DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1698 and slc6a22.2

DIOPT Version :9

Sequence 1:	NP_001260835.1	Gene:	CG1698 / 36006	FlyBaseID:	FBgn0033443	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	XP_005166102.1	Gene:	slc6a22.2 / 561024	ZFINID:	ZDB-GENE-030616-628	Length:	608	Species:	Danio rerio

Alignment Length:	612	Identity:	218/612 - (35%)
Similarity:	326/612 - (53%)	Gaps:	54/612 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 VEAGQPGKKRDSWNNDIEFLMSCIALSVGLGNVWRFPFTALENGGGAFVIPYLIVLILVGKPVYY 129
            |:|......|:.|.|.:|||::.....:|||||||||:...:||||||.:||::.|...|.|:::
Zfish    19 VKARPKPPAREQWANKLEFLLAVAGHIIGLGNVWRFPYLCYKNGGGAFFVPYVLFLFTCGIPLFF 83

  Fly   130 LEMLLGQFSSRGSVKVY-DFSPIMRGIGYGQ---VLATGIVTTYYATLMALTLRYFVDSFYPTLP 190
            ||..||||:|:|.:..: ...|:..|:|:|.   ||.||:   ||..::|....|...||...||
Zfish    84 LETSLGQFTSQGGITCWRKICPLFEGLGFGSQVVVLYTGV---YYIIILAWAFLYLFSSFTSELP 145

  Fly   191 WSYCREEWGT-ECLDSGPQEASRATSLAGSGVRTTS--AEFYFTNIILREKASIDDG---IGYPS 249
            |:.|...|.| .|:     |.|.:.....|..:|||  .||:...|:     .:..|   ||...
Zfish   146 WASCNNYWNTPSCM-----EFSESNITEYSPNKTTSPVIEFWERRIL-----GLSGGIEQIGNVR 200

  Fly   250 WSLALALAVAWIVIAGIMFKGVKSSGKASYFLALFPYVVMLVLLVRALTLPGAFDGVLYFLRPQW 314
            |.|||.|.:|||:....::|||||:||..||.|.|||::::|||||.||||||.:|:.::|.|..
Zfish   201 WDLALCLLLAWIICYFCVWKGVKSTGKVVYFTATFPYLMLIVLLVRGLTLPGAINGITFYLYPDP 265

  Fly   315 HKLLEPQVWYAAVTQVFFSLAICFGNIIMYASYNRFGHNIYRDANIVTTLDTFTSLLSGVIIFGI 379
            .:|.:||||..|.:|:|:|..:|.|.:....|||::.:|.|||...:..|::.||.::|..||.:
Zfish   266 SRLKDPQVWMDAGSQIFYSYGVCTGVLTALGSYNKYDNNCYRDCVYLCLLNSLTSFVAGFAIFSV 330

  Fly   380 LGNLAYENNTTDIASVVNGGPGLAFISYPDAIAKFKWLPQLFSVLFFLMLFVLGIGSNVGMASCM 444
            ||.:|.|.. .||:.|...|||||||:||.|:|... ||||:::.||:|:..||:.|.......:
Zfish   331 LGFMADEQG-VDISLVAESGPGLAFIAYPRAVALMP-LPQLWAIFFFIMIIFLGLDSEFVYQEAL 393

  Fly   445 STVIKD------QFGHLKNWTVVVGIAIVGYFLGLLYITPGGQFLLNLVDYF---GVTFVALVLA 500
            .|.|.|      |.||.:.: :::.|....:|:|||.:|.||.::..|.||:   |:|.  |..|
Zfish   394 VTSISDMYPSFFQVGHRRKF-LLLFICSASFFVGLLMVTEGGLYVFQLFDYYACSGMTL--LTFA 455

  Fly   501 IFELVTIAWIYGVKRLCRDVEFMIGIKTSLYYRICWAVVTPLLMLTILIYTLVLYEPLKY-KDYT 564
            |.:.:.:.|:||..|....||.|||.:...:.:.||..:||.:.....|::||.|.|||: .:|.
Zfish   456 ILQSICVGWVYGADRHYDCVEDMIGYRPWPFMKCCWKYLTPAICTGTFIFSLVQYTPLKFNNEYE 520

  Fly   565 YQSGVYVFGWCLSAFGVGQVLFWAIPAVRKQPSHLGLWARIRKAFEP---LPNWGPSDPQTLKR- 625
            |....|..|...:......|..|.|..|...|.  .:..|:|....|   ||     ||:..|:
Zfish   521 YPWWGYAIGGFFTLSSTLLVPLWMIYLVGTTPG--SMRQRVRALCTPAEDLP-----DPKCPKQK 578

  Fly   626 -----YQLFVQEGNANALFRRSSIWHK 647
                 ::.|........:..::|:.|:
Zfish   579 LNTATFETFTDLLTLRTVHIQNSLPHR 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1698	NP_001260835.1	SLC6sbd	75..552	CDD:271359	189/495 (38%)
slc6a22.2	XP_005166102.1	SLC6sbd-TauT-like	28..565	CDD:271387	207/556 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820