Protein Alignment CG1698 and SLC6A4

DIOPT Version :9

• Sequence 1: NP_001260835.1
• Gene: CG1698 / 36006
• FlyBaseID: FBgn0033443
• Length: 654
• Species: Drosophila melanogaster
• Sequence 2: NP_001036.1
• Gene: SLC6A4 / 6532
• HGNCID: 11050
• Length: 630
• Species: Homo sapiens
• Alignment Length: 623
• Identity: 214/623 - (34%)
• Similarity: 340/623 - (54%)
• Gaps: 66/623 - (10%)

  Fly     1 METTINNNN------------NDNGYMNQAYVGSLNASTISIPGAYKPNESSNGKKTLSEGSGSA 53
            ||||..|:.            .:||.:.:         .:..||    ::..:|:  :|.|..:.
Human     1 METTPLNSQKQLSACEDGEDCQENGVLQK---------VVPTPG----DKVESGQ--ISNGYSAV 50

  Fly    54 PPPGHGD--------SPSGVEAGQPGKKRDSWNNDIEFLMSCIALSVGLGNVWRFPFTALENGGG 110
            |.||.||        :.:.:.|.....:|::|...::||:|.|..:|.||||||||:...:||||
Human    51 PSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGG 115

  Fly   111 AFVIPYLIVLILVGKPVYYLEMLLGQFSSRGSVKVY-DFSPIMRGIGYGQVLATGIVTTYYATLM 174
            ||::||.|:.|..|.|::|:|:.|||:...|.:.:: ...||.:||||...:....:.:||.|:|
Human   116 AFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIM 180

  Fly   175 ALTLRYFVDSFYPTLPWSYCREEWGT-ECLDSGPQEASRATSLAGSGVRTTSAEFYFTNIIL--- 235
            |..|.|.:.||...|||:.|:..|.| .|.:...::     ::..:...|:.||.::|..:|
Human   181 AWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSED-----NITWTLHSTSPAEEFYTRHVLQIH 240

  Fly   236 REKASIDDGIGYPSWSLALALAVAWIVIAGIMFKGVKSSGKASYFLALFPYVVMLVLLVRALTLP 300
            |.|...|  :|..||.|||.:.:.:.||...::||||:|||..:..|.|||:::.|||||..|||
Human   241 RSKGLQD--LGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLP 303

  Fly   301 GAFDGVLYFLRPQWHKLLEPQVWYAAVTQVFFSLAICFGNIIMYASYNRFGHNIYRDANIVTTLD 365
            ||:.|||::|:|.|.||||..||..|..|:||||...||.::.:||||:|.:|.|:||.:.:.::
Human   304 GAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVN 368

  Fly   366 TFTSLLSGVIIFGILGNLAYENNTTDIASVV-NGGPGLAFISYPDAIAKFKWLP--QLFSVLFFL 427
            ..||.:||.:||.:||.:| |....|::.|. :.||.|.||:|.:|||.   :|  ..|:::|||
Human   369 CMTSFVSGFVIFTVLGYMA-EMRNEDVSEVAKDAGPSLLFITYAEAIAN---MPASTFFAIIFFL 429

  Fly   428 MLFVLGIGSNVGMASCMSTVIKDQFGHLKNWT-----VVVGIAIVGYFLGLLYITPGGQFLLNLV 487
            ||..||:.|.......:.|.:.|:|.|:  |.     .|:.:.|..:|..|:.:|.||.:::.|:
Human   430 MLITLGLDSTFAGLEGVITAVLDEFPHV--WAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLL 492

  Fly   488 DYFGVTFVALVLAIFELVTIAWIYGVKRLCRDVEFMIGIKTSLYYRICWAVVTPLLMLTILIYTL 552
            :.:......|.:|:.|.|.::|.||:.:.||||:.|:|.....::||||..::||.:|.|:...|
Human   493 EEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFL 557

  Fly   553 VLYEPLKYKDYTYQSGVYVFGWCLSAFGVGQVLFWAIP 590
            :....|:...|.|.....:.|:|     :|...|..||
Human   558 MSPPQLRLFQYNYPYWSIILGYC-----IGTSSFICIP 590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1698	NP_001260835.1	SLC6sbd	75..552	CDD:271359	185/489 (38%)
SLC6A4	NP_001036.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..59		17/72 (24%)
		5HT_transport_N	24..64	CDD:397524	12/54 (22%)
		SLC6sbd_SERT	79..615	CDD:271399	196/530 (37%)
		Interaction with RAB4A	616..624

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920