DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1698 and slc6a2

DIOPT Version :9

Sequence 1:	NP_001260835.1	Gene:	CG1698 / 36006	FlyBaseID:	FBgn0033443	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	XP_009301625.1	Gene:	slc6a2 / 565776	ZFINID:	ZDB-GENE-110408-4	Length:	625	Species:	Danio rerio

Alignment Length:	572	Identity:	207/572 - (36%)
Similarity:	321/572 - (56%)	Gaps:	26/572 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 ESSNGKKTLSEGSGSAPPPGHGDSPSGVEAGQPGKKRDSWNNDIEFLMSCIALSVGLGNVWRFPF 102
            :..||.:..:....::|......|.||.|.     :|::|...::||:|.|..:|.|.||||||:
Zfish    33 KEQNGVQYTNSSVVASPSSRACTSASGEEI-----ERETWGKKMDFLLSVIGFAVDLANVWRFPY 92

  Fly   103 TALENGGGAFVIPYLIVLILVGKPVYYLEMLLGQFSSRGSVKVYDFSPIMRGIGYGQVLATGIVT 167
            ...:||||||:|||::.|.:.|.|::|:|:.|||::..|:..::...|:.:|:||..::....|.
Zfish    93 LCYKNGGGAFLIPYVLFLFIAGMPLFYMELALGQYNREGAATLWKICPVFKGVGYTVIVIALYVG 157

  Fly   168 TYYATLMALTLRYFVDSFYPTLPWSYCREEWGT-ECLDSGPQEASRATSLAGSGV------RTTS 225
            .||..::|.:|.|...|....|||.:|...|.: .|.:  |::.:  .::.|:|.      .|.:
Zfish   158 FYYNVIIAWSLYYLYASLTSELPWLHCNNPWNSPNCTE--PKDIN--GTVLGNGTSYAKYKNTPA 218

  Fly   226 AEFYFTNII-LREKASIDDGIGYPSWSLALALAVAWIVIAGIMFKGVKSSGKASYFLALFPYVVM 289
            ||||...:: ..|...|.| :|.|.|.|.:.|.|...::...::||||||||..|..|..||:|:
Zfish   219 AEFYERGVLHSHESKGIGD-LGLPRWELTICLVVVAFILYFSLWKGVKSSGKVVYITATMPYIVL 282

  Fly   290 LVLLVRALTLPGAFDGVLYFLRPQWHKLLEPQVWYAAVTQVFFSLAICFGNIIMYASYNRFGHNI 354
            ||||:|.:|||||.:|:..:|.....||..||||..|.||:||||...||.:|.::|||:|.:|.
Zfish   283 LVLLIRGITLPGAMNGIRAYLHIDLKKLNNPQVWIDAATQIFFSLGAGFGVLIAFSSYNKFNNNC 347

  Fly   355 YRDANIVTTLDTFTSLLSGVIIFGILGNLAYENNTTDIASVVNGGPGLAFISYPDAIAKFKWLP- 418
            ||||.:.:|::..||..||..||.:||.:| |.:..:|..|...|.||.|:.||:||:.   ||
Zfish   348 YRDAILTSTINCVTSFFSGFAIFSVLGYMA-EQHKVNIKDVATEGAGLVFVIYPEAIST---LPG 408

  Fly   419 -QLFSVLFFLMLFVLGIGSNVGMASCMSTVIKDQFGHLK-NWTVVVGIAIVGYFL-GLLYITPGG 480
             ..|:::||:||..|||.|::|....:.|.:.|.|..|| |..:.....:||.|| .||.:|.||
Zfish   409 ATFFAIVFFIMLLTLGIDSSMGGMEAVLTGLSDDFKILKRNRKLFTFATVVGTFLMALLCVTNGG 473

  Fly   481 QFLLNLVDYFGVTFVALVLAIFELVTIAWIYGVKRLCRDVEFMIGIKTSLYYRICWAVVTPLLML 545
            .::|.|:|.:......|...:||.:.::|.|||.|...|:|.|:|.|..:|:|:||..|:|..:|
Zfish   474 IYVLTLLDKYAAGTSILFGVLFEAIGVSWFYGVDRFSEDIERMMGFKPGIYWRLCWKFVSPAFLL 538

  Fly   546 TILIYTLVLYEPLKYKDYTYQSGVYVFGWCLSAFGVGQVLFWAIPAVRKQPS 597
            .::|.::|....|.|.:|.:.....:.||.::...:..|.|:||......||
Zfish   539 LVVIASIVTSGRLTYDEYVFPYWADMLGWSIALSSMLFVPFYAIYKFFSVPS 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1698	NP_001260835.1	SLC6sbd	75..552	CDD:271359	187/488 (38%)
slc6a2	XP_009301625.1	SLC5-6-like_sbd	64..623	CDD:294310	200/536 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920