            :.|.:|||..|::.|:|||..|:.... ..|.|||.....:|.::    |:|.  ||....::||
Yeast   194 KQAAKIIYLAHEDNKEKDFELEISWCSLSETNGLHKFVKGDLLQEAIDFAQKEINGDDDEDEDDS 258

  Fly   249 DN 250
            ||
Yeast   259 DN 260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prosalpha7	NP_724834.1	proteasome_alpha_type_3	5..216	CDD:239720	100/215 (47%)
Prosalpha7	NP_724834.1	PRE1	6..231	CDD:223711	103/230 (45%)
PRE10	NP_015007.1	proteasome_alpha_type_3	5..219	CDD:239720	100/215 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343795
Domainoid	1	1.000	148	1.000	Domainoid score	I962
eggNOG	1	0.900	-	-		E1_COG0638
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2082
Inparanoid	1	1.050	201	1.000	Inparanoid score	I857
Isobase	1	0.950	-	0	Normalized mean entropy	S453
OMA	1	1.010	-	-		QHG53517
OrthoFinder	1	1.000	-	-		FOG0004628
OrthoInspector	1	1.000	-	-		oto99841
orthoMCL	1	0.900	-	-		OOG6_102011
Panther	1	1.100	-	-	LDO	PTHR11599
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1005
SonicParanoid	1	1.000	-	-		X3238
TreeFam	1	0.960	-	-
	16	15.740