DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1698 and Slc6a2

DIOPT Version :9

Sequence 1:	NP_001260835.1	Gene:	CG1698 / 36006	FlyBaseID:	FBgn0033443	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_112633.2	Gene:	Slc6a2 / 83511	RGDID:	621822	Length:	617	Species:	Rattus norvegicus

Alignment Length:	573	Identity:	214/573 - (37%)
Similarity:	315/573 - (54%)	Gaps:	42/573 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 SGVE---AGQPG--KKRDSWNNDIEFLMSCIALSVGLGNVWRFPFTALENGGGAFVIPYLIVLIL 122
            :||:   |.|.|  :.|::|...|:||:|.:..:|.|.||||||:...:||||||:|||.:.||:
  Rat    40 NGVQCLLASQDGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLII 104

  Fly   123 VGKPVYYLEMLLGQFSSRGSVKVYDFSPIMRGIGYGQVLATGIVTTYYATLMALTLRYFVDSFYP 187
            .|.|::|:|:.||||:..|:..|:...|..:|:||..:|....|..||..::|.:|.|...||..
  Rat   105 AGMPLFYMELALGQFNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTL 169

  Fly   188 TLPWSYCREEWGT-ECLDSGPQEASRATSLAGSGVR------TTSAEFYFTNII-LREKASIDDG 244
            .|||:.|...|.: .|.|.....|    |:.|...:      |.:||||...:: |.|.:.|.|
  Rat   170 NLPWTNCGHAWNSPNCTDPKLLNA----SVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHD- 229

  Fly   245 IGYPSWSLALALAVAWIVIAGIMFKGVKSSGKASYFLALFPYVVMLVLLVRALTLPGAFDGVLYF 309
            ||.|.|.|.|.|.|..:|:...::||||:|||..:..|..||.|:.||||..:|||||.:|:..:
  Rat   230 IGLPQWQLLLCLMVVIVVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAY 294

  Fly   310 LRPQWHKLLEPQVWYAAVTQVFFSLAICFGNIIMYASYNRFGHNIYRDANIVTTLDTFTSLLSGV 374
            |...:::|.|..||..|.||:||||...||.:|.:||||:|.:|.||||.:.:|::..||.:||.
  Rat   295 LHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGF 359

  Fly   375 IIFGILGNLAYENNTTDIASVVNGGPGLAFISYPDAIAKFK----WLPQLFSVLFFLMLFVLGIG 435
            .||.|||.:|:|:. ..|..|...|.||.|:.||:||:...    |     :|||||||..||:.
  Rat   360 AIFSILGYMAHEHK-VKIEDVATEGAGLVFVLYPEAISTLSGSTFW-----AVLFFLMLLALGLD 418

  Fly   436 SNVGMASCMSTVIKDQF----GHLKNWTVVVGIAIVGYFLGLLYITPGGQFLLNLVDYFGVTFVA 496
            |::|....:.|.:.|.|    .|.|.:|..|.:..  :.|.:..||.||.::|.|:|.|......
  Rat   419 SSMGGMEAVITGLADDFQVLKRHRKLFTCAVTLGT--FLLAMFCITKGGIYVLTLLDTFAAGTSI 481

  Fly   497 LVLAIFELVTIAWIYGVKRLCRDVEFMIGIKTSLYYRICWAVVTPLLMLTILIYTLVLYEPLKYK 561
            |...:.|.:.::|.|||.|...|::.|:|.|..||:|:||..|:|..:|.:::.:::.::||.|.
  Rat   482 LFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYD 546

  Fly   562 DYTYQSGVYVFGWCLSAFGVGQVLFWAIPA--VRKQPSHLG-LWARIRKAFEP 611
            ||.|.......||     |:.......:||  :.|..|..| ||.|:.....|
  Rat   547 DYVYPPWANWVGW-----GIALSSMILVPAYVIYKFFSIRGSLWERVAYGITP 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1698	NP_001260835.1	SLC6sbd	75..552	CDD:271359	190/492 (39%)
Slc6a2	NP_112633.2	SLC5-6-like_sbd	56..615	CDD:382020	209/557 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820