DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vamp7 and sybl1

DIOPT Version :9

Sequence 1:	NP_001286255.1	Gene:	Vamp7 / 36015	FlyBaseID:	FBgn0266186	Length:	218	Species:	Drosophila melanogaster
Sequence 2:	XP_005157192.1	Gene:	sybl1 / 393236	ZFINID:	ZDB-GENE-040426-1055	Length:	220	Species:	Danio rerio

Alignment Length:	217	Identity:	114/217 - (52%)
Similarity:	160/217 - (73%)	Gaps:	0/217 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPILYSVISRGTTVLAKFAECVGNFAEVTEHIIGRIGVHNHKMTYTHGDYLIHYTCENKLVYMCI 65
            |.||::|::||:|||||.|...|||.||||.|:.:|...|:|:||:||.||.||.|..::||:||
Zfish     1 MAILFAVVARGSTVLAKHACFSGNFLEVTEQILAKIPSENNKLTYSHGSYLFHYICHERIVYLCI 65

  Fly    66 TDNEFERSRAFLFLADIKQKFIQTYGLQVATAIAYSMNTEFSKILAQQMVYFSQSREVDTISRVH 130
            ||:||||||||.||.::|::|..|||.:..||:.|:||:|||..||.||.:.|..:..|.::...
Zfish    66 TDDEFERSRAFGFLNEVKKRFQTTYGSRAQTALPYAMNSEFSSTLAAQMKHHSDPKGSDRLTETQ 130

  Fly   131 GQIDELKDIMVKNIDSLRDRGEKLELLVNKTENLSNNSVAFRKASRNLARQMFWKNIRVYVVVGL 195
            .|:|:||.|||:|||.:..|||:||||::|||||.::||.|:..|||||..|..||:::.|:|.:
Zfish   131 MQVDDLKGIMVRNIDLVAQRGERLELLIDKTENLMDSSVTFKTTSRNLAHAMCMKNLKLTVIVVI 195

  Fly   196 VITFIVYVIVSMACGGLAWQSC 217
            |:..::|.|||.|||||:|.:|
Zfish   196 VVLVVLYFIVSGACGGLSWPNC 217

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vamp7	NP_001286255.1	Longin	32..97	CDD:290490	34/64 (53%)
		Synaptobrevin	122..210	CDD:279324	42/87 (48%)
		R-SNARE_VAMP7	124..188	CDD:277224	34/63 (54%)
sybl1	XP_005157192.1	SNC1	1..172	CDD:227472	91/170 (54%)
		Longin	29..98	CDD:290490	37/68 (54%)
		Synaptobrevin	122..210	CDD:279324	42/87 (48%)
		R-SNARE_VAMP7	124..188	CDD:277224	34/63 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592528
Domainoid	1	1.000	99	1.000	Domainoid score	I7046
eggNOG	1	0.900	-	-		E1_COG5143
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4121
Inparanoid	1	1.050	240	1.000	Inparanoid score	I3318
OMA	1	1.010	-	-		QHG53513
OrthoDB	1	1.010	-	-		D1211929at2759
OrthoFinder	1	1.000	-	-		FOG0004661
OrthoInspector	1	1.000	-	-		oto40938
orthoMCL	1	0.900	-	-		OOG6_101193
Panther	1	1.100	-	-	LDO	PTHR21136
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5105
SonicParanoid	1	1.000	-	-		X3273
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800