DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1698 and slc6a7

DIOPT Version :9

Sequence 1:	NP_001260835.1	Gene:	CG1698 / 36006	FlyBaseID:	FBgn0033443	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	XP_005161359.1	Gene:	slc6a7 / 562050	ZFINID:	ZDB-GENE-070112-1492	Length:	652	Species:	Danio rerio

Alignment Length:	608	Identity:	224/608 - (36%)
Similarity:	330/608 - (54%)	Gaps:	51/608 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 ISIPGAYKPNESSNGKKTLSEGSGSAPPPGHGDSPSGVEAGQPGKKRDSWNNDIEFLMSCIALSV 92
            |:.|....| ...||..:....|.|.||......|:     ||  .||.|....|||:|||...|
Zfish    33 ITTPSTENP-AHQNGAVSSPVASQSQPPSSAASPPA-----QP--PRDQWGGKYEFLLSCIGYCV 89

  Fly    93 GLGNVWRFPFTALENGGGAFVIPYLIVLILVGKPVYYLEMLLGQFSSRGSVKVYDFSPIMRGIGY 157
            |||||||||:....||||.|:|||.|:|...|.|::.:|:.|||:.:.|.:.|:...|:::|||.
Zfish    90 GLGNVWRFPYLCYRNGGGVFLIPYFIMLFFTGMPLFLMELSLGQYGAAGPITVWKCCPLLKGIGI 154

  Fly   158 GQVLATGIVTTYYATLMALTLRYFVDSFYPTLPWSYCREEWGTECLDSGPQEASRATSLAGSGVR 222
            |.:..:.:|..||..::|.|..|...||...||||         |      :|.:..:|..:...
Zfish   155 GMLCVSTLVCLYYNVIIAWTFYYLGSSFQSPLPWS---------C------DALQNIALCANKTN 204

  Fly   223 TTS--AEFYFTNIILREKASIDDGIGYPS---WSLALALAVAWIVIAGIMFKGVKSSGKASYFLA 282
            :|.  :|.::...:|....|  .|:..|.   |.|||.|..|||:|...|.||:.||||..|..|
Zfish   205 STQSPSEVFWNEKVLGVVHS--TGLSDPGPVRWPLALCLLAAWIIIFLCMLKGIHSSGKVVYVTA 267

  Fly   283 LFPYVVMLVLLVRALTLPGAFDGVLYFLRPQWHKLLEPQVWYAAVTQVFFSLAICFGNIIMYASY 347
            .|||.|:|||::|..||.|:.|||.::|.|:|.:|.:.|||..|.:|:|:||.|..|.::..|||
Zfish   268 TFPYFVLLVLIIRGATLEGSLDGVAFYLTPKWDQLADAQVWNDAASQIFYSLGIGVGGLLSMASY 332

  Fly   348 NRFGHNIYRDANIVTTLDTFTSLLSGVIIFGILGNLAYENNTTDIASVVNGGPGLAFISYPDAIA 412
            |:|.:|:.||..|:|..:..||..:|..||.|||::|::.. ..:..|.:.||||||::||:|:|
Zfish   333 NKFDNNVIRDTIIITIGNCSTSFFAGFAIFSILGHMAFKKG-VPVDKVADSGPGLAFVAYPEALA 396

  Fly   413 KFKWLP--QLFSVLFFLMLFVLGIGSNVGMASCMSTVIKDQF----GHLKNWTVVVGIAIVGYFL 471
               .||  ..:|:|||||||:||:.:..|....:.|.:.|:|    .:||:.|:.:.:....::|
Zfish   397 ---LLPGSVFWSILFFLMLFMLGVDTLFGNMEGICTAVLDEFPQLRSNLKHKTLFLAVLCFSFYL 458

  Fly   472 -GLLYITPGGQFLLNLVDYFGVTFVALVLAIFELVTIAWIYGVKRLCRDVEFMI------GIKTS 529
             |||.||.||.:...|:|.|..:|..:::.:|..:.|::.|||.:.|:|:..||      ..|..
Zfish   459 MGLLLITDGGIYWFTLIDSFSTSFGLIIITLFMCIGISFFYGVNQFCQDIVDMICRCPPWCTKML 523

  Fly   530 LYYRICWAVVTPLLMLTILIYTLV-LYE-PLKYKDYTYQSGVYVFGWCLSAFGVGQVLFWAIPAV 592
            ||::.||.|.||.|:..||.|..: :|. .|:|..|.|.......|.|:.|....|:|.|||.|:
Zfish   524 LYFKACWVVFTPFLLTFILTYIFIEMYRTSLRYGSYVYPIWGKALGVCMGALCCLQILIWAIVAI 588

  Fly   593 RKQPSHLGLWARIRKAFEPLPNW 615
            .|:...|.  .|.:|:..||.:|
Zfish   589 SKESGTLK--DRFKKSIRPLNSW 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1698	NP_001260835.1	SLC6sbd	75..552	CDD:271359	190/494 (38%)
slc6a7	XP_005161359.1	SLC5-6-like_sbd	71..610	CDD:294310	212/562 (38%)
slc6a7	XP_005161359.1	PotE	<235..564	CDD:223605	133/332 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920