Protein Alignment dila and CEP131

DIOPT Version :9

• Sequence 1: NP_001137629.2
• Gene: dila / 36010
• FlyBaseID: FBgn0033447
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: XP_011522849.1
• Gene: CEP131 / 22994
• HGNCID: 29511
• Length: 1088
• Species: Homo sapiens
• Alignment Length: 1148
• Identity: 272/1148 - (23%)
• Similarity: 482/1148 - (41%)
• Gaps: 218/1148 - (18%)

  Fly   137 DYSLHKRTPDSSEEGEQFLVNMPVGEKVKSYSSYSGNQGLSNGALLQRTAKPDLPGRVSFSKPNM 201
            |.||....|..|..........|:   |:|.|..:|::  ....:|:.|.    ||. |.:..|:
Human    19 DLSLTGLPPPVSRRPGSAATTKPI---VRSVSVVTGSE--QKRKVLEATG----PGG-SQAINNL 73

  Fly   202 HADLDSSDCDNDKQEVRPSISAPGPLTLPSFLSKVEQADPVGQKKSVHFGSTAAE---------- 256
            ...      ::..|..:|...:|.|.....||...| ..|.|:|:.....:..:|
Human    74 RRS------NSTTQVSQPRSGSPRPTEPTDFLMLFE-GSPSGKKRPASLSTAPSEKGATWNVLDD 131

  Fly   257 ---GEVL------AETYEYPKCP-SENCTCSTRSSSTTSTNEASASDVKCACDAPSCRFMESSKQ 311
               |..|      :...:.|..| .:.||.:...:.|.:......:...|.......|:..|.:.
Human   132 QPRGFTLPSNARSSSALDSPAGPRRKECTVALAPNFTANNRSNKGAVGNCVTTMVHNRYTPSERA 196

  Fly   312 VEPTSPTPTLP------KAPSSELDVIREYKQAVEGVQVVKNHLGTDTLNNIEILPNYLDKYASP 370
            ....|...|.|      ||.:.|                     |::: :....||.   ..:|.
Human   197 PPLKSSNQTAPSLNNIIKAATCE---------------------GSES-SGFGKLPK---NVSSA 236

  Fly   371 TKEKQNNLSETKNM-----ATNSSA------VNNGSVV----YRPVGNPRNFGAE--NNFLPAVQ 418
            |...:||...:..:     .|...|      ||..:|.    ||.....|..||.  .:.|.|.:
Human   237 THSARNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAKR 301

  Fly   419 DDRRSFANGSSDGVI--NNYLKVASTPPFVGKKKENVKPASADPIARSSKSKVTKST-------- 473
            :::|   ..|.:|.:  .:..|.|:......:|....:.|:...:.:....:..|::
Human   302 EEQR---QRSGEGTLLDLHQQKEAARRKAREEKARQARRAAIQELQQKRALRAQKASTAERGPPE 363

  Fly   474 ----------------INPAPLG---KMKKAISVGSLREERKLSEYNLDKVDSWMSMQDQKQYDG 519
                            ::|.|.|   :..||.:.|.........:..|...||  |.:.|:..:.
Human   364 NPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDS--SPEPQQPPED 426

  Fly   520 KHKPGLEDLDEAQDNDTASQLSLKSNEDSRDST-----YDEIVSVIKEIEEDKKRDNFSEGIP-- 577
            :.:..|.. |.|.||       |:....||.|.     .:|::..::.:|::      .:.:|
Human   427 RTQDVLAQ-DAAGDN-------LEMMAPSRGSAKSRGPLEELLHTLQLLEKE------PDVLPRP 477

  Fly   578 -----------SELNLNLDSRCETADTVTVSEGKV------PESGD-----KYKDILAYLNNVES 620
                       ||:....|:...|||.:. ..||:      ||.|.     |.:.|:::|:.:|.
Human   478 RTHHRGRYAWASEVTTEDDASSLTADNLE-KFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEK 541

