DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1698 and Slc6a1

DIOPT Version :9

Sequence 1:	NP_001260835.1	Gene:	CG1698 / 36006	FlyBaseID:	FBgn0033443	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_077347.1	Gene:	Slc6a1 / 79212	RGDID:	620533	Length:	599	Species:	Rattus norvegicus

Alignment Length:	584	Identity:	199/584 - (34%)
Similarity:	323/584 - (55%)	Gaps:	55/584 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 GDSPSGVEAGQPGKKRDSWNNDIEFLMSCIALSVGLGNVWRFPFTALENGGGAFVIPYLIVLILV 123
            ||.|.          ||:|....:|||||:..::|||||||||:...:||||||:|||.:.||..
  Rat    39 GDLPD----------RDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFA 93

  Fly   124 GKPVYYLEMLLGQFSSRGSVKVYDFSPIMRGIGYGQVLATGIVTTYYATLMALTLRYFVDSFYPT 188
            |.|::.||..|||::|.|.:.|:..:|:.:|:|....:.:..:..||..:::..:.|..:||..|
  Rat    94 GVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTT 158

  Fly   189 LPWSYCREEWGTE-CLDSGPQEASRATSLAGSGVRTTSA--EFYFTNIILREKASIDDGIGYPS- 249
            |||..|...|.|: |..:        .||..: ...|||  ||:..|:     ..:.||:..|.
  Rat   159 LPWKQCDNPWNTDRCFSN--------YSLVNT-TNMTSAVVEFWERNM-----HQMTDGLDKPGQ 209

  Fly   250 --WSLALALAVAWIVIAGIMFKGVKSSGKASYFLALFPYVVMLVLLVRALTLPGAFDGVLYFLRP 312
              |.||:.||:||:::...::|||..:||..||.|.:||:::::|..|.:|||||.:|:|:::.|
  Rat   210 IRWPLAITLAIAWVLVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITP 274

  Fly   313 QWHKLLEPQVWYAAVTQVFFSLAICFGNIIMYASYNRFGHNIYRDANIVTTLDTFTSLLSGVIIF 377
            .:.||.:.:||..|.||:|||..:..|::|...|||.|.:|:|||:.||..:::.||:.:|.:||
  Rat   275 NFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIF 339

  Fly   378 GILGNLAYENNTTDIASVVNGGPGLAFISYPDAIAKFKWLPQLFSVLFFLMLFVLGIGSNVGMAS 442
            .|:|.:|:....: ||.|...||||||::||:|:.:....| |:::|||.||.:|||.|......
  Rat   340 SIVGFMAHVTKRS-IADVAASGPGLAFLAYPEAVTQLPISP-LWAILFFSMLLMLGIDSQFCTVE 402

  Fly   443 CMSTVIKDQFGHL---KNWTVVVGIAIVGYFLGLLYITPGGQFLLNLVDYFGVTFVALV-LAIFE 503
            ...|.:.|::..|   :....:..:.||.|.:||..||.||.::..|.||:..:.::|: |..||
  Rat   403 GFITALVDEYPRLLRNRRELFIAAVCIVSYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFE 467

  Fly   504 LVTIAWIYGVKRLCRDVEFMIGIKTSLYYRICWAVVTPLLMLTILIYTLVLYEPLKYKDYTYQSG 568
            .|:|:|.|||.|...:::.|:|.:..:::::||:..||:::..:.:::.|...||....|.:...
  Rat   468 CVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFLFSAVQMTPLTMGSYVFPKW 532

  Fly   569 VYVFGW--CLSAF----GVGQVLFWAIPAVRKQPSHLGLWARIRKAFEP-----LPNWGPSDPQ 621
            ....||  .||:.    |....:|..:....||        |::...:|     .|..||..||
  Rat   533 GQGVGWLMALSSMVLIPGYMAYMFLTLKGSLKQ--------RLQVMIQPSEDIVRPENGPEQPQ 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1698	NP_001260835.1	SLC6sbd	75..552	CDD:271359	176/486 (36%)
Slc6a1	NP_077347.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		SLC6sbd_GAT1	2..599	CDD:212075	199/584 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..599		5/12 (42%)
		PDZ-binding	597..599
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820