Protein Alignment dila and Cep131

DIOPT Version :10

• Sequence 1: NP_001137629.2
• Gene: dila / 36010
• FlyBaseID: FBgn0033447
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_033864.3
• Gene: Cep131 / 12009
• MGIID: 107440
• Length: 1059
• Species: Mus musculus
• Alignment Length: 1223
• Identity: 289/1223 - (23%)
• Similarity: 486/1223 - (39%)
• Gaps: 299/1223 - (24%)

  Fly    41 PKYTSRSLTTLHNPCPHFRPRSANFLQQRSRSSPFLGRPQSADPKFGRRLSNYFVEKELR---NG 102
            |:....||..|..|... ||.||:..:...||   :.....::|:          :|.|.   .|
Mouse    15 PEAVDLSLIGLPPPMSQ-RPGSASATRSIFRS---MSVATGSEPR----------KKALEATGPG 65

  Fly   103 GKRQVSSNDLLKSLLEEPIKRSWLCRSTCNSSESDYSLHKRTPDSSEEGEQFLVNMPVGEKVKSY 167
            |.|.:  |:|.:|.....:.:||                ..:|..:|..: ||:..
Mouse    66 GPRAI--NNLRRSNSTTQVNQSW----------------TGSPRPAEPTD-FLMLF--------- 102

  Fly   168 SSYSGNQGLSNGALLQRTAKPDLPGRVSFSKPNMHADLDSSDCDNDKQEVRPSISAPGPLTLPSF 232
                  :|.::|.  :|.|        |.||.:...:...:..|...:.:....||..|.||.|.
Mouse   103 ------EGSTSGR--RRVA--------SLSKASSEKEATWNVLDEQPRGLALPASAQSPSTLDSA 151

  Fly   233 LSKVEQADPVGQKKSVHFGSTAAEGEVLAETYEYPKCPSENCTCSTRSSS-------TTSTNEAS 290
            |         |.::.                 |.|..||  .|.:.||:.       ||..:...
Mouse   152 L---------GPRRK-----------------ECPLAPS--FTANNRSNKGAVGNCVTTMVHNHY 188

  Fly   291 ASDVKCACDAPSCRFMESSKQVEPTSPTPTLPKAPSSELDVIREYKQAVEGVQVVKNHLGTDTLN 355
            |                |||.|.|  |..:...|||....|....::..||..:.|
Mouse   189 A----------------SSKMVSP--PKSSNQTAPSLNNIVKAAAREGGEGSDLGK--------- 226

  Fly   356 NIEILPNYLDKYASPTKEKQNNLSETKNMATNSSA------------------VNNGSVV----Y 398
                          |.|    |||.....|..::.                  ||..:|.    |
Mouse   227 --------------PRK----NLSSASQSARGTTGLLRRREVTEEEAERFIHQVNQAAVTIQRWY 273

  Fly   399 RPVGNPRNFGAE--NNFLPAVQDDRRSFANGSSDGVINNYLKVASTPPFVGKKKENVKPASADPI 461
            |.....|..||.  .:.|.:.::.:|....|      .|.|::........||....|...|...
Mouse   274 RCQVQRRRAGAAALEHLLASKREGQRQRLGG------GNLLELHRQEEAARKKAREEKARQARQA 332

  Fly   462 ARSSKSK-----------------VTKSTINPAPLGK-----MKKAISVGSLREERKLSEYNLDK 504
            |...:.|                 .|::...|.|:.:     ..||.:.|:       |.|....
Mouse   333 AIQEQQKRAQKASEAEHRRPKDRPETRAPEQPRPMQEPGCVTHPKANNAGA-------SIYPTGP 390

  Fly   505 VD-----------SWMSMQDQKQYDGKHKPGLEDLDEAQDNDTASQLSLKSNEDSRDSTYDEIVS 558
            .|           .|.|.:|:.|  ..|..|     ||: .|.|...|.:....:| :|.|:::.
Mouse   391 ADPCPPASESSPEQWQSPEDKPQ--DIHSQG-----EAR-QDLAVSGSSRGKARAR-ATLDDLLD 446

  Fly   559 VIKEIEEDKK---------RDNFSEGIPSELNLNLDSRCETADTVTVSEGKV------PESGD-- 606
            .:|.:||:.:         :|.::.....|     |:...|||.:. ..||:      |:.|.
Mouse   447 TLKLLEEEPEPLPHPKAYHKDRYAWTDEEE-----DANSLTADNLE-KFGKLSAAPGPPDDGTLL 505