  Fly   621 SCDKTLMETRRS-IPDSNRSEVEFVVEPDVTDEVPKLSELLMLPNHQLARRVIALSLRANELANA 684
            |....|...:.. :|::....:|.                    ..:::..|:.|.|...|...|
Human   542 SGQDQLDSQQEGWVPEAGPGPLEL--------------------GSEVSTSVMRLKLEVEEKKQA 586

  Fly   685 IHMSKEHVFQLRGEKQKSLRAEKSTAAAKLRDQKKHYEEVVTRHQGFIEQLLKDKGSLCEKVAAL 749
            :.:.:..:.|.|....:.::..:...:.:|:.|::|||..:.||..||:||::||..|.||..|:
Human   587 MLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAV 651

  Fly   750 TRRLESQNQAWEHRL-------ETELARTKETTMAGEKIRRERWVRENTKKIKELTVKGLEAEIN 807
            ...|:.::|....|:       |.|:.:.||...|.||.|||:|:.|.||||||:||:|||.||.
Human   652 VAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQ 716

  Fly   808 KMNCDHQREVTELKRTHQMQLLDALEEARTKHEQIETSIRESCAQDREAIIEKERTAIRERFERQ 872
            |:...|::||..||..|:.:||.:.|.|..:..:....:||...:::||:.::||...|:||::.
Human   717 KLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRFQQH 781

  Fly   873 LEEEQRTQAEQRQKLTEEFAAERDRL-QSELRQRENEHQARRQEALREQEQELEQA-KFEMQERM 935
            ||:||....:|||:|..|.|.||:|| |...|||....:.|:|  |.|....|.:| :.|.::..
Human   782 LEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQ--LEESSSALTRALRAEFEKGR 844

  Fly   936 AKQEEKYQNRVNTIEQQYQADFELWKTEHENKTKLAQAE-----KENAIRQHYRAERDRQLDELV 995
            .:||.::|..:||::||.:.:.:.|:.....|.:::..|     :|..:|:..|..||::::.::
Human   845 EEQERRHQMELNTLKQQLELERQAWEAGRTRKERMSPQEAWLLNREQELREEIRKGRDKEIELVI 909

  Fly   996 VRMEADALQHKEEH----ELKMNRLKEKYEKDLVLAESVEKSLREKYAETRGKLAEADAQVRNSQ 1056
            .|:|||....|||.    |.::.||::|||.:|...|..|:.|:|:.:|.:|:|.||:.:....|
Human   910 HRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQ 974

  Fly  1057 AEVKQLQLELSHSKKMCGDIIMERDRL--------RDNLNA------DIQSELGVLNERHKQEMD 1107
            ..|:|.:..|..::.:...:..||..|        .|.|.|      ..::||..|..|.:.|::
Human   975 GLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELE 1039

  Fly  1108 QLQKRVHQTIQRQEETIEILKGDNDALRQQCLKLNAVIRQQRK 1150
            ::.:||...:.|:||.:..|:..::|..::...|..::.|.|:
Human  1040 EVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQHRR 1082

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dila	NP_001137629.2	FAM184	806..1024	CDD:292293	74/228 (32%)
		GBP_C	<826..938	CDD:303769	38/113 (34%)
		coiled coil	906..923	CDD:293879	4/16 (25%)
CEP131	XP_011522849.1	GBP_C	<799..907	CDD:303769	32/109 (29%)
		coiled coil	885..896	CDD:293879	2/10 (20%)
		PHA03252	906..>1017	CDD:223024	33/110 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159967
Domainoid	1	1.000	257	1.000	Domainoid score	I2022
eggNOG	1	0.900	-	-		E1_2CXTJ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	258	1.000	Inparanoid score	I3151
Isobase	1	0.950	-	0	Normalized mean entropy	S6728
OMA	1	1.010	-	-		QHG50152
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008388
OrthoInspector	1	1.000	-	-		oto91457
orthoMCL	1	0.900	-	-		OOG6_104784
Panther	1	1.100	-	-	LDO	PTHR31540
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6376
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.710