DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1663 and ZNF595

DIOPT Version :9

Sequence 1:	NP_610521.1	Gene:	CG1663 / 36012	FlyBaseID:	FBgn0033449	Length:	387	Species:	Drosophila melanogaster
Sequence 2:	NP_872330.1	Gene:	ZNF595 / 152687	HGNCID:	27196	Length:	648	Species:	Homo sapiens

Alignment Length:	294	Identity:	76/294 - (25%)
Similarity:	127/294 - (43%)	Gaps:	38/294 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 SNSHHDYISNQPHKAFYSLQRTSPGVIQYFIQQLRRHKFFWITEHGINKKDRMDSSQKVAEALFH 141
            |||:...|.:...|.|   :.|..| ..:::..|.:|.       ||:..::....:|..:| |:
Human   158 SNSNKHKIRHTGEKPF---KCTECG-RSFYMSHLTQHT-------GIHAGEKPYKCEKCGKA-FN 210

  Fly   142 RFHFQLDPKVVNASARFLQVWFERQYVMQLSSSDFR----CRYPKYYHSLLKFMPTNHISVTICE 202
            |.......|.::..        |:.|..:.....||    ....|..|:..|  |..      ||
Human   211 RSTSLSKHKRIHTG--------EKPYTCEECGKAFRRSTVLNEHKKIHTGEK--PYK------CE 259

  Fly   203 ECDRRFLNERLLRLHKFRVHGGPNPNVCHVCHQSFPLASKLEQHQARYHFKRPEWQCSRCDYNAP 267
            ||.:.|.....|..|| ::|.|..|..|..|.::|..::.|.:|:..:..::| ::|..|.....
Human   260 ECGKAFTRSTTLNEHK-KIHTGEKPYKCKECGKAFRWSTSLNEHKNIHTGEKP-YKCKECGKAFR 322

  Fly   268 SKWDFQQHQAMHAGQRNYICELCGHSSKTSSALAVHRRTHDQPKLC-CPHCSRQFRENSTLKSHI 331
            ......:|:.:|.|::.|.||.||.:...||:|.:||..|.:.||. |..|.:.|..:|:|..|
Human   323 QSRSLNEHKNIHTGEKPYTCEKCGKAFNQSSSLIIHRSIHSEQKLYKCEECGKAFTWSSSLNKH- 386

  Fly   332 RKIHDGNSARQVSCDFCWRRFKTLELLKLHKLVH 365
            ::||.|.  :..:|:.|.:.|.....|..||.:|
Human   387 KRIHTGE--KPYTCEECGKAFYRSSHLAKHKRIH 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1663	NP_610521.1	MttA_Hcf106	<33..>91	CDD:294511	4/13 (31%)
		C2H2 Zn finger	201..222	CDD:275368	8/20 (40%)
		C2H2 Zn finger	259..279	CDD:275368	3/19 (16%)
		C2H2 Zn finger	287..307	CDD:275368	9/19 (47%)
		C2H2 Zn finger	314..335	CDD:275368	6/20 (30%)
ZNF595	NP_872330.1	KRAB	4..64	CDD:214630
		C2H2 Zn finger	147..167	CDD:275368	4/8 (50%)
		C2H2 Zn finger	175..194	CDD:275368	5/26 (19%)
		COG5048	198..599	CDD:227381	64/243 (26%)
		C2H2 Zn finger	202..222	CDD:275368	5/20 (25%)
		C2H2 Zn finger	230..250	CDD:275368	3/19 (16%)
		C2H2 Zn finger	258..278	CDD:275368	8/20 (40%)
		C2H2 Zn finger	286..306	CDD:275368	5/19 (26%)
		C2H2 Zn finger	314..334	CDD:275368	3/19 (16%)
		C2H2 Zn finger	342..362	CDD:275368	9/19 (47%)
		C2H2 Zn finger	370..390	CDD:275368	6/20 (30%)
		C2H2 Zn finger	398..418	CDD:275368	6/19 (32%)
		C2H2 Zn finger	426..446	CDD:275368
		C2H2 Zn finger	454..474	CDD:275368
		C2H2 Zn finger	482..502	CDD:275368
		C2H2 Zn finger	510..530	CDD:275368
		C2H2 Zn finger	538..558	CDD:275368
		C2H2 Zn finger	566..586	CDD:275368
		C2H2 Zn finger	594..614	CDD:275368
		C2H2 Zn finger	622..642	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100