DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1698 and SLC6A6

DIOPT Version :9

Sequence 1:	NP_001260835.1	Gene:	CG1698 / 36006	FlyBaseID:	FBgn0033443	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_001127839.2	Gene:	SLC6A6 / 6533	HGNCID:	11052	Length:	721	Species:	Homo sapiens

Alignment Length:	548	Identity:	214/548 - (39%)
Similarity:	311/548 - (56%)	Gaps:	25/548 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 KKTLSEGSGSAPPPGHGDSPSGVEAGQPGKKRDSWNNDIEFLMSCIALSVGLGNVWRFPFTALEN 107
            |..|....|.:|    |..|.....|:| .:|:.|::.|:|::|.....||||||||||:...:|
Human   116 KDILKPSPGKSP----GTRPEDEAEGKP-PQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKN 175

  Fly   108 GGGAFVIPYLIVLILVGKPVYYLEMLLGQFSSRGSVKVYD-FSPIMRGIGYGQVLATGIVTTYYA 171
            |||||:|||.|.|...|.||::||:::||::|.|.:..:: ..|:..||||..|:...::..||.
Human   176 GGGAFLIPYFIFLFGSGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYI 240

  Fly   172 TLMALTLRYFVDSFYPTLPWSYCREEWGT-ECL-DSGPQEASRATSLAGSGVRTTSAEFYFTNII 234
            .::|....|...||...|||::|...|.| .|: |:..:..|...:::.:...:...||:..|::
Human   241 VILAWATYYLFQSFQKELPWAHCNHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVL 305

  Fly   235 LREKASIDDGIGYP---SWSLALALAVAWIVIAGIMFKGVKSSGKASYFLALFPYVVMLVLLVRA 296
                 |:..||.:|   .|.|||.|.:.|:|....::|||:|:||..||.|.||:.::||||||.
Human   306 -----SLSPGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRG 365

  Fly   297 LTLPGAFDGVLYFLRPQWHKLLEPQVWYAAVTQVFFSLAICFGNIIMYASYNRFGHNIYRDANIV 361
            ||||||..|:.::|.|...:|.:||||..|.||:|||.|||.|.:....|||::.:|.|||..::
Human   366 LTLPGAGAGIKFYLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLL 430

  Fly   362 TTLDTFTSLLSGVIIFGILGNLAYENNTTDIASVVNGGPGLAFISYPDAIAKFKWLPQLFSVLFF 426
            ..|::.||.:||..||.|||.:|.|.. .|||.|...|||||||:||.|:.... ||..:|:|||
Human   431 GCLNSGTSFVSGFAIFSILGFMAQEQG-VDIADVAESGPGLAFIAYPKAVTMMP-LPTFWSILFF 493

  Fly   427 LMLFVLGIGSNVGMASCMSTVIKDQFGHL--KNWTVVVGIAIV---GYFLGLLYITPGGQFLLNL 486
            :||.:||:.|.........|.:.|.:...  |.:...:.||.|   .|.|||..:|.||.::..|
Human   494 IMLLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQL 558

  Fly   487 VDYFGVTFVALV-LAIFELVTIAWIYGVKRLCRDVEFMIGIKTSLYYRICWAVVTPLLMLTILIY 550
            .||:..:.|.|: :|.||...||||||...|...:|.|||.:...:.:..|||:||:|.:...|:
Human   559 FDYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIF 623

  Fly   551 TLVLYEPLKY-KDYTYQSGVYVFGWCLS 577
            :||.|.||.| |.|.|.:.....||.|:
Human   624 SLVKYVPLTYNKTYVYPNWAIGLGWSLA 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1698	NP_001260835.1	SLC6sbd	75..552	CDD:271359	193/488 (40%)
SLC6A6	NP_001127839.2	SLC6sbd_TauT	142..683	CDD:271398	206/517 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820