DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1698 and Slc6a17

DIOPT Version :9

Sequence 1:	NP_001260835.1	Gene:	CG1698 / 36006	FlyBaseID:	FBgn0033443	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_001028251.1	Gene:	Slc6a17 / 613226	RGDID:	1587185	Length:	727	Species:	Rattus norvegicus

Alignment Length:	596	Identity:	187/596 - (31%)
Similarity:	302/596 - (50%)	Gaps:	102/596 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 AGQPGKK------------RDSWNNDIEFLMSCIALSVGLGNVWRFPFTALENGGGAFVIPYLIV 119
            ||:.|.|            |.:||:.::::::.|..||||||:||||:...:|||||:::|||::
  Rat    41 AGETGGKQKVAEEELDAEDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVL 105

  Fly   120 LILVGKPVYYLEMLLGQFSSRGSVKVYDF-SPIMRGIGYGQVLATGIVTTYYATLMALTLRYFVD 183
            ||::|.|:::||:.:||...|||:.|:.: .|.:.|||:...:....|..||..::..::.||..
  Rat   106 LIIIGIPLFFLELAVGQRIRRGSIGVWHYVCPRLGGIGFSSCIVCLFVGLYYNVIIGWSVFYFFK 170

  Fly   184 SFYPTLPWSYCREEWGTECLDSGPQEASRATSLAGSGVRTTSAEFYFTNIILREKASIDDGI--- 245
            ||...||||.|            |...:...::.......:||..||.   .||...|.:.|
  Rat   171 SFQYPLPWSEC------------PVIRNGTVAVVEPECEKSSATTYFW---YREALDISNSISES 220

  Fly   246 GYPSWSLALALAVAWIVIAGIMFKGVKSSGKASYFLALFPYVVMLVLLVRALTLPGAFDGVLYFL 310
            |..:|.:.:.|.|||.::...:.||::||||..||.:||||||:...|||.|.|.||.||:|:..
  Rat   221 GGLNWKMTVCLLVAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGILHMF 285

  Fly   311 RPQWHKLLEPQVWYAAVTQVFFSLAICFGNIIMYASYNRFGHNIYRDANIVTTLDTFTSLLSGVI 375
            .|:..|:|:||||..|.|||||:|.:.||.:|.::|||:..:|.:.||.:|:.::.|||:|:.::
  Rat   286 TPKLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVLATLV 350

  Fly   376 IFGILG-----------------NLAYENN------------------TTDIASVVN-------- 397
            :|.:||                 .|.|.|:                  |.|.:.:.|
  Rat   351 VFAVLGFKANIMNEKCVVENAEKILGYLNSNVLSRDLIPPHVNFSHLTTKDYSEMYNVIMTVKEK 415

  Fly   398 --------------------GGPGLAFISYPDAIAKFKWLPQLFSVLFFLMLFVLGIGSNVGMAS 442
                                .|.|||||::.:|:..|...| .:||:|||||..||:||.:|..:
  Rat   416 QFSALGLDPCLLEDELDKSVQGTGLAFIAFTEAMTHFPASP-FWSVMFFLMLINLGLGSMIGTMA 479

  Fly   443 CMSTVIKDQFGHLKNWTVVVGIAIVGYFLGLLYITPGGQFLLNLVDYFGVTFVALVLAIFELVTI 507
            .::|.|.|.|...|. ...||..:..:|:|||::...|.:.:.:.|.:..|....|:.|.|.:.:
  Rat   480 GITTPIIDTFKVPKE-MFTVGCCVFAFFVGLLFVQRSGNYFVTMFDDYSATLPLTVIVILENIAV 543

  Fly   508 AWIYGVKRLCRDVEFMIGIKTSLYYRICWAVVTPLLMLTILIYTLVL--YEPLKY----KDYTYQ 566
            |||||.|:..:::..|:|.:...:|...|..|:||.|..:...:::.  ..|..|    |:...:
  Rat   544 AWIYGTKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGVSPPGYSAWIKEEAAE 608

  Fly   567 SGVYVFGWCLS 577
            ..:|...|.::
  Rat   609 RYLYFPNWAMA 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1698	NP_001260835.1	SLC6sbd	75..552	CDD:271359	177/543 (33%)
Slc6a17	NP_001028251.1	SLC6sbd_NTT4	60..648	CDD:271403	183/577 (32%)
Slc6a17	NP_001028251.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	680..727
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820