DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1698 and SLC6A13

DIOPT Version :9

Sequence 1:	NP_001260835.1	Gene:	CG1698 / 36006	FlyBaseID:	FBgn0033443	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_057699.2	Gene:	SLC6A13 / 6540	HGNCID:	11046	Length:	602	Species:	Homo sapiens

Alignment Length:	572	Identity:	214/572 - (37%)
Similarity:	317/572 - (55%)	Gaps:	37/572 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 KRDSWNNDIEFLMSCIALSVGLGNVWRFPFTALENGGGAFVIPYLIVLILVGKPVYYLEMLLGQF 137
            :|..|||.:||::|.....:|||||||||:...:||||||.||||:.|...|.||:.||..|||:
Human    31 ERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTCGIPVFLLETALGQY 95

  Fly   138 SSRGSVKVY-DFSPIMRGIGYGQVLATGIVTTYYATLMALTLRYFVDSFYPTLPWSYCREEWGTE 201
            :|:|.|..: ...||..||||...:...::..||..::|..|.|...||...|||..|..||.||
Human    96 TSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLFSSFTIDLPWGGCYHEWNTE 160

  Fly   202 -CLDSGPQEASRATSLAGSGVRTTS--AEFYFTNIILREKASIDDGI---GYPSWSLALALAVAW 260
             |::......    ||.|:....||  .||:...::     .|.|||   |...|.|||.|.:||
Human   161 HCMEFQKTNG----SLNGTSENATSPVIEFWERRVL-----KISDGIQHLGALRWELALCLLLAW 216

  Fly   261 IVIAGIMFKGVKSSGKASYFLALFPYVVMLVLLVRALTLPGAFDGVLYFLRPQWHKLLEPQVWYA 325
            ::....::|||||:||..||.|.|||::::|||:|.:|||||..|:.::|.|...:|.:||||..
Human   217 VICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMD 281

  Fly   326 AVTQVFFSLAICFGNIIMYASYNRFGHNIYRDANIVTTLDTFTSLLSGVIIFGILGNLAYENNTT 390
            |.||:|||.|||.|.:....|||::.:|.|||...:..|::.||.::|..||.|||.::.|.. .
Human   282 AGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSGTSFVAGFAIFSILGFMSQEQG-V 345

  Fly   391 DIASVVNGGPGLAFISYPDAIAKFKWLPQLFSVLFFLMLFVLGIGSNVGMASCMSTVIKDQFGHL 455
            .|:.|...|||||||:||.|:....:.| |::..||.|:.:||:.|.......:.|.:.|.:.|:
Human   346 PISEVAESGPGLAFIAYPRAVVMLPFSP-LWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPHV 409

  Fly   456 -----KNWTVVVGIAIVGYFLGLLYITPGGQFLLNLVDYFGVTFVALV-LAIFELVTIAWIYGVK 514
                 :...:::|:::|.:.:||:.:|.||.::..|.||:..:.:.|: :||||.:.:||:||.|
Human   410 FRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAK 474

  Fly   515 RLCRDVEFMIGIKTSLYYRICWAVVTPLLMLTILIYTLVLYEPLKY-KDYTYQSGVYVFGWCLSA 578
            |...::|.|||.:.....:.||..:||.:.....:::|:.|.||.| |.|||.......||.|:.
Human   475 RFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLAL 539

  Fly   579 FGVGQVLFWAI--PAVRKQPSHLGLWARIRKAF---EPLPN---WGPSDPQT 622
            ..:..:..|::  ....|.|..    .|||:..   |.||.   .|||.|.|
Human   540 SSMVCIPAWSLYRLGTLKGPFR----ERIRQLMCPAEDLPQRNPAGPSAPAT 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1698	NP_001260835.1	SLC6sbd	75..552	CDD:271359	187/489 (38%)
SLC6A13	NP_057699.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
SLC6A13	NP_057699.2	SLC6sbd_GAT2	32..575	CDD:271396	207/557 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820