DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1698 and slc6a8

DIOPT Version :9

Sequence 1:	NP_001260835.1	Gene:	CG1698 / 36006	FlyBaseID:	FBgn0033443	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_001314797.1	Gene:	slc6a8 / 567544	ZFINID:	ZDB-GENE-071024-2	Length:	652	Species:	Danio rerio

Alignment Length:	613	Identity:	224/613 - (36%)
Similarity:	346/613 - (56%)	Gaps:	54/613 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 PN----ESSNGKKTLSEGSGSAPPPGHGDSPSGVEAGQPG-KKRDSWNNDIEFLMSCIALSVGLG 95
            ||    .|.||  ||:.|..||..    .:.|.||..:.| .:|::|...::|:|||:..:||||
Zfish    27 PNGNAHPSVNG--TLNGGPMSAAT----GAISAVEKKREGYPERETWTRQMDFIMSCVGFAVGLG 85

  Fly    96 NVWRFPFTALENGGGAFVIPYLIVLILVGKPVYYLEMLLGQFSSRGSVKVYDFSPIMRGIGYGQV 160
            ||||||:...:||||.|:|||::.:.|.|.|:::||:.||||...||:.|::.:|:.:|:||..:
Zfish    86 NVWRFPYLCYKNGGGVFLIPYVLFIFLGGIPIFFLEIALGQFMKAGSINVWNIAPLFKGLGYASM 150

  Fly   161 LATGIVTTYYATLMALTLRYFVDSFYPTLPWSYCREEWGTE-CLDSGPQEASRATSLAGS----- 219
            :......|||..::|....||:.||..|||||.|...|.|| |::...|...:..::..|
Zfish   151 VIVFFCNTYYIMVLAWGFYYFIKSFNATLPWSTCDNPWNTENCIEIFRQGDCKNGTIGNSTFGNL 215

  Fly   220 ------GVRTTSAEFYFTNIILREKASIDDGIGYP---SWSLALALAVAWIVIAGIMFKGVKSSG 275
                  ..|:...||:...::     :|.||:..|   :|.|.|.|...|:::...::|||||:|
Zfish   216 TCEELANGRSPIIEFWENKVL-----NISDGLDEPGAVNWELMLCLLAVWVMVYFCVWKGVKSTG 275

  Fly   276 KASYFLALFPYVVMLVLLVRALTLPGAFDGVLYFLRPQWHKLLEPQVWYAAVTQVFFSLAICFGN 340
            |..||.|.|||||:::||||.:|||||:||:||:::|.|.||.|.|||..|.||:|||.||..|.
Zfish   276 KIVYFTATFPYVVLIILLVRGVTLPGAYDGILYYVKPDWSKLGEAQVWIDAGTQIFFSYAIGLGA 340

  Fly   341 IIMYASYNRFGHNIYRDANIVTTLDTFTSLLSGVIIFGILGNLAYENNTTDIASVVNGGPGLAFI 405
            :....|||||.::.|:||.::..:::.||..:|.::|.|||.:|.|.. .||:.|...|||||||
Zfish   341 LTALGSYNRFNNDCYKDAFVLALINSGTSFFAGFVVFSILGFMASEQG-VDISKVAESGPGLAFI 404

  Fly   406 SYPDAIAKFKWLPQLFSVLFFLMLFVLGIGSN-VGMASCMSTVIKDQF--GHLKNWTVVVGIAI- 466
            :||.|::.....| :::.|||:||.:||:.|. ||:...: |.|.|.|  .:...:...:.:||
Zfish   405 AYPKAVSMMPVAP-VWAALFFIMLLLLGLDSQFVGVEGFV-TGILDLFPGKYYMRYQREIAVAIC 467

  Fly   467 --VGYFLGLLYITPGGQFLLNLVDYFGVTFVALV-LAIFELVTIAWIYGVKRLCRDVEFMIGIKT 528
              :.:.:.|..:|.||.::..|.||:..:.:.|: .|.:|.|.:||:||..|...|:..|||.:.
Zfish   468 CLLCFIIDLSMVTQGGMYVFQLFDYYSASGMTLLWQAFWECVVVAWVYGADRFMDDIARMIGYRP 532

  Fly   529 SLYYRICWAVVTPLLMLTILIYTLVLYEPLKYKD-YTYQSGVYVFGWCLSAFGVGQVLFWAIPAV 592
            ..:.:.||:::||.:.:.|.::.|:.|:||.|.: |.|.....|.||||:   :..:|...:..|
Zfish   533 FPWMKWCWSIITPCVCMGIFLFHLLNYKPLTYNNVYVYPWWGEVIGWCLA---LSSMLCIPVSLV 594

  Fly   593 RKQPSHLGL----WARIRKAFEPLPNWG 616
            .|.....|.    |..:.|     |.||
Zfish   595 YKLSGAKGTFKERWENLTK-----PVWG 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1698	NP_001260835.1	SLC6sbd	75..552	CDD:271359	188/498 (38%)
slc6a8	NP_001314797.1	SLC6sbd_CT1	64..652	CDD:271397	210/570 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820