DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sting and STING1

DIOPT Version :9

Sequence 1:	NP_001286256.1	Gene:	Sting / 36016	FlyBaseID:	FBgn0033453	Length:	343	Species:	Drosophila melanogaster
Sequence 2:	NP_938023.1	Gene:	STING1 / 340061	HGNCID:	27962	Length:	379	Species:	Homo sapiens

Alignment Length:	206	Identity:	56/206 - (27%)
Similarity:	105/206 - (50%)	Gaps:	33/206 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 AAGMASNYFHGYLKLSLPERKDDGLKHRLAMY-EDKNNVTFGI--KRLVILIPDEMFVNGVLESH 212
            |.|:|.:|:.|||:|.|||     |:.|:..| :..||:..|.  :||.||:|.:.   ||.::
Human   156 AHGLAWSYYIGYLRLILPE-----LQARIRTYNQHYNNLLRGAVSQRLYILLPLDC---GVPDN- 211

  Fly   213 LLDKAEP-------LETQFINRAGVY-RPFKHDVYRMNKKVNG-RTYYFAVEGATPMISFFDATY 268
             |..|:|       |..|..:.||:. |.:.:.:|.:.:  || |.....:|.|||:.:.|..:.
Human   212 -LSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLE--NGQRAGTCVLEYATPLQTLFAMSQ 273

  Fly   269 SNLSGTWQMQELKREIWIKFYKHLKELITTWPETRDLVELIIYN--SHDSKGNLVDVGELLVAHM 331
            .:.:|..:...|::.  ..|.:.|::::...||:::...||.|.  :.||..:|   .:.::.|:
Human   274 YSQAGFSREDRLEQA--KLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSL---SQEVLRHL 333

  Fly   332 QNKTKTIDEIS 342
            :.:.|  :|::
Human   334 RQEEK--EEVT 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sting	NP_001286256.1	TMEM173	33..335	CDD:291670	54/197 (27%)
STING1	NP_938023.1	Mediates interaction with ZDHHC1 and ZDHHC11. /evidence=ECO:0000269\|PubMed:25299331, ECO:0000269\|PubMed:28331227	1..190		16/38 (42%)
		TMEM173	44..337	CDD:317429	54/197 (27%)
		Cyclic dinucleotide-binding domain (CBD). /evidence=ECO:0000269\|PubMed:22705373	153..340		55/202 (27%)
		c-di-GMP binding. /evidence=ECO:0000269\|PubMed:22728658, ECO:0000269\|PubMed:22728659, ECO:0000269\|PubMed:22728660, ECO:0007744\|PDB:4EMT, ECO:0007744\|PDB:4F5D, ECO:0007744\|PDB:4F5Y	238..241		1/2 (50%)
		C-terminal tail (CTT). /evidence=ECO:0000269\|PubMed:22705373	340..379		1/3 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..370		0/2 (0%)
		pLxIS motif. /evidence=ECO:0000269\|PubMed:25636800	363..366
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144856
Domainoid	1	1.000	41	1.000	Domainoid score	I12519
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D371197at33208
OrthoFinder	1	1.000	-	-		FOG0008120
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_110638
Panther	1	1.100	-	-	LDO	PTHR34339
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.850