Protein Alignment dila and Cep131

DIOPT Version :9

• Sequence 1: NP_001137629.2
• Gene: dila / 36010
• FlyBaseID: FBgn0033447
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_001101780.1
• Gene: Cep131 / 360672
• RGDID: 1307745
• Length: 1069
• Species: Rattus norvegicus
• Alignment Length: 1260
• Identity: 291/1260 - (23%)
• Similarity: 511/1260 - (40%)
• Gaps: 313/1260 - (24%)

  Fly     5 LKGSQVSSERHGLPPFGLGTKSGQPQ------INLATRQKTKP------KYTSRSLTTLHNPCPH 57
            :|||:..|          .|..|.|:      |.|......:|      |...||::......|.
  Rat     1 MKGSRTIS----------ATPEGSPEGMDLSLIGLPLPMSQRPGSASAAKSIFRSVSVATGSEPR 55

  Fly    58 FR---------PRSANFLQQRSRSS-----PFLGRPQSADPKFGRRLSNYFVEKELRNGGKRQVS 108
            .:         ||:.|.| :||.|:     .:.|.|:.|:|      :::.:..|....|:|:|:
  Rat    56 KKALEATGPGGPRAINNL-RRSNSTTQVNQSWTGSPRPAEP------TDFLMLFEGSTSGRRRVA 113

  Fly   109 SNDLLKSLLEEPIKRSWLCRSTCNSSESDYSLHKRTPDSSEEGEQFLVNMPVGEKVKSYS---SY 170
            |...:.|  |:  ..:|   :..:....|::    :|.:|:...  .::..:|.:.|..|   |:
  Rat   114 SFSKVSS--EK--GATW---NVLDDQPRDFA----SPANSQSPS--TLDSALGPRRKECSLAPSF 165

  Fly   171 SGNQGLSNGALLQRTAKPDLPGR-VSFSKPNMHADLDSSDCDNDKQEVRPSISAPGPLTLPSFLS 234
            :.|...:.||:          |. |:....|.:|         ..::|.|..|:  ..|.||..:
  Rat   166 TANNRSNKGAV----------GNCVTTMVHNHYA---------SSKKVSPPKSS--NQTAPSLNN 209

  Fly   235 KVEQADPVGQKKSVHFGSTAAEGEVLAETYEYPKCPSENCTCSTRSSSTTST------NEASASD 293
            .|:.|              |.||   .|..::.| |.:|  .|:.|.||..|      .|.:..:
  Rat   210 IVKAA--------------AREG---GEGSDFGK-PRKN--FSSVSQSTRGTTGLLRRKEVTEEE 254

  Fly   294 VKCACDAPSCRFMESSKQVEPTSPTPTLPKAPSSELDVIREYKQAVEGVQVVKNHLGTDTLNNI- 357
            .:        ||::...|...|               :.|.|:     .||.:...|..:|.::
  Rat   255 AE--------RFIQQVNQAAVT---------------IQRWYR-----CQVQRRRTGAASLEHLL 291

  Fly   358 --------------EILPNYLDKYASPTKEKQNNLSETKNMA----TNSSAVNNGSVVYRPVGNP 404
                          .:|..:..:.|:..|.::....:.:..|    ....|.....|.:||
  Rat   292 ASKREGQRQRLGSGNLLDLHRQEEAARKKAREEKARQARQAAIQELQQKRAQKAREVEHRP---- 352

  Fly   405 RNFGAENNFLPAVQDDRRSFANGSSDGVINNYLKVASTPPFVGKKKENVKPASADPIARSSKSKV 469
                      |..:.:.|:.                          |..:|....|   |..|.|
  Rat   353 ----------PKERPETRAL--------------------------EQPRPTQEPP---SMPSSV 378

  Fly   470 TKSTINPA-----PLGKMKKAISVGSLREERKLSEYNLDKVDSWMSMQDQKQYDGKHKPGLEDLD 529
            |....|.|     |.|.............||                          :|.||  |
  Rat   379 THPKANNAGASLYPTGPADPCPPASESFPER--------------------------QPSLE--D 415

  Fly   530 EAQD--------NDTASQLSLKSNEDSRDSTYDEIVSVIKEIEEDK---------KRDNFSEGIP 577
            :.||        .|.|:..|.:|...:| :|.|:::..:|.:||:.         ::|.::....
  Rat   416 KPQDAHSQVEAREDLAALASTRSKTRAR-ATLDDLLDTLKLLEEEPEPLLHPKAYRQDRYAWMDE 479

  Fly   578 SELNLNLDSRCETADTVTVSEGKV------PESGD-----KYKDILAYLNNVESSCDKTLMETRR 631
            .|     |:...|||.:. ..||:      |:.|.     |.:.|:.:|:.:|.|..:.....|.
  Rat   480 EE-----DTNPLTADNLE-KFGKLSAAPGPPDDGTLLSEAKLQSIMTFLDEMEKSGQERPAPWRE 538

