DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prosalpha7 and pre10

DIOPT Version :9

Sequence 1:	NP_724834.1	Gene:	Prosalpha7 / 36018	FlyBaseID:	FBgn0023175	Length:	253	Species:	Drosophila melanogaster
Sequence 2:	NP_588040.1	Gene:	pre10 / 2539378	PomBaseID:	SPCC1795.04c	Length:	253	Species:	Schizosaccharomyces pombe

Alignment Length:	250	Identity:	107/250 - (42%)
Similarity:	157/250 - (62%)	Gaps:	7/250 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTIGTGYDLSASQFSPDGRVFQIDYASKAVEKSGTVIGIRGKDAVVLAVEKIITSKLYEPDAGG 65
            ||:|||||||... ||||||:||.:||.||||.:.|.|||:.:|.|:||:||::||||.:|....
pombe     1 MSSIGTGYDLGLF-FSPDGRLFQAEYAYKAVENASTCIGIKCEDGVILALEKVVTSKLLKPRVNN 64

  Fly    66 RIFTIEKNIGMAVAGLVADGNFVADIARQEAANYRQQFEQAIPLKHLCHRVAGYVHAYTLYSAVR 130
            ||.:::::||:|..|.:.||..:...||.||.::|..:...||...:..|:..||..:|.||:||
pombe    65 RIGSVDRHIGIATTGFIPDGQHIVKRARDEATSWRDNYGSPIPGTVIADRLGNYVQLFTCYSSVR 129

  Fly   131 PFGLSIILASWDEVEGPQLYKIEPSGSSFGYFACASGKAKQLAKTEMEKLKM-DMRTDELVESAG 194
            |||:...:|::|. |||.||.:||:|..:||...|:||.:|:|:.|:|||.. .::..:.|:.|.
pombe   130 PFGVMSFVATYDS-EGPHLYMVEPNGVYWGYNGAAAGKGRQVARNELEKLNFSSLKMKDAVKEAA 193

  Fly   195 EIIYKVHDELKDKDFRFEMGLVGRVTGGLHLINPSELTEK----ARKAGDAANKD 245
            .|:|..|||..:|:...||..||..|.|:|...|.||.::    ||:..|...:|
pombe   194 RILYATHDEENNKEHEIEMTWVGVETNGIHTPVPDELLQEAEAYARRIADGEEED 248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prosalpha7	NP_724834.1	proteasome_alpha_type_3	5..216	CDD:239720	92/211 (44%)
Prosalpha7	NP_724834.1	PRE1	6..231	CDD:223711	97/225 (43%)
pre10	NP_588040.1	proteasome_alpha_type_3	5..215	CDD:239720	92/211 (44%)
pre10	NP_588040.1	PRE1	6..241	CDD:223711	101/236 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	152	1.000	Domainoid score	I1084
eggNOG	1	0.900	-	-		E1_COG0638
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2082
Inparanoid	1	1.050	205	1.000	Inparanoid score	I978
OMA	1	1.010	-	-		QHG53517
OrthoFinder	1	1.000	-	-		FOG0004628
OrthoInspector	1	1.000	-	-		oto101519
orthoMCL	1	0.900	-	-		OOG6_102011
Panther	1	1.100	-	-	LDO	PTHR11599
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1005
SonicParanoid	1	1.000	-	-		X3238
TreeFam	1	0.960	-	-
	14	13.860