DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sting and Sting1

DIOPT Version :9

Sequence 1:NP_001286256.1 Gene:Sting / 36016 FlyBaseID:FBgn0033453 Length:343 Species:Drosophila melanogaster
Sequence 2:NP_001102592.1 Gene:Sting1 / 498840 RGDID:1562552 Length:379 Species:Rattus norvegicus


Alignment Length:353 Identity:82/353 - (23%)
Similarity:156/353 - (44%) Gaps:77/353 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    38 RIVATVFLADLLLRLYRCVVEYGSNGRYYL----PEDRLWIILRRSC-----------TYNN--- 84
            ::.|.|.|...|:.|: ...|..|:..:||    ...:|.::|::.|           .|..   
  Rat    19 KLAAFVLLVGSLMSLW-MTGEPPSHTLHYLALHVASQQLGLLLKKLCCLAEELCHVQSRYQGSYW 82

  Fly    85 RSIYLIVG-------FLLVAFF---RISVTGNYRNVMPTTLFLFQMPLYWIWSFTDMDQSTLSYS 139
            :::...||       .:|::|:   .:..|.:.|......:.:....|    |.| :|..:|:.:
  Rat    83 KAVRACVGSPICFMALILLSFYFYCSLENTSDLRLAWHLGILVLSKSL----SMT-LDLQSLAPA 142

  Fly   140 H--WIRDSHGLDYAAGMASNYFHGYLKLSLPERKDDGLKHRLAMYEDKNNVTF---GIKRLVIL- 198
            .  .:.:....:.|.|:|.:|:.|||||.||     ||:.|:.|:...:|...   |.:||.|| 
  Rat   143 EVSAVCEEKNFNVAHGLAWSYYIGYLKLILP-----GLQARIRMFNQLHNNMLSGAGSRRLYILF 202

  Fly   199 -----IPDEMFVNGVLESHLLDKAEP-------LETQFINRAGV-YRPFKHDVYRMNKKVNGRTY 250
                 :||::.|           |:|       |..|..:|||| .|.:.:.||.:.:  ||:..
  Rat   203 PLDCGVPDDLSV-----------ADPNIRFRDMLPQQNTDRAGVKNRAYSNSVYELLE--NGQPA 254

  Fly   251 YFAV-EGATPMISFFDATYSNLSGTWQMQELKREIWIKFYKHLKELITTWPETRDLVELIIYNSH 314
            ...: |.|||:.:.|..:....:|..:...|::.  ..|.:.|:|::...||:|:...||:|...
  Rat   255 GACILEYATPLQTLFAMSQDGKAGFSREDRLEQA--KLFCRTLEEILADVPESRNHCRLIVYQES 317

  Fly   315 DSKGNLVDVGELLVAHMQNKTKTIDEIS 342
            : :||...:.:.::.|::.:.|  :|::
  Rat   318 E-EGNSFSLSQEVLRHIRQEEK--EEVT 342

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
StingNP_001286256.1 TMEM173 33..335 CDD:291670 80/344 (23%)
Sting1NP_001102592.1 Mediates interaction with ZDHHC1 and ZDHHC11. /evidence=ECO:0000250|UniProtKB:Q86WV6 1..190 40/181 (22%)
TMEM173 44..337 CDD:291670 73/318 (23%)
Cyclic dinucleotide-binding domain (CBD). /evidence=ECO:0000269|PubMed:26669264 153..340 57/209 (27%)
2',3'-cGAMP binding. /evidence=ECO:0000305|PubMed:26669264 162..167 1/4 (25%)
2',3'-cGAMP binding. /evidence=ECO:0000305|PubMed:26669264 238..241 1/2 (50%)
c-di-GMP binding. /evidence=ECO:0000250|UniProtKB:Q3TBT3 238..241 1/2 (50%)
C-terminal tail (CTT). /evidence=ECO:0000250|UniProtKB:Q86WV6 340..379 1/3 (33%)
pLxIS motif. /evidence=ECO:0000250|UniProtKB:Q86WV6 363..366
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166338553
Domainoid 1 1.000 55 1.000 Domainoid score I10895
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 56 1.000 Inparanoid score I5341
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D371197at33208
OrthoFinder 1 1.000 - - FOG0008120
OrthoInspector 1 1.000 - - oto96779
orthoMCL 1 0.900 - - OOG6_110638
Panther 1 1.100 - - LDO PTHR34339
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
98.900

Return to query results.
Submit another query.