DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1698 and slc6a6b

DIOPT Version :9

Sequence 1:	NP_001260835.1	Gene:	CG1698 / 36006	FlyBaseID:	FBgn0033443	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_001032750.1	Gene:	slc6a6b / 569098	ZFINID:	ZDB-GENE-030131-3077	Length:	625	Species:	Danio rerio

Alignment Length:	599	Identity:	220/599 - (36%)
Similarity:	322/599 - (53%)	Gaps:	32/599 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 KKTLSEGSGSAPPPGHGDSPSGVEAGQPGKKRDSWNNDIEFLMSCIALSVGLGNVWRFPFTALEN 107
            |..|....|.:|    |..|.. ||.....:|:.|.:.::||:|.....||||||||||:...:|
Zfish    15 KDILKPSPGKSP----GTRPED-EAEGKHPQREKWASKLDFLLSVAGGFVGLGNVWRFPYLCYKN 74

  Fly   108 GGGAFVIPYLIVLILVGKPVYYLEMLLGQFSSRGSVKVYD-FSPIMRGIGYGQVLATGIVTTYYA 171
            |||||:|||.|.|...|.||::||:.||||:|.|.:..:: ..||..||||..::...::..||.
Zfish    75 GGGAFLIPYFIFLFGGGLPVFFLEVALGQFTSEGGITCWEKLCPIFTGIGYASIVIVSLLNIYYI 139

  Fly   172 TLMALTLRYFVDSFYPTLPWSYCREEWGTECLDSGPQEASRATSLAGSGVRTTS--AEFYFTNII 234
            .::|..|.|....|.|.|||:.|..:|.||.........::....|.:....||  .||:..|::
Zfish   140 VILAWGLYYLFQCFQPELPWASCNNKWNTENCVEDTLRRNKTLWAAANATNFTSPVTEFWERNVL 204

  Fly   235 LREKASIDDGI---GYPSWSLALALAVAWIVIAGIMFKGVKSSGKASYFLALFPYVVMLVLLVRA 296
                 ||.|||   |:..|.|||.|...|::....::|||||:||..|..|.||:|:::|||||.
Zfish   205 -----SISDGIEEVGHVKWDLALCLLAMWVICFFCVWKGVKSTGKVVYVTATFPFVMLIVLLVRG 264

  Fly   297 LTLPGAFDGVLYFLRPQWHKLLEPQVWYAAVTQVFFSLAICFGNIIMYASYNRFGHNIYRDANIV 361
            :|||||.:|:.::|.|...:|.:|:||..|.||:|||.|||.|.:....|||::.:|.|||..::
Zfish   265 VTLPGAAEGIKFYLYPNVTRLGDPEVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNCYRDCLLL 329

  Fly   362 TTLDTFTSLLSGVIIFGILGNLAYENNTTDIASVVNGGPGLAFISYPDAIAKFKWLPQLFSVLFF 426
            ..|::.||.:||..||.:||.:|.|.. .|||.|...|||||||:||.|:.... ||..:::|||
Zfish   330 GGLNSATSFVSGFAIFSVLGFMAQEQG-VDIADVAESGPGLAFIAYPKAVTMMP-LPTFWAILFF 392

  Fly   427 LMLFVLGIGSNVGMASCMSTVIKDQF------GHLKNWTVVVGIAIVGYFLGLLYITPGGQFLLN 485
            :||.:||:.|.........|.:.|.:      |:.:...:.: :..|.|.|||..:|.||.::..
Zfish   393 IMLLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAI-VCFVSYLLGLTMVTEGGMYVFQ 456

  Fly   486 LVDYFGVTFVALV-LAIFELVTIAWIYGVKRLCRDVEFMIGIKTSLYYRICWAVVTPLLMLTILI 549
            |.||:..:.|.|: :|.||.:.:||:||.......:|.|||.:.:.:.:..|.||||.|.:...|
Zfish   457 LFDYYAASGVCLLWVAFFECIAVAWVYGADNFYDAIEEMIGYRPNPWMKWSWTVVTPFLCVGCFI 521

  Fly   550 YTLVLYEPLKY-KDYTYQSGVYVFGWCLSAFGVGQVLFWAIPAVRKQPSHLGLWARIRKAFEPLP 613
            ::||.|.||:| |.|.|.......||.|:.  ...:....:..::...|...|..||:....|:.
Zfish   522 FSLVKYAPLRYNKIYEYPDWSIGVGWTLAL--ASMICIPMVVVIKIIQSDGPLIERIKAVAAPVR 584

  Fly   614 NWGPSDPQTLKRYQ 627
            ....|.||   .||
Zfish   585 GGASSCPQ---EYQ 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1698	NP_001260835.1	SLC6sbd	75..552	CDD:271359	189/489 (39%)
slc6a6b	NP_001032750.1	SLC6sbd_TauT	41..582	CDD:271398	206/550 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920