Protein Alignment CG1698 and SLC6A6

DIOPT Version :10

• Sequence 1: NP_610517.1
• Gene: CG1698 / 36006
• FlyBaseID: FBgn0033443
• Length: 654
• Species: Drosophila melanogaster
• Sequence 2: NP_001127839.2
• Gene: SLC6A6 / 6533
• HGNCID: 11052
• Length: 721
• Species: Homo sapiens
• Alignment Length: 539
• Identity: 213/539 - (39%)
• Similarity: 309/539 - (57%)
• Gaps: 23/539 - (4%)

  Fly    54 PPPGH--GDSPSGVEAGQPGKKRDSWNNDIEFLMSCIALSVGLGNVWRFPFTALENGGGAFVIPY 116
            |.||.  |..|.....|:| .:|:.|::.|:|::|.....||||||||||:...:||||||:|||
Human   121 PSPGKSPGTRPEDEAEGKP-PQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPY 184

  Fly   117 LIVLILVGKPVYYLEMLLGQFSSRGSVKVYD-FSPIMRGIGYGQVLATGIVTTYYATLMALTLRY 180
            .|.|...|.||::||:::||::|.|.:..:: ..|:..||||..|:...::..||..::|....|
Human   185 FIFLFGSGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYY 249

  Fly   181 FVDSFYPTLPWSYCREEWGT-ECL-DSGPQEASRATSLAGSGVRTTSAEFYFTNIILREKASIDD 243
            ...||...|||::|...|.| .|: |:..:..|...:::.:...:...||:..|::     |:..
Human   250 LFQSFQKELPWAHCNHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVL-----SLSP 309

  Fly   244 GIGYP---SWSLALALAVAWIVIAGIMFKGVKSSGKASYFLALFPYVVMLVLLVRALTLPGAFDG 305
            ||.:|   .|.|||.|.:.|:|....::|||:|:||..||.|.||:.::||||||.||||||..|
Human   310 GIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGAG 374

  Fly   306 VLYFLRPQWHKLLEPQVWYAAVTQVFFSLAICFGNIIMYASYNRFGHNIYRDANIVTTLDTFTSL 370
            :.::|.|...:|.:||||..|.||:|||.|||.|.:....|||::.:|.|||..::..|::.||.
Human   375 IKFYLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSF 439

  Fly   371 LSGVIIFGILGNLAYENNTTDIASVVNGGPGLAFISYPDAIAKFKWLPQLFSVLFFLMLFVLGIG 435
            :||..||.|||.:|.|.. .|||.|...|||||||:||.|:.... ||..:|:|||:||.:||:.
Human   440 VSGFAIFSILGFMAQEQG-VDIADVAESGPGLAFIAYPKAVTMMP-LPTFWSILFFIMLLLLGLD 502

  Fly   436 SNVGMASCMSTVIKDQFGHL--KNWTVVVGIAIV---GYFLGLLYITPGGQFLLNLVDYFGVTFV 495
            |.........|.:.|.:...  |.:...:.||.|   .|.|||..:|.||.::..|.||:..:.|
Human   503 SQFVEVEGQITSLVDLYPSFLRKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGV 567

  Fly   496 ALV-LAIFELVTIAWIYGVKRLCRDVEFMIGIKTSLYYRICWAVVTPLLMLTILIYTLVLYEPLK 559
            .|: :|.||...||||||...|...:|.|||.:...:.:..|||:||:|.:...|::||.|.||.
Human   568 CLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIFSLVKYVPLT 632

  Fly   560 Y-KDYTYQSGVYVFGWCLS 577
            | |.|.|.:.....||.|:
Human   633 YNKTYVYPNWAIGLGWSLA 651

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1698	NP_610517.1	SLC6sbd	75..552	CDD:271359	193/488 (40%)
SLC6A6	NP_001127839.2	SLC6sbd_TauT	142..683	CDD:271398	206/517 (40%)