  Fly   607 ---KYKDILAYLNNVESSCDKTLMETRRSIPDSNRSEVEFVVEPDVTDEVPKLSELLMLPNHQLA 668
               |.:.|:.:|:.:|.|..:.....|.|:          |:|.....|.              :
Mouse   506 SEAKLQSIMTFLDEMEKSGQERPAPWRESL----------VLEAGSGSEG--------------S 546

  Fly   669 RRVIALSLRANELANAIHMSKEHVFQLRGEKQKSLRAEKSTAAAKLRDQKKHYEEVVTRHQGFIE 733
            ..|:.|.|...|...|:.:.:..:.|.|....:.::..:.....:||.||:.||..:.||..||:
Mouse   547 TSVMRLKLELEEKKQAMALLQRALAQQRDLTVRRVKETEKELTRQLRQQKEQYEATIQRHLSFID 611

  Fly   734 QLLKDKGSLCEKVAALTRRLESQNQAWEHRL-------ETELARTKETTMAGEKIRRERWVRENT 791
            ||::||..|.||..|:...|:..:|....|:       |.|:.:.||...|.||||||:|:.|.|
Mouse   612 QLIEDKKVLSEKCEAVVAELKHGDQRCRERVAQMQEQHELEIKKLKELMSATEKIRREKWINEKT 676

  Fly   792 KKIKELTVKGLEAEINKMNCDHQREVTELKRTHQMQLLDALEEARTKHEQIETSIRESCAQDREA 856
            |||||:||:|||.||.|:...|::||..|:..|:.:|....|:|..:|.:....:|:...::||.
Mouse   677 KKIKEITVRGLEPEIQKLIAKHKQEVRRLRGLHEAELQQREEQAAQRHLRQAEELRQHLDREREV 741

  Fly   857 IIEKERTAIRERFERQLEEEQRTQAEQRQKLTEEFAAERDRL-QSELRQRENEHQARRQEALREQ 920
            :.::||...::|||:.||:|||...:||::|..|.|.|::|| |...|||....:.|:|  |.|.
Mouse   742 LGQQERERAQQRFEQHLEQEQRALEQQRRRLYNEVAEEKERLGQQAARQRAELEELRQQ--LEES 804

  Fly   921 EQELEQA-KFEMQERMAKQEEKYQNRVNTIEQQYQADFELWKTEHENKTKLAQAEKENAIRQHYR 984
            ...|.:| :.|.:....:||.::|..:..::.|.:|:.:.|......|.:.....:|..:::..|
Mouse   805 SAALTRALRAEFERSREEQERRHQMELKALKDQLEAERQAWVASCAKKEEAWLLTRERELKEEIR 869

  Fly   985 AERDRQLDELVVRMEADALQHKEEH----ELKMNRLKEKYEKDLVLAESVEKSLREKYAETRGKL 1045
            ..||::::.::.|:|||....|||.    |.::.|:::|||.:|...|..|:.|:|:.:|.:|:|
Mouse   870 KGRDQEIELVIHRLEADMTLAKEESERAAESRVKRVRDKYETELSELEQSERKLQERCSELKGRL 934

  Fly  1046 AEADAQVRNSQAEVKQLQLELSH----SKKMCGD----IIMERDRLRDNLNAD------IQSELG 1096
            .||:.:....|:.|:|.:.||..    :.:||.:    ..:.|....:.|.|.      ::.||.
Mouse   935 GEAEGEKERLQSLVRQKEKELEDLRAVNTQMCSERASLAQVVRQEFAEQLAASQEETQRVKVELA 999

  Fly  1097 VLNERHKQEMDQLQKRVHQTIQRQEETIEILKGDNDALRQQCLKLNAVIRQQR 1149
            .|..|.:.|:|::.:||...:.|:|..:..|:..::|..::...|..::.|.:
Mouse  1000 ELQARQQVELDEVHRRVKTALARKEAAVNSLRKQHEAAVKRADHLEELLEQHK 1052

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dila	NP_001137629.2	EnvC	700..>941	CDD:443969	91/249 (37%)
		Smc	<827..>1066	CDD:440809	72/244 (30%)
		GumC	<999..>1150	CDD:442439	45/169 (27%)
Cep131	NP_033864.3	Interaction with PLK4. /evidence=ECO:0000250|UniProtKB:Q9UPN4	1..244		71/359 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..96		24/112 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	136..155		8/27 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	217..248		9/57 (16%)
		PTZ00449	<326..>409	CDD:185628	14/89 (16%)
		Smc	<552..>1050	CDD:440809	151/499 (30%)