  Fly   632 SIPDSNRSEVEFVVEPDVTDEVPKLSELLMLPNHQLARRVIALSLRANELANAIHMSKEHVFQLR 696
            |:               |.:..|:..||    ..:....|:.|.|...|...|:.:.:..:.|.|
  Rat   539 SL---------------VLEAGPRSLEL----GSEGTTSVMRLKLELEEKKQAMVLLQRALAQQR 584

  Fly   697 GEKQKSLRAEKSTAAAKLRDQKKHYEEVVTRHQGFIEQLLKDKGSLCEKVAALTRRLESQNQAWE 761
            ....:.::..:...:.:||.||:.||..:.||..||:||::||..|.||..|:...|:..:|...
  Rat   585 DLATRRVKETEKELSRQLRQQKEQYEATIQRHLSFIDQLIEDKKVLSEKCEAVVAELKQGDQRCR 649

  Fly   762 HRL-------ETELARTKETTMAGEKIRRERWVRENTKKIKELTVKGLEAEINKMNCDHQREVTE 819
            .|:       |.|:.:.||...|.||||||:|:.|.||||||:||:|||.||.|:...|::||..
  Rat   650 ERVAQVQEQHELEIKKLKELMSATEKIRREKWINEKTKKIKEITVRGLEPEIQKLIAKHKQEVRR 714

  Fly   820 LKRTHQMQLLDALEEARTKHEQIETSIRESCAQDREAIIEKERTAIRERFERQLEEEQRTQAEQR 884
            |:..|:.:|....|:|..:|.:....:||...::|||:.::||...::|.|:.||:|||...:||
  Rat   715 LRGLHEAELQQREEQAAQRHLRQAEELREHLEREREALGQQERERAQQRLEQHLEQEQRALEQQR 779

  Fly   885 QKLTEEFAAERDRL-QSELRQRENEHQARRQEALREQEQELEQA-KFEMQERMAKQEEKYQNRVN 947
            ::|..|.|.|::|| |...|||....:.|:|  |.|....|.:| :.|.:....:||.::|..:.
  Rat   780 RRLYTEVAEEKERLGQQAARQRVELEELRQQ--LEESSAALTRALRAEFERSREEQERRHQMELK 842

  Fly   948 TIEQQYQADFELWKTEHENKTKLAQAEKENAIRQHYRAERDRQLDELVVRMEADALQHKEEHEL- 1011
            .::.|.:|:.:.|......|.:.....:|..:::..|..||::::.::.|:|||....|||.|.
  Rat   843 ALKDQLEAERQAWVASCAKKEEAWLLTRERELKEEIRKGRDQEIELVIHRLEADMTLAKEESERA 907

  Fly  1012 ---KMNRLKEKYEKDLVLAESVEKSLREKYAETRGKLAEADAQVRNSQAEVKQLQLELSH----S 1069
               ::.|:::|||.:|...|..|:.|:|:..|.:|:|.||:.:....|:.::|.:.||..    :
  Rat   908 AENRVKRVRDKYETELSELEQSERKLQERCTELKGRLGEAEGEKERLQSLLRQKEKELDDLRVVN 972

  Fly  1070 KKMCGD----IIMERDRLRDNLNAD------IQSELGVLNERHKQEMDQLQKRVHQTIQRQEETI 1124
            .:||.:    ..:.|....:.|.|.      :::||..|..|.:.|:|::.:||...:.|:|..:
  Rat   973 TQMCSERASLAQVVRQEFAEQLAASQEETQRVKAELAELRARQQMELDEVHRRVKTALARKEAAV 1037

  Fly  1125 EILKGDNDALRQQCLKLNAVIRQQR 1149
            ..|:..::|..::...|..::.|.:
  Rat  1038 NSLRKQHEAAEKRADHLEELLEQHK 1062

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dila	NP_001137629.2	FAM184	806..1024	CDD:292293	67/223 (30%)
		GBP_C	<826..938	CDD:303769	37/113 (33%)
		coiled coil	906..923	CDD:293879	4/16 (25%)
Cep131	NP_001101780.1	PHA03252	887..>948	CDD:223024	21/60 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354035
Domainoid	1	1.000	249	1.000	Domainoid score	I2057
eggNOG	1	0.900	-	-		E1_2CXTJ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	250	1.000	Inparanoid score	I3149
OMA	1	1.010	-	-		QHG50152
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008388
OrthoInspector	1	1.000	-	-		oto98536
orthoMCL	1	0.900	-	-		OOG6_104784
Panther	1	1.100	-	-	LDO	PTHR31540
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6376
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.760