DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1663 and ZNF93

DIOPT Version :9

Sequence 1:	NP_610521.1	Gene:	CG1663 / 36012	FlyBaseID:	FBgn0033449	Length:	387	Species:	Drosophila melanogaster
Sequence 2:	NP_112495.2	Gene:	ZNF93 / 81931	HGNCID:	13169	Length:	620	Species:	Homo sapiens

Alignment Length:	343	Identity:	95/343 - (27%)
Similarity:	145/343 - (42%)	Gaps:	67/343 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 ESFKNVEFMEEEV-EPNFSPEKEQGHDELASNSHHDYISNQPHKAFYSLQRTSPGVI-QYFIQQL 110
            |::.|:.|:...| :|:.....|||...| :...|:.::|             |.|| .:|.|.|
Human    35 ENYSNLVFLGIVVSKPDLIAHLEQGKKPL-TMKRHEMVAN-------------PSVICSHFAQDL 85

  Fly   111 RRHKFFWITEHGINKKDRMDSSQKVAEALFHRF------HFQL--------DPKVVNASARFLQV 161
                  | .|..|.     ||.|||   :..|:      :.||        :.||.......|
Human    86 ------W-PEQNIK-----DSFQKV---ILRRYEKRGHGNLQLIKRCESVDECKVHTGGYNGL-- 133

  Fly   162 WFERQYVMQLSSSDFRC-RYPKYYHSLLKFMPTNHISVT-------ICEECDRRFLNERLLRLHK 218
               .|......|..|:| :|.|.:|   ||..:|..::.       .|.||.:.|.....|..||
Human   134 ---NQCSTTTQSKVFQCDKYGKVFH---KFSNSNRHNIRHTEKKPFKCIECGKAFNQFSTLITHK 192

  Fly   219 FRVHGGPNPNVCHVCHQSFPLASKLEQHQARYHFKRPEWQCSRCDYNAPSKWDFQQHQAMHAGQR 283
             ::|.|..|.:|..|.::|..:|.|..|: |.|.....::|.:||....:.....:|:.:|.|::
Human   193 -KIHTGEKPYICEECGKAFKYSSALNTHK-RIHTGEKPYKCDKCDKAFIASSTLSKHEIIHTGKK 255

  Fly   284 NYICELCGHSSKTSSALAVHRRTHDQPK-LCCPHCSRQFRENSTLKSHIRKIHDGNSARQVSCDF 347
            .|.||.||.:...||.|..|::.|...| ..|..|.:.|.::|||..| :|||.|.  :...|:.
Human   256 PYKCEECGKAFNQSSTLTKHKKIHTGEKPYKCEECGKAFNQSSTLTKH-KKIHTGE--KPYVCEE 317

  Fly   348 CWRRFKTLELLKLHKLVH 365
            |.:.||...:|..||.:|
Human   318 CGKAFKYSRILTTHKRIH 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1663	NP_610521.1	MttA_Hcf106	<33..>91	CDD:294511	11/43 (26%)
		C2H2 Zn finger	201..222	CDD:275368	7/20 (35%)
		C2H2 Zn finger	259..279	CDD:275368	4/19 (21%)
		C2H2 Zn finger	287..307	CDD:275368	8/19 (42%)
		C2H2 Zn finger	314..335	CDD:275368	8/20 (40%)
ZNF93	NP_112495.2	KRAB	4..62	CDD:214630	8/26 (31%)
		KRAB	6..43	CDD:279668	2/7 (29%)
		C2H2 Zn finger	147..167	CDD:275368	7/22 (32%)
		COG5048	170..612	CDD:227381	54/171 (32%)
		C2H2 Zn finger	175..195	CDD:275368	7/20 (35%)
		C2H2 Zn finger	203..223	CDD:275368	7/20 (35%)
		zf-H2C2_2	215..238	CDD:290200	7/23 (30%)
		C2H2 Zn finger	231..251	CDD:275368	4/19 (21%)
		zf-H2C2_2	244..268	CDD:290200	8/23 (35%)
		C2H2 Zn finger	259..279	CDD:275368	8/19 (42%)
		zf-H2C2_2	272..296	CDD:290200	7/23 (30%)
		C2H2 Zn finger	287..307	CDD:275368	8/20 (40%)
		zf-H2C2_2	300..324	CDD:290200	9/26 (35%)
		C2H2 Zn finger	315..335	CDD:275368	7/19 (37%)
		zf-H2C2_2	328..350	CDD:290200	4/8 (50%)
		C2H2 Zn finger	343..363	CDD:275368
		C2H2 Zn finger	371..391	CDD:275368
		zf-H2C2_2	384..408	CDD:290200
		C2H2 Zn finger	399..419	CDD:275368
		zf-H2C2_2	412..435	CDD:290200
		C2H2 Zn finger	427..447	CDD:275368
		zf-H2C2_2	440..464	CDD:290200
		C2H2 Zn finger	455..475	CDD:275368
		zf-H2C2_2	467..492	CDD:290200
		C2H2 Zn finger	483..503	CDD:275368
		zf-H2C2_2	495..520	CDD:290200
		C2H2 Zn finger	511..531	CDD:275368
		zf-H2C2_2	524..547	CDD:290200
		C2H2 Zn finger	539..559	CDD:275368
		zf-H2C2_2	551..576	CDD:290200
		C2H2 Zn finger	567..587	CDD:275368
		zf-H2C2_2	580..602	CDD:290200
		C2H2 Zn finger	595..615	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010