Protein Alignment CG1698 and SLC6A1

DIOPT Version :9

• Sequence 1: NP_001260835.1
• Gene: CG1698 / 36006
• FlyBaseID: FBgn0033443
• Length: 654
• Species: Drosophila melanogaster
• Sequence 2: NP_001335179.1
• Gene: SLC6A1 / 6529
• HGNCID: 11042
• Length: 599
• Species: Homo sapiens
• Alignment Length: 615
• Identity: 206/615 - (33%)
• Similarity: 336/615 - (54%)
• Gaps: 60/615 - (9%)

  Fly    39 SSNGKKTLSEGSGS---APPPGHGDSPSGVEAGQPGK-----KRDSWNNDIEFLMSCIALSVGLG 95
            ::||.| :::|..|   :..|...|.|..:......|     .||:|....:|||||:..::|||
Human     2 ATNGSK-VADGQISTEVSEAPVANDKPKTLVVKVQKKAADLPDRDTWKGRFDFLMSCVGYAIGLG 65

  Fly    96 NVWRFPFTALENGGGAFVIPYLIVLILVGKPVYYLEMLLGQFSSRGSVKVYDFSPIMRGIGYGQV 160
            ||||||:...:||||||:|||.:.||..|.|::.||..|||::|.|.:.|:..:|:.:|:|....
Human    66 NVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAA 130

  Fly   161 LATGIVTTYYATLMALTLRYFVDSFYPTLPWSYCREEWGTE-CLDSGPQEASRATSLAGSGVRTT 224
            :.:..:..||..:::..:.|..:||..||||..|...|.|: |..:            .|.|.||
Human   131 VLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSN------------YSMVNTT 183

  Fly   225 S-----AEFYFTNIILREKASIDDGIGYPS---WSLALALAVAWIVIAGIMFKGVKSSGKASYFL 281
            :     .||:..|:     ..:.||:..|.   |.||:.||:|||::...::|||..:||..||.
Human   184 NMTSAVVEFWERNM-----HQMTDGLDKPGQIRWPLAITLAIAWILVYFCIWKGVGWTGKVVYFS 243

  Fly   282 ALFPYVVMLVLLVRALTLPGAFDGVLYFLRPQWHKLLEPQVWYAAVTQVFFSLAICFGNIIMYAS 346
            |.:||:::::|..|.:|||||.:|:|:::.|.:.||.:.:||..|.||:|||..:..|::|...|
Human   244 ATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGS 308

  Fly   347 YNRFGHNIYRDANIVTTLDTFTSLLSGVIIFGILGNLAYENNTTDIASVVNGGPGLAFISYPDAI 411
            ||.|.:|:|||:.||..:::.||:.:|.:||.|:|.:|:....: ||.|...||||||::||:|:
Human   309 YNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRS-IADVAASGPGLAFLAYPEAV 372

  Fly   412 AKFKWLPQLFSVLFFLMLFVLGIGSNVGMASCMSTVIKDQFGHL---KNWTVVVGIAIVGYFLGL 473
            .:....| |:::|||.||.:|||.|.........|.:.|::..|   :....:..:.|:.|.:||
Human   373 TQLPISP-LWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIISYLIGL 436

  Fly   474 LYITPGGQFLLNLVDYFGVTFVALV-LAIFELVTIAWIYGVKRLCRDVEFMIGIKTSLYYRICWA 537
            ..||.||.::..|.||:..:.::|: |..||.|:|:|.|||.|...:::.|:|.:..:::::||:
Human   437 SNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWS 501

  Fly   538 VVTPLLMLTILIYTLVLYEPLKYKDYTYQSGVYVFGW--CLSAF----GVGQVLFWAIPAVRKQP 596
            ..||:::..:.|::.|...||...:|.:.......||  .||:.    |....:|..:....||
Human   502 FFTPIIVAGVFIFSAVQMTPLTMGNYVFPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKGSLKQ- 565

  Fly   597 SHLGLWARIRKAFEP-----LPNWGPSDPQ 621
                   ||:...:|     .|..||..||
Human   566 -------RIQVMVQPSEDIVRPENGPEQPQ 588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1698	NP_001260835.1	SLC6sbd	75..552	CDD:271359	176/489 (36%)
SLC6A1	NP_001335179.1	SLC6sbd_GAT1	2..599	CDD:212075	206/615 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599		5/12 (42%)
		PDZ-binding	597..599

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820