DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1698 and SLC6A3

DIOPT Version :9

Sequence 1:	NP_001260835.1	Gene:	CG1698 / 36006	FlyBaseID:	FBgn0033443	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_001035.1	Gene:	SLC6A3 / 6531	HGNCID:	11049	Length:	620	Species:	Homo sapiens

Alignment Length:	572	Identity:	202/572 - (35%)
Similarity:	321/572 - (56%)	Gaps:	30/572 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 PGAYKPNE-------SSNGKKTLSEGSGSAPPPGHGDSPSGVEAGQPGKKRDSWNNDIEFLMSCI 88
            |.|..|.|       ..||.: |:..:.:.|      ..|.|||    :.|::|...|:||:|.|
Human    21 PNAVGPKEVELILVKEQNGVQ-LTSSTLTNP------RQSPVEA----QDRETWGKKIDFLLSVI 74

  Fly    89 ALSVGLGNVWRFPFTALENGGGAFVIPYLIVLILVGKPVYYLEMLLGQFSSRGSVKVYDFSPIMR 153
            ..:|.|.||||||:...:||||||::|||:.:::.|.|::|:|:.||||:..|:..|:...||::
Human    75 GFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPILK 139

  Fly   154 GIGYGQVLATGIVTTYYATLMALTLRYFVDSFYPTLPWSYCREEWGT-ECLDSGPQEASRATSLA 217
            |:|:..:|.:..|..:|..::|..|.|...||...|||.:|...|.: .|.|:.|.::|..:|..
Human   140 GVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDSSGDSSGL 204

  Fly   218 GSGVRTTSAEFYFTN--IILREKASIDDGIGYPSWSLALALAVAWIVIAGIMFKGVKSSGKASYF 280
            .....||.|..||..  :.|.:...||| :|.|.|.|...|.:..:::...::||||:|||..:.
Human   205 NDTFGTTPAAEYFERGVLHLHQSHGIDD-LGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWI 268

  Fly   281 LALFPYVVMLVLLVRALTLPGAFDGVLYFLRPQWHKLLEPQVWYAAVTQVFFSLAICFGNIIMYA 345
            .|..||||:..||:|.:|||||.||:..:|...:::|.|..||..|.|||.|||.:.||.:|.::
Human   269 TATMPYVVLTALLLRGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFS 333

  Fly   346 SYNRFGHNIYRDANIVTTLDTFTSLLSGVIIFGILGNLAYENNTTDIASVVNGGPGLAFISYPDA 410
            |||:|.:|.||||.:.|::::.||..||.::|..||.:| :.::..|..|...||||.||.||:|
Human   334 SYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMA-QKHSVPIGDVAKDGPGLIFIIYPEA 397

  Fly   411 IAKFKWLPQLFSVLFFLMLFVLGIGSNVGMASCMSTVIKDQF----GHLKNWTVVVGIAIVGYFL 471
            ||... |...::|:||:||..|||.|.:|....:.|.:.|:|    .|.:.:|:.:.:|.  :.|
Human   398 IATLP-LSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLAT--FLL 459

  Fly   472 GLLYITPGGQFLLNLVDYFGVTFVALVLAIFELVTIAWIYGVKRLCRDVEFMIGIKTSLYYRICW 536
            .|..:|.||.::..|:|:|......|...:.|.:.:||.|||.:...|::.|.|.:.|||:|:||
Human   460 SLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCW 524

  Fly   537 AVVTPLLMLTILIYTLVLYEPLKYKDYTYQSGVYVFGWCLSAFGVGQVLFWA 588
            .:|:|..:|.:::.::|.:.|..|..|.:.......||.::...:..|..:|
Human   525 KLVSPCFLLFVVVVSIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYA 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1698	NP_001260835.1	SLC6sbd	75..552	CDD:271359	181/483 (37%)
SLC6A3	NP_001035.1	SLC6sbd_DAT1	60..614	CDD:212083	190/522 (36%)
SLC6A3	NP_001035.1	Interaction with TGFB1I1. /evidence=ECO:0000269\|PubMed:12177201	561..590		4/16 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820