DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1698 and slc6a6a

DIOPT Version :9

Sequence 1:	NP_001260835.1	Gene:	CG1698 / 36006	FlyBaseID:	FBgn0033443	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_001119858.1	Gene:	slc6a6a / 556480	ZFINID:	ZDB-GENE-081104-1	Length:	625	Species:	Danio rerio

Alignment Length:	624	Identity:	220/624 - (35%)
Similarity:	335/624 - (53%)	Gaps:	45/624 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 KKTLSEGSGSAPPPGHGDSPSGVEAGQPGKKRDSWNNDIEFLMSCIALSVGLGNVWRFPFTALEN 107
            |.||....|.:|    |..|.. ||.....:|:.|.:.::|::|.....||||||||||:...:|
Zfish    15 KDTLKPSPGKSP----GTRPED-EAEGKAPQREKWASKLDFVLSVAGGFVGLGNVWRFPYLCYKN 74

  Fly   108 GGGAFVIPYLIVLILVGKPVYYLEMLLGQFSSRGSVKVY-DFSPIMRGIGYGQVLATGIVTTYYA 171
            |||||:|||.|.|...|.||::||:.||||:|.|.:..: ...||..||||..::...::..||.
Zfish    75 GGGAFLIPYFIFLFGGGLPVFFLEVALGQFTSEGGITCWGKLCPIFTGIGYASIIIVSLLNIYYI 139

  Fly   172 TLMALTLRYFVDSFYPTLPWSYCREEWGTE-CLDSGPQEASRATSLAGSGVRTTS--AEFYFTNI 233
            .::|..|.|.:..|...|||:.||..|.|| |::...:: ::...|:.:....||  .||:..|:
Zfish   140 VILAWGLYYLLQCFQHELPWARCRHSWNTENCVEDTVRK-NKTLWLSANATNFTSPVTEFWERNV 203

  Fly   234 ILREKASIDDGI---GYPSWSLALALAVAWIVIAGIMFKGVKSSGKASYFLALFPYVVMLVLLVR 295
            :     ||..||   |...|.|||.|...|::....::|||||:||..||.|.||:::::|||:|
Zfish   204 L-----SISSGIDEVGGLKWELALCLLAVWVICFFCIWKGVKSTGKVVYFTATFPFLMLIVLLIR 263

  Fly   296 ALTLPGAFDGVLYFLRPQWHKLLEPQVWYAAVTQVFFSLAICFGNIIMYASYNRFGHNIYRDANI 360
            .:|||||.:|:.::|.|...:|.:|:||..|.||:|||.|||.|.:....|||::.:|.|||..:
Zfish   264 GVTLPGATEGIKFYLYPDLSRLKDPEVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNCYRDCML 328

  Fly   361 VTTLDTFTSLLSGVIIFGILGNLAYENNTTDIASVVNGGPGLAFISYPDAIAKFKWLPQLFSVLF 425
            :..|::.||.:||..||.:||.:|.|.... ||.|...|||||||:||.|:.... ||.::::||
Zfish   329 LGCLNSGTSFVSGFAIFSVLGFMAQEQGIA-IADVAESGPGLAFIAYPKAVTMMP-LPTVWAILF 391

  Fly   426 FLMLFVLGIGSNVGMASCMSTVIKDQF------GHLKNWTVVVGIAIVGYFLGLLYITPGGQFLL 484
            |:||.:||:.|.........|.:.|.:      |:.:...:.| |.::.|.|||..:|.||.::.
Zfish   392 FIMLLLLGLDSQFVEVEGQITSLVDLYPSLLRKGYRREIFIAV-ICVISYLLGLTMVTKGGMYVF 455

  Fly   485 NLVDYFGVTFVALV-LAIFELVTIAWIYGVKRLCRDVEFMIGIKTSLYYRICWAVVTPLLMLTIL 548
            .|.||:..:.|.|: :|.||.|.:||:||.......:|.|||.:.:.:.:..|.::||:|.:...
Zfish   456 QLFDYYAASGVCLLWVAFFECVAVAWVYGADNFYDAIEDMIGYRPNSWMKWSWMLITPVLCVGCF 520

  Fly   549 IYTLVLYEPLKY-KDYTYQSGVYVFGWCLSAFGVGQVLFWAIPAVRKQPSHLGLWARIRKAFEPL 612
            :::||.|:||.| |.|.|.......||.|:.  ...:....:..::...|...|..||:....|:
Zfish   521 VFSLVKYKPLTYNKLYKYPDWSIGLGWALAL--ASMICIPMMVVIKIIQSDGSLIERIKAVAAPV 583

  Fly   613 PNWGPSDPQTLKRYQLFVQEGNANALFRRSSIWHKIYDN 651
            .....|.|   |.|.|           :.|.:.|.:..|
Zfish   584 KGGASSRP---KEYSL-----------KNSELLHPLDPN 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1698	NP_001260835.1	SLC6sbd	75..552	CDD:271359	185/490 (38%)
slc6a6a	NP_001119858.1	SLC6sbd_TauT	41..582	CDD:271398	202/551 